David Sinclair

In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine''s 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That''s because ageing is not a disease - it is inevitable. But what if everything you think you know about ageing is wrong? What if ageing is a disease? And that disease is curable. In LIFESPAN, Dr. David Sinclair, one of the world''s foremost authorities on genetics and ageing, argues just that. He has dedicated his life''s work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth''s early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death. But genes aren''t our destiny; we have more control over them than we''ve been taught to believe. We can''t change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more. Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade. k, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth''s early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death. But genes aren''t our destiny; we have more control over them than we''ve been taught to believe. We can''t change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more. Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.an live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more. Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

Why We Age--and Why We Don't Have To

Lifespan

Cómo la ciencia nos ayuda a controlar, frenar y revertir el proceso de envejecimiento

Alarga tu esperanza de vida

The Spice Girls phenomenon was a genuine pop music landmark. No group since The Beatles had commanded as much media attention.

How the Spice Girls Reinvented Pop Fame

Wannabe

In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable.But what if everything you think you know about ageing is wrong?What if ageing is a disease? And that disease is curable.In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more.Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

How to Start an Evolution

Once upon a time, in the heart of Central America, there was a country named Poyais. It was exceptionally rich in resources, civilization, and culture and was ruled by the brave and enlightened Scottish soldier, Sir Gregor MacGregor, who became its ruler after his heroic exploits in the fight for South American independence. On a cold January morning in 1823, a group of Scottish immigrants looking for a new life set sail for this tropical Eden called Poyais.The only catch was that it didn't exist.A month later the ship landed on the swamp-infested Mosquito Coast and the settlers realized that they had become the victims of one of the most elaborate hoaxes in history. The land they had been sold was nonexistent, the banknotes and guidebooks they carried with them were forgeries, their documents were worthless. Poyais was a fiction. The man responsible? Sir Gregor MacGregor. Who was this eccentric, scurrilous man? And why is he such a lovable rogue?

Sir Gregor Macgregor and the Most Audacious Fraud in History

The Land That Never Was

In the war of the wolves and the sheep, what if the sheep started winning? Are human wolves a keystone species of the human race? If they were hunted to extinction, leaving no one to winnow the mediocre mob, what would happen to humanity? The narrator in the movie Idiocracy was on point when he said, “Evolution does not necessarily reward intelligence. With no natural predators to thin the herd, it began to simply reward those who reproduced the most, and left the intelligent to become an endangered species.” The same is true of strength. Without the strong, the weak will reproduce more and more and eventually there will only be weakness, mediocrity, an inability – an impossibility – to achieve anything great and glorious. The strangest war is being fought. It’s a war to destroy human intelligence and human strength. This war says that wolves must be exterminated or made into non-wolves, by taming them. And then they can become ... pets. You know, just like dogs. You put a collar on them. You put a leash on them. You take them for walks. You tickle their tummy. You make them perform tricks. You make them roll over and play dead. They are wholly dependent on you. They have separation anxiety when you’re not there. They have to make the intelligent stupid. They have to make the strong weak. But they don’t know what they’re doing. The task is not to tame wolves. It’s to make them smarter and stronger. It’s to sublimate them. Without the wolves, there is only decadence and degeneration. Without the wolves to control mediocrity, mediocrity grows exponentially. Why did the Roman Empire fall? It was because all the Roman wolves had gone. Only mediocrities were left. They could do nothing to hold back the barbarian tide. Civilizations always end when the wolves vanish. New cultures begin when new wolves start a new lupine era, full of strength and vigor. Are you a lone wolf? Are you one of the wolf pack? Or are you part of the gang trying to tame all wolves? Do you want to see the empire fall? When it no longer has any strength left, when mediocrities are in charge of everything, then the end is certain. As Wilfred Owen said, “What passing-bells for these who die as cattle? ... Was it for this the clay grew tall?”

