Bruno Tota

Tommaso Angelone

Maria Carmela Cerra

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.

Chromogranins: from Cell Biology to Physiology and Biomedicine

Guido di Prisco

Bruno Maresca

Biology of Antarctic Fish presents the most recent findings on the biology of fish in the unique environment of the Antarctic ocean. At present the year-round temperature of the coastal waters is very near -1,87 ° C, the equilibrium temperature of the ice-seawater mixture. This extremely low temperature affects different levels of organization of fish life: individuals, organ systems, cells, organelles, membranes, and molecules. Exploring ecology, evolution, and life history as well as physiology, biochemistry, and molecular biology of Antarctic fish the book describes the mechanisms of cold adaptation at all these levels. It provides material for discussion also for fundamental questions in the field of adaptation to an extreme environment and therefore is of particular interest not only to specialized scientists, but also to those involved in basic and evolutionary biology.

Bruno Tota

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