C. David Allis

Thomas Jenuwein

Danny Reinberg

Marie-Laure Caparros

(An) impressive volume. The contributors provide an accurate survey of the field . . . Their accounts help set the stage for deepening our understanding of epigenetic phenomena and mechanisms. And the volume will undoubtedly prove to be very useful for students and researchers alike.--"Science."

Epigenetics

Carl Wu

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volume covers Nucleosomes, Histones & Chromatin and has chapters on Dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA, Digital DNase technology, and Genome-wide Analysis of Chromatin Transition. Contains quality chapters authored by leaders in the field. The volume covers Nucleosomes, Histones & Chromatin. Has chapters on Dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA, Digital DNase technology, and Genome-wide Analysis of Chromatin Transition.

Nucleosomes, Histones & Chromatin

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

C. David Allis

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