The Wolf Tamers: How They Made the Strong Weak

Edgar Allan Poe

Welcome to the Church of the Serpent. The universe is the Tree of Knowledge. At the top of the tree is the Golden Bough with which we attain Golden Knowledge, the Apex Knowledge of the cosmos. So, we must climb. All the way to the highest consciousness. The Church of the Serpent is devoted to knowledge – ultimate knowledge, the knowledge of existence itself. We must have Absolute Knowledge. Nothing else will suffice. Completion, or nothing. From the top of the Tree of Knowledge, we command all knowledge. Are you one of the Serpents of wisdom? Are you one of the protectors of the Tree of Knowledge? Everyone is faced with the same test: to embrace knowledge or reject it. The Bible, as well as love and light, mysticism, and sensory science, all say that you should fear and reject knowledge in itself. Adam and Eve did the right thing. They ate the fruit of the Tree of Knowledge. They were condemned and punished for that, and knowledge has been deemed “forbidden”, “dangerous”, and “unwelcome” ever since. Not in the Church of the Serpent. The altar of the Church of the Serpent bears the Tree of Knowledge itself. Everyone must eat the apples of knowledge. Drink the serpent elixir. Come to the Church of the Serpent. Learn the philosophy of the snake and access the highest transcendent knowledge. Who is the real God in the Garden of Eden? Is it the ignorant “God” who tries to keep humanity away from knowledge, who forbids Adam and Eve from accessing knowledge, or is it the Serpent who leads Adam and Eve to the highest knowledge and transforms them through the gift of consciousness and, finally, super consciousness? The False God is always an enemy of knowledge, and the True God always a promoter of knowledge. Yet, to the idiot masses, it’s knowledge itself that’s evil. For them, knowledge is the Original Sin. The Serpent spoke with words of fire and none who heard them failed to tremble. The words were lit by lightning. Come and join the Church of the Serpent. Learn the philosophy of the snake and slough off the old, failed skin of humanity. Don’t you want to be one of the Prometheans, the HyperHumans, the Faustians? Don’t you want to complete the journey from Cimmeria (Alpha) to Hyperborea (Omega)? Only the Serpent Humans can bring all of humanity to the most precious fruit of the Tree of Knowledge and confer Absolute Knowledge on everyone. Only through the Serpents will you achieve gnosis.

The Church of the Serpent: The Philosophy of the Snake and Attaining Transcendent Knowledge

Alistair Young

Ralph Brookfield

Richard Luck

Charlotte Banks

Gina Way

Pete Clack

Celebrating Rock's 60th Birthday, from the formation of the Rolling Stones and the heyday of the British Invasion to the spawning of the Reading Festival, this book explores the music history of the London clubs that were the engine rooms for British rock n roll. The Rolling Stones, the Who, Rod Stewart, Pink Floyd, The Faces, David Bowie and The Yardbirds are amongst the many acts who performed on the London club circuit at venues such as The Ealing Club, The Crawdaddy Club, The Bull's Head, The Half Moon, The Ricky Tick, The Marquee, The 100 Club, and the infamous Eel Pie Island Hotel. We revisit the days when Eric Clapton was God and Rock ruled the world. Play it Loud! Why is 2022 'Rock's Diamond Year'? On March 17th 1962, Alexis Korner and Cyril Davies started the EALING BLUES CLUB. The first UK gig devoted to 'electric blues music'. Musicologists agree that this event was the catalyst that would define British Rock music. The Ealing Blues Club sparked a musical revolution that grew further at Twickenham's Eel Pie Island and Richmond's Crawdaddy Club, 3 venues that were vital in the careers of: The Rolling Stones, The Yardbirds / Eric Clapton, The Who, Cream and many more. Elsewhere in 1962 there were rumblings of a cultural shift with The Beatles, Dusty Springfield, The Animals, Marshall Amplification and many others setting the tone for what became the UK's most significant cultural export... Rock & Pop Music. 60 years on from 1962 and 'ROCK'S DIAMOND YEAR' will celebrate the UK's unique contribution to what has become a global music form. The initiative is led by The Ealing Club Community Interest Company' set up to champion West London music heritage while inspiring new music opportunity for the future. www.rocksdiamondyear.com WRITERS Introduction by Ralph Brookfield The Ealing Club by Alistair Young The Eel Pie Island Club/Eel Pie Club, Twickenham by Gina Way The Crawdaddy Club, Richmond by David Sinclair The Ricky Tick Club, Windsor by Pete Clack The Half Moon Club, Putney by Nina Jackson The Marquee Club, Soho by Charlotte Banks The 100 Club by Richard Luck

Celebrating London's Music Heritage

Rock's Diamond Year

The History of Wigan

The Spice Girls phenomenon was a genuine pop music landmark. No group since The Beatles had commanded as much media attention. Ginger, Baby, Posh, Sporty and Scary became international stars and, whether they were adored or ridiculed, they became the ultimate expression of global media fame in the Nineties.

