Simone Parvez

Claude Reiss

Gilles Labbe

Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.

Advances in Molecular Toxicology

Catherine Collin

Masaru Minami

Hasan Parvez

Hideya Saito

Qureshi

Neuroregulation is a challenging and rapidly developing field that holds the key to many currently intractable medical conditions from nervous and mental diseases to stress-related disorders. Advances in Neuroregulation mirrors the broad scope of research in this area with topics ranging from new concepts on the immune system and on the action of antidepressants to the evolution and development of the autonomic nervous system. In addition, the latest research findings are presented for behavioural disorders and medical conditions such as Parkinson’s disease, Alzheimer’s disease, epilepsy and attention-deficit/hyperactivity disorder. Another area of emphasis is the body's responses to stress and the effect of neuroactive agents in the treatment of stress-related conditions. Many chapters are devoted to the progress being made at the cellular and molecular level, including areas such as: - the conditions for culture of different types of neural cells - conformational diseases and the protein folding problem - vasoactive intestinal polypeptide release from pancreatic islets - the effect of melatonin and corticosterone on macrophages Here, in a book that expands the frontiers of neuroscience, researchers into neuroregulation at the molecular and cellular levels as well as those working at the clinical and systemic levels will find important results relating to their field.

Advances in Neuroregulation and Neuroprotection

Claude Reiss

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