Artemis P. Simopoulos

John A. Milner

Awareness of the influence of our genetic variation to dietary response (nutrigenetics) and how nutrients may affect gene expression (nutrigenomics) is prompting a revolution in the field of nutrition. Nutrigenetics/Nutrigenomics provide powerful approaches to unravel the complex relationships among nutritional molecules, genetic variants and the biological system. This publication contains selected papers from the '3rd Congress of the International Society of Nutrigenetics/Nutrigenomics' held in Bethesda, Md., in October 2009. The contributions address frontiers in nutrigenetics, nutrigenomics, epigenetics, transcriptomics as well as non-coding RNAs and posttranslational gene regulations in various diseases and conditions. In addition to scientific studies, the challenges and opportunities facing governments, academia and the industry are included. Everyone interested in the future of personalized medicine and nutrition or agriculture, as well as researchers in academia, government and industry will find this publication of the utmost interest for their work.

Translating Nutrigenetic/nutrigenomic Research Into Dietary Guidelines

Personalized Nutrition

This is the first of two volumes recording the proceedings of the 3rd International Conference on Nutrition and Fitness. It is the first publication to provide the latest research on the role of exercise and nutrients in gene expression; define the relationship that exists among exercise, nutrition, health and fitness, and examine the scientific evidence from an evolutionary perspective. Stimulating and well-organized, this volume will interest geneticists, anthropologists, exercise physiologists, nutritionists and dietitians, psychologists and psychiatrists, pediatricians, internists, general practitioners, health care providers, industrial scientists, policymakers, and national and international governmental organizations.

Evolutionary Aspects, Children's Health, Programs, and Policies : 3rd International Conference on Nutrition and Fitness, Athens, May 24-27, 1996

Nutrition and Fitness

The Healthiest Diet for You: Scientific Aspects is unique in a sense because it focuses on the most recent advances in Nutrition, Metabolism, and Genetics that are the basic components of Personalized Nutrition. The book also emphasizes the importance of evolutionary aspects of diet and exercise and the need to select foods that are consistent with the evolutionary aspects of diet because these are the foods that contain the nutrients that our genes are programmed to respond. This book is the antidote to ultra-processed foods and imitation foods that are proinflammatory and contribute to increases in chronic diseases, especially cardiovascular disease. It is a book for Health! The aim of the book is to provide readers with the basic factual information necessary to comprehend the enormity and potential effects of nutrients and foods on overall health and well-being. This book should be of interest to the educated public, teachers, health professionals, physicians, medical students, nutritionists, dietitians, historians and policy makers.

Scientific Aspects

The Healthiest Diet for You

This unique publication for the first time brings together scientists from academia, government and industry to discuss the role of omega-3 fatty acids in health, the need to reintroduce them into the food supply, the methods by which this can be accomplished and the state of research. With the domestication of animals, there has been a change in animal feeds, which in turn transformed the composition of meats, particularly the content of essential fatty acids. Changes similar to those in meats have occurred in the composition of eggs, poultry and in fish from aquaculture. Up-to-date reviews on the role of omega-3 fatty acids in health, cardiovascular disease, bone remodeling relative to osteoporosis and in patients with retinitis pigmentosa emphasize the need for a balance of omega-6 and omega-3 fatty acids in the food supply. The reintroduction of omega-3 fatty acids into food products is discussed, and the methods involved in their production as well as their metabolic effects on human beings and companion animals are outlined. Overall, the papers presented indicate the necessity to establish recommended daily intakes for both omega-6 and omega-3 fatty acids. Furthermore, there is a need to redefine food safety; changes in food composition must also be taken into consideration. This unique publication is a valuable source for physicians, nutritionists, dietitians, veterinarians and agriculturalists, as well as for all those concerned with aspects of food production, food technology, food policy and consumer issues.

Land-Based Animal Food Products and Their Health Effects

The Return of W3 Fatty Acids Into the Food Supply

Ramesh Venkataramana Bhat

This publication focuses on street foods in selected developed and developing countries, including information on nutritional, economic, safety and regulatory aspects and comparing consumption patterns as well as the profiles of the street food vendor in different cultures. Street foods are inexpensive and available foods that in many countries form an integral part of the diet because they are consumed with regularity and consistency across all income groups, but particularly among the urban poor and schoolchildren. The street food trade is large and complex, providing an important means of generating income, particularly for women, and it is an affordable source of food for many millions of people. Street foods have therefore been considered as a way of reducing problems of urban food insecurity and as a possible vehicle for micronutrient supplementation. Scientists and policy makers in the areas of international health, nutrition, food and trade as well as physicians, nutritionists, dietitians, food scientists, anthropologists, sociologists will particularly benefit from this publication.