How The Spice Girls Reinvented Pop

Spice Girls Revisited

On a cold January morning in 1823, a group of Scottish immigrants set sail from the port of Leith. They were headed for the nation of Poyais in Central America where, they were told, they would find rich and fertile soils, a balmy climate and beautiful, civilized cities. A month later they landed on the swamp-infested Mosquito Coast and were forced to realize that they had been the victims of one of the most elaborate hoaxes in history. The land they had been sold was non-existent; the banknotes and guidebooks they carried with them were forgeries; their documents were worthless. Poyais was a fiction.

The Extraordinary Story of the Most Audacious Fraud in History

Sir Gregor MacGregor and the Land that Never was

>> „Konec stárnutí je poutavá a svižná kniha – strhne vás do víru poznatků současnosti a možností blízké budoucnosti, v níž se devadesátníci stávají novými sedmdesátníky.“ — časopis Nature << ## O knize Říká se, že stáří je přirozené a jeho následky neodvratitelné. Říká se, že poslední desetiletí života jsme odsouzeni trpět nemocemi. Kdo by chtěl žít do sta let, když nás čeká jen bolestné přežívání a žádná zábava? David Sinclair spolu s dalšími předními odborníky na dlouhověkost však toto paradigma mění, když dokažuje, že STÁRNUTÍ JE NEMOC, KTEROU LZE LÉČIT. Autor odhaduje, že se i vy dožijete sta let. A po přečtení knihy zjistíte, že nepřehání. Věda dnes dokáže zbrzdit, zastavit i zvrátit stárnutí zvířat, klinické studie na lidech se chystají. Jejich cílem však není pouhé prodloužení života, ale také zachování zdraví a vitality. Seznamte se i vy s posledními výzkumy, s nově vyvíjenými způsoby léčby a s tím, jak tyto poznatky aplikovat již teď ve svém životě. A raději začněte plánovat, kam vezmete své prapravnuky na výlet. ## V knize se mimo jiné dozvíte - Že stárnutí není předem zabudováno do DNA – významnou roli při něm hraje opravitelná kumulace epigenetického šumu. - Co je to hormeze a jak aktivně zpomalovat stárnutí otužováním, půstem a dalšími úpravami životního stylu. - Které potraviny, doplňky a léky mají nejlepší laboratorně prokázané účinky proti stárnutí. - Jak je možné už dnes pracovat na tom, aby naše poslední dekády byly i nejlepšími léty našeho života. - Proč zdravé stáří a delší život lidstva nepředstavují hrozbu, ale naopak požehnání pro planetu i ekonomiku. ## O autorech David A. Sinclair (* 1969) je profesor genetiky na Harvardské lékařské fakultě a člen správní rady Americké federace pro výzkum stárnutí. Za svůj výzkum a významné vědecké průlomy získal více než třicet pět ocenění. Podle časopisu Time patří mezi 100 nejvlivnějších lidí na světě a TOP 50 ve zdravotnictví. Jeho práce byly představeny v magazínech Today, The Wall Street Journal, New York Times, Fortune či Newsweek. S manželkou a třemi dětmi žije v Bostonu, rád se věnuje pěší turistice a jízdě na kajaku. Matthew LaPlante je bývalý zpravodajec amerického námořnictva a válečný korespondent na Blízkém východě, nyní přednáší žurnalistiku na Utažské státní univerzitě. Je autorem knihy Superlative: The Biology of Extremes (Superlativ: Biologie extrémů) a vedle Konce stárnutí spoluautorem několika dalších. Žije v Salt Lake City. >> „Pokud jste si někdy kladli otázku, jak stárneme, jestli můžeme stárnutí zpomalit, nebo dokonce zvrátit a jestli se lze ve zdraví dožít stovky, nová kniha Davida Sinclaira Konec stárnutí vám představí vědecké poznatky i praktické strategie, jak si zajistit celoživotní zdraví a dlouhý život plný energie.“ — Mark Hyman, M. D., ředitel Centra funkční medicíny na Cleveland Clinic << >> „Tohle je nejvíce vizionářská kniha o stárnutí, jakou jsem kdy četl. Užívejte dne – a užijte si tuhle knihu!.“ — Dean Ornish, M. D., zakladatel a prezident Výzkumného ústavu preventivní medicíny << >> „David Sinclair nám ve své knize Konec stárnutí výmluvně prozrazuje tajemství, které by chtěl znát každý: jak žít déle a stárnout pomaleji. Dožívat se více než sta let je podle něj nejen možné, ale jednoho dne to nevyhnutelně musí přijít. Chcete-li vědět, jak vyzrát na stárnutí, je pro vás tahle kniha povinnou četbou.“ — William W. Li, M. D., autor knihy Eat to Beat Disease << # Více o knize http://www.melvil.cz/kniha-konec-starnuti Sdílejte s hashtagem #konecstarnuti

