A. Kalsbeek

R.M. Buijs

H.J. Romijn

M. Mirmiran

C.M.A. Pennartz

The International Summer School of Brain Research, on which this book is based, was organized by the Netherlands Institute for Brain research (NIBR), which has a rich history dating back to the beginning of the century. The focus of interest in this present volume of Progress in Brain Research are the few thousand neurons at the base of the hypothalamus that form the biological clock. Attention is focused on the mechanisms underlying the generation of circadian rhythmicity within our biological clock, which is still far from understood. Contributions originating from many disciplines give updates on the latest theories on the molecular and electrophysiological basis of the pacemaker mechanism, and the various approaches used in different species. Attention is also paid to the way the signal of the biological clock is transferred to the rest of the central nervous system. New data on the role of the suprachiasmatic nucleus and its impact on the functioning of the human being is presented. Altogether an excellent volume which will further the understanding of this elusive material.

Hypothalamic Integration of Circadian Rhythms

Michel A. Hofman

Eric Fliers

D.F. Swaab

Eus JW Van Someren

The prevalence of obesity in developed countries is fast becoming a health issue on par with infectious diseases and malnutrition. Research in this area has grown substantially and includes the neurochemical pathways of the hypothalamus and its role in regulating energy expenditures in the body. This volume in the Progress in Brain Research series examines the emerging role of the hypothalamus as a crucial link between the sensing of nutrients and the control of insulin sensitivity, glucose uptake, and glucose production, the integrative role of the hypothalamus in thyroid and bone metabolism, the interaction between circadian information and energy metabolism, and the important interplay between the immune system and energy metabolism. · All contributors are recognized experts in their respective specialities · Provides expanded coverage of hypothalamic mechanisms involved in energy metabolism · Includes many outstanding full-colour illustrations · Contains special sections on circadian rhythms, immune system, thyroid and bone metabolism

Hypothalamic Integration of Energy Metabolism

A. Kalsbeek

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