Raj Kumar

Bal Ram Singh

This succinct volume addresses the production of inactive, potentially toxic proteins in the absence of correct protein folding and the resultant neurodegenerative diseases. Other topics include intrinsic disorder in protein structure and function and the effects of molten globules on protein toxicity. This concise and yet thorough text also discusses using toxin structure as a model for studying structural and functional aspects of protein chemistry. Protein Toxins in Modeling Biochemistry, a SpringerBrief, is essential reading for advanced researchers, scientists and advanced graduate students interested in protein chemistry and related areas of biochemistry and molecular science.

Protein Toxins in Modeling Biochemistry

Rattan Lal

David O. Hansen

Lars Olav Eik

David Kraybill

Dismas L. Mwaseba

This 32-chapter volume represents the core of several oral and poster presentations made at the conference. In addition to Introduction and Conclusion sections, the book is thematically divided into 7 sections, namely, 1) Land Use and Farming Systems, 2) Effects of Climate Change on Crop Yield, 3) Soil Nutrient and Water Management for Carbon Sequestration, 4) Rehabilitation of Degraded Lands through Forestry and Agroforestry, 5) Management of Animal Production for Greenhouse Gas Emissions, 6) Smallholder Adaptation to Climate Change, and 7) Economic, Social and Policy Issues. It addresses these themes in the context of sustainable intensification (SI). It implies increasing agronomic production from the existing land while improving/restoring its quality and decreasing the C or environmental footprint. Simply put, SI means producing more from less.

Sustainable Intensification to Advance Food Security and Enhance Climate Resilience in Africa

Andy Safalaoh

Nyambilila A. Amuri

Bishal K. Sitaula

This book discusses knowledge-based sustainable agro-ecological and natural resource management systems and best practices for sustained agricultural productivity and ecosystem resilience for better livelihoods under a changing climate. With a focus on agriculture in Africa, the book assesses innovative technologies for use on smallholder farms, and addresses some of the key Sustainable Development Goals to guide innovative responses and enhanced adaptation methods for coping with climate change. Contributions are based on 'Capacity Building for Managing Climate Change in Malawi' (CABMACC), a five-year program with an overall goal to improve livelihoods and food security through innovative responses and enhanced capacity of adaptation to climate change. Readers will discover more about sustainable crop production, climate smart agriculture, on-farm energy supply from biogas and the potential of soil carbon sequestration in crop-livestock systems.

Climate Impacts on Agricultural and Natural Resource Sustainability in Africa

Anthony T. Tu

From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.

Structure, Mechanism of Action, and Detection

Natural Toxins 2

Bal Ram Singh

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