Brian Henderson

Michael Curtis

Robert Seymour

Nikolaos Donos

This book provides a systems-based approach to periodontology and offers a scientific roadmap of the interactions which can lead to periodontal disease.

Periodontal Medicine and Systems Biology

Mario A. Fares

Andrew C. R. Martin

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

Protein Moonlighting in Biology and Medicine

Tony E. Huntimer

About 700,000 Camaros were built from 1967 to 1969. The first-generation Camaro has won a die-hard following and has become an iconic performance car. Camaros in excellent condition command very high prices, so many owners are compelled to perform a professional-grade original restoration. Since these cars are about 40 years old, many cars need second or third restorations, and as time goes by, these cars will continue to appreciate and require restoration. That's where How to Restore Your Camaro 1967-1969comes in. While some owners can afford to pay shops to perform a 100-point restoration for show car competition, many owners want to perform a faithful, detailed restoration themselves, so the car maintains its collector value and use it as a fun weekend driver. This book will serve those owners. A lead title in our Restoration Series, How to Restore Your Camaro 1967-1969will provide in-depth, hands-on information and photography for restoring these popular and historically significant cars. It covers all aspects of restoration, including engines and drivelines, bodywork, interior and trim, suspension, brakes, chassis, and steering for the first-generation Camaros. Organization and planning will be covered, so restorers can stay on task. Disassembly, inspection, and sourcing the best parts will also be covered. This volume will deliver a concise and revealing overview of each subject area and shows the most critical aspects of the restoration process with sequential step-by-step photos and detailed captions. The most efficient techniques and best products for returning each component to like-new condition will be covered. With this information, owners will be able to determine what's involved in each step of the restoration and decide whether to perform the work themselves or outsource it to a professional shop. Color step-by-step how-to information on Camaro restoration has never been offered in a package like this before. Finally, Camaro owners have the book they need.

How to Restore Your Camaro 1967-1969

M. W. Bodmer

Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ß. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.

Therapeutic Modulation of Cytokines

A. Graham Pockley

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Cellular Trafficking of Cell Stress Proteins in Health and Disease

James F. Brooks

David Grimsted

Tom Grayson Colonnese

Luhr, William

A series of in-depth examinations of the motion picture many consider to be Hollywood's finest western film.

Essays and Reflections on John Ford's Classic Western

The Searchers

Originally published in 2005, this book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

Molecular Chaperones and Cell Signalling

Margaret J. McFall Ngai

Edward G. Ruby

Broad-ranging and cross-disciplinary overview of the evolution and mechanisms of beneficial host-pathogen interactions.

Brian Henderson

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