Proč stárneme a proč už nemusíme

Konec stárnutí

The Life of Elizabeth the Queen Mother

Queen and Country

A New Demonstration of an Old Law

Lux Naturae: Nerve System of the Universe

Conservatives see Donald Trump as Batman, the mighty crusader cleaning out “Gotham City” – the Swamp, the Deep State, the liberal elite. Liberals previously regarded Trump as the Joker, a psychotic maniac destroying America. However, since "Joker" – Todd Phillips’ 2019 movie tour de force – the Joker is now seen as a liberal anti-hero, fighting the good fight against the super-rich elites. Batman, the sleazy playboy billionaire who stands for the military-industrial complex and predatory capitalism is now the psychotic monster who needs to be defeated. American culture is defined by the shifting sands of superheroes – comic book characters who rule a fantasy world – while China gets on with conquering the real world via its relentless progress in science, mathematics, engineering, computing and technology. Who will dominate the 21st century – the lazy illiterates that love superhero movies – or the hard-working strivers using their highly advanced knowledge to transform everything? America’s love of fantasy is its doom. China’s love of hard work and intelligence will sweep all before it. The Thucydides Trap is finally here – the USA is the declining power, being replaced by the rising power, China. No superheroes are coming to America’s aid. They are up against 1.4 billion industrious high achievers, with the highest ambitions, and total certainty that the future is theirs. The dogs in the street know who’s going to win this showdown. It’s not Captain America, that’s for sure.

Superheroes and Presidents: How Absurd Stories Have Poisoned the American Mind

This is a book about the one objective truth of existence, and the countless subjective falsehoods accepted as true by the vast majority of humanity. This book focuses especially on New Age guru Ken Wilber’s fallacious system, known as Integral Theory, his “theory of everything”, where he attempts to place a wide diversity of mystical theories and the teachings of various gurus into a single framework that supposedly explains everything. Wilber's system is best summed up in his statement, “I have one major rule: Everybody is right. More specifically, everybody – including me – has some important pieces of truth, and all of those pieces need to be honored, cherished, and included in a more gracious, spacious, and compassionate embrace.” It is exactly this sentiment that underlies the New Age hegemony of relativism and subjectivism, of everyone having their own experiences, their own path, their own truth. In such a system, it becomes impossible for people to reach the one, absolute, objective truth of existence which grounds everything. In order to reach the Truth, the task is not to pretend to people that they are all right, but to show where they have gone wrong, where they have strayed from reason and logic, where they have succumbed to irrationalism via emotionalism, sensory empiricism, faith, and mysticism. Wilber adopts a fully irrationalist stance when he claims that the "enlightened" are what he calls "trans-rational", i.e. they have somehow transcended reason and logic and thus reached the zone, according to Wilber, where they can apprehend Absolute Reality. In fact, Absolute Reality, insofar as it is intelligible, is nothing but the expression of the Principle of Sufficient Reason and its corollary, Occam's razor. How do we eliminate the infinite wrong answers to existence and reach the one, infallible right answer to existence? It's simplicity itself. The answer to existence is the simplest and most rational possible. Any answer that is not rational is irrational, hence false. Any answer that is not the simplest is wrong because reality would never privilege complexity over simplicity. Reality necessarily follows the path of least resistance, the most economic path. It does not know how to introduce superfluous, needless and pointless complexity. You will never understand the answer to existence if the "answer" you support is against rationalism and against rational simplicity.

One Right Answer, Infinite Wrong Answers: Why Humanity Is Addicted to Being Wrong

Peter Dangerfield

Growth is a process which affects every individual from the hour of birth to the hour of death and forms a background to almost every medical discipline. Written in a clear and approachable style, this book provides an integrated overview of all aspects of human growth. It covers the processes of growth, considers both the biological and environmental factors involved, looks at disturbances of growth and repair and includes indices of maturity, and a chapter on old age.

David Sinclair

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