David Khayat

Gabriel N. Hortobagyi

This is the fourth volume of our series Progress in Anti-cancer Therapy. For the past four years we have taken the challenge to select each year, some of the most interesting topics on the wide field of oncology. As usual, this volume continues the tradition and covers five cancers (breast, prostate, bladder, lym phoma and ovarian), the role of HIV and HTLV in cancer, as well as some deve lopmental pharmacology and behavioral issues. This year, we have particularly focused our attention on one of the most com mon (although rarely addressed) cancer accounting for more than 315,00 newly diagnosed cases and 41,000 cancer-related deaths annually (Landis SH et al., 1999) : prostate cancer. Five chapters address some of the issues concerning this disease. The chap ter by Schroder describes the hopes and pitfalls of early detection of prostate cancer. It reviews the literature on screening studies that have been performed both in the US and in Europe. These studies suggest that cancer mortality could be reduced by screening for prostate cancer, mostly through PSA testing. However, the effectiveness of early detection still needs to be definitely confir med and ongoing randomized studies are described, the results of which will probably help the medical community determine the worth of PSA-based scree ning for prostate cancer. On the same hand, the paper from von Eschenbach is reviewing the clinical problems that are related this disease.

Progress in Anti-Cancer Chemotherapy

Didier Buthiau

Virtual endoscopy progressively enters the real world The development of virtual reality is one of the most striking features of our Western societies. Beside chil dren games and movies, its scope has expanded to medical imaging through 3D CT scan surface or volume re constructions. Whatever the site clinicians are able to perform real endoscopy (RE), radiologists can now also provide virtual endoscopy (VE) images. VE enters our medical practice. The next question is to weigh the pros and cons. VE has the unique advantage to offer high-quality images obtained through a noninvasive and well-tolera ted procedure performed in outpatients. Compared to RE, it carries no risk of bleeding, perforation or trans mission of viruses. Importantly, VE can pass high-grade stenoses affecting large bowel, urinary tract or tra cheobronchial tree, and visualize areas hard to visit by optic fibers such as intracranial regions. 3D VE images can be commented with patients, and this might reduce potential misunderstanding and its medico-legal consequences. Last but not least, VE is the sole alternative offered both to those who refuse RE, and to severely ill elderly patients. Then, should we consider VE as the Deus ex machina of modem medical imaging - with CT scan as rna china - ? Clearly, the answer is no, given VE knows severals limits and pitfalls. One of the most important me rits of this book is to discuss honestly these aspects. First, VE will never allow to perform biopsies or resections.

Virtual Endoscopy

Imaging techniques are often called upon in oncology in virtue of their essential role in tumor diagnosis, extension work up to various organs and detection of relapse. They are also indispensable in research and in clinical practice, allowing an objective assessment of tumoral regression in patients undergoing treatment. It is currently impossible to establish the management plan of a cancer patient or to obtain follow-up of such a patient under treatment without clinical and imaging confrontation.

CT and MRI in Oncology

With the huge number of studies on nutrition and cancer available, it's impossible for a person to sort through them all to come up with practical recommendations. Now, Dr. David Khayat, a world-renowned oncologist, has done that hard work for you. In this international bestseller, Dr. Khayat provides easy-to-follow—and often surprising—guidelines on what are now known to be the foods most likely to reduce the risk of cancer. For those of a scientific bent, he explains what cancer is and how it develops. Bringing together his own research with that of other major cancer specialists, he breaks down what the studies mean, which ones provide the most solid evidence, and how to use their results in your and your family’s diet. Structured by the major food groups—as well as supplements, beverages, and exercise—The Anticancer Diet may surprise you by not disparaging red meat but alerting you to find out the source of your fish and suggesting sole over salmon. While highly recommending commercial pomegranate juice, it cautions people with fair hair and eyes against drinking orange juice. What stage of life a person is at will also affect what they should consume. Pregnant women, older women, men, and children may process foods differently. With numerous easy-to-read charts and tables along with a comprehensive food list at the back of the book, this accessible, user-friendly guide helps readers realize the power in their everyday choices.

The Anticancer Diet: Reduce Cancer Risk Through the Foods You Eat

Institut national de la santé et de la recherche médicale (France)

Claude Jacquillat

Marise Weil

This book presents the Proceedings of the Second International Congress on Neo-Adjuvant Chemotherapy which took place on 19 to 21 February 1988 in Paris.

Neo-adjuvant Chemotherapy

Chimiothérapie Néo-adjuvante, Français

This is the third volume of our series Progress in Anti-Cancer Chemo therapy. Following the strategy of the first two volumes, it covers selected aspects of progress in this fast moving field of Oncology, with contribu tions from some of the world's best known leaders in both basic and clin ical research. This year we focused on seven areas: Three prominent Clinical investigators reviewed conceptual advances in cancer research. Dr Buzdar presented a history and overview of the protection of human subjects who participate in clinical research, and the mechanisms developed to assure the ethical conduct of research on human beings. Frei reviewed an exciting and rapidly moving area of che motherapy of solid tumors, including a cogent discussion of the issues related to dose-intensification. Fisher summarized conceptual advances in our therapeutic approach to breast cancer and the paradigm shifts that lead us to our current management strategies. From this summary he pro jected breast cancer research into the future, a daunting task under any circumstance. Fundamental research in cancer biology has been responsible for our improved understanding of the development and progession of malignant disease. Such understanding will lead to improved diagnosis, therapy, and eventually, prevention. Isaacs reviews the area of hereditary breast cancer, a topic undergoing rapid transformation and with mUltiple impli cations in the daily practice of medicine. Fidler, an international expert in metastasis research reviews the potential utility of angiogenesis inhib itors in research and the therapeutic ramifications.

« Promis, demain j'arrête ! » Qui n'a jamais prononcé ces paroles après une soirée trop arrosée, un repas trop copieux, sans parler de la dernière cigarette du paquet ? Les interdits sont partout, d'où cette culpabilité qui s'est généralisée. Il est temps de retrouver notre liberté de santé. De récentes études le confirment : la culpabilité est le pire ennemi de notre santé. Profil par profil, nous allons découvrir ensemble comment il est possible de gérer dans la vie de tous les jours nos péchés mignons et autres excès. Oui, je l'affirme, nos petites faiblesses peuvent devenir nos atouts. Alcool, tabac, sucre, sel, soleil, écrans, tout est possible aujourd'hui. Bien vivre sans se priver n'est pas une promesse, mais votre assurance santé. Si j'y suis arrivé, pourquoi pas vous ?

David Khayat

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