Street Foods

Fabien De Meester

For more than half a century, the relationship between dietary factors and coronary heart disease (CHD) has been a major focus of health research. Contrary to the established view, current data suggest that dietary cholesterol is not a primary factor of or causes heart disease with the possible exception of the genetic forms of familial hypercholesterolemias. For instance, recent clinical trials evaluating the effect of cholesterol-lowering drugs on the development of chronic heart failure, diabetes and stroke have yielded disappointing results. On the other hand, an unbalanced omega-6/omega-3 fatty acid ratio and a cholesterol intake not consistent with the amount during evolution seem to be causal factors in the development of CHD. A panel of international experts in genetics, nutrition, fatty acid, cholesterol, metabolism and coronary heart disease has contributed to this publication, summarizing and critically discussing for the first time the importance of evolutionary aspects of diet, the omega-6/omega-3 fatty acid ratio and cholesterol intake relative to health and CHD. They also propose measuring blood fatty acids in the population in order to define the risk of CHD and other chronic diseases.This book will be of interest to physicians (cardiologists, gerontologists, and pediatricians), nutritionists, dieticians, health care providers, scientists in industry and government and policy makers.

A Balanced Omega-6/omega-3 Fatty Acid Ratio, Cholesterol and Coronary Heart Disease

The issues treated in this publication are brought together in this way for the first time. For many of the chronic diseases, familial predispositions are well established, and there is good evidence for true genetic predisposition. When Homo erectus emerged 1.7 million years ago, humans existed as non-cereal-eating hunter-gatherers. It is on this basis that, according to the hypothesis of the 'carnivore connection', an insulin-resistant genotype evolved to provide survival and reproductive advantages to populations adapted to a high meat, low plant food (low carbohydrate) nutritional environment. Cereal became the major source of calories and protein in the human diet only about 10,000 years ago. Humankind has thus had little evolutionary experience to adapt to this new food type, maladaption being the consequence. Moreover, studies comparing energy expenditure in Western societies and during the Paleolithic period indicate a low level of physical activity not previously encountered in human history, a state to which humans are not genetically adapted. Together with the dietary changes, this has led to a modern environment in which a number of individuals are prone to chronic diseases, causing increases in non-insulin-dependent diabetes mellitus, hypertension, coronary artery disease, cancer and obesity. As a consequence, the lifestyle approach for the prevention and management of these diseases is essential, varying with national dietary patterns and national economy. This publication will be of special interest to physicians, geneticists, nutritionists, dieticians, anthropologists, food technologists, food-policy-makers and individuals interested in personal and family health.

Diet, Exercise, Genetics, and Chronic Disease

Evolutionary Aspects of Nutrition and Health

Francesco Visioli

"This book is an update of the previous volume on Mediterranean diets published in 2000, which provided extensive reviews of the various diets existing in the Mediterranean region. Since then, a number of studies have been published on the relationship between a 'Mediterranean-type' diet and chronic diseases. However, because the 'diet score' used in those studies does not provide any information on the nutritional composition or quality of the diet, this publication takes an entirely different approach: Particular attention is given to the nutritional factors and their mechanisms in cardiovascular disease, cancer, metabolic syndrome and obesity, and the results of decreasing the [omega]-6:[omega]-3 ratio and its anti-inflammatory effects on several biomarkers are evaluated. Moreover, the effects of olive oil, relative to its antioxidant properties, and the anti-inflammatory and anticarcinogenic aspects of melatonin from plants and fruits common in the Mediterranean region are discussed."--BOOK JACKET.

More on Mediterranean Diets

Leslie G. Cleland

Studies on the evolutionary aspects of diet and molecular studies included in this volume indicate that human beings evolved on a diet that was balanced in the essential fatty acids (EFA). In fact, the ratio of omega-6/omega-3 EFA was 1/1 whereas present day diets in both developed and developing countries have a much higher ratio, between 5/1 and 50/1. Additional studies show that a high ratio of omega-6/omega-3 EFA is detrimental to health and may lead to the development of chronic diseases. Improving the dietary ratio by decreasing the omega-6 fatty acids and increasing the omega-3 fatty acids is essential for brain function and for the management of cardiovascular disease, arthritis and cancer. A ratio of 4/1 or less leads to lower dosage and to the reduction of adverse effects of drugs. This volume should be of interest to a large and varied audience of researchers in academia, industry, and government; cardiologists, geneticists, immunologists, neuroscientists, and cancer specialists; as well as nutritionists, dietitians, food scientists, agriculturists, economists and regulators.

Artemis P. Simopoulos

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