Jesus Avila

Jose J. Lucas

Felix Hernandez

Ana Martinez

This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics.

Animal Models for Neurodegenerative Disease

Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.

Emerging Drugs and Targets for Multiple Sclerosis

David E. Thurston

David Rotella

Salvatore Guccione

Rob M. Jones

This book is a state-of-the art review of new therapeutic strategies towards treatments for T2D.

Small Molecule Approaches

New Therapeutic Strategies for Type 2 Diabetes

Olga Genilloud

Francisca Vicente

Robin Ganellin

An integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

Drug Discovery from Natural Products

Miguel Medina

Ana Castro

Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It’s a great reference for researchers in drug design and development.

Drug Discovery and Development

Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors

Ana Martinez

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