Donald W. Pfaff

how we are naturally good

The altruistic brain

Philippe Chanson

Claude Kordon

SocialBonding,aProductofEvolution: anIntroductiontotheVolume Mechanisms underlying reproductive and maternal functions or coping represent the initialstructuringforcebehindmanysocialbehaviors.Theyareaccompaniedbysel- tivehormonalenvironmentsaimedatfacilitatingor stabilizingthem.Sexandadrenal steroids are major players in the regulation of reproductive functions and coping challenges, but other hormones also participate in a variety of social behaviors (in particular,oxytocinandvasopressin,twophylogeneticallyveryoldmoietiesoriginally associated with maternal care and water balance) and are receiving increasing att- tion. Their role is highlighted in the present volume, which gathers contributions to theColloqueMédicineetRecherche“HormonesandSocialBehavior”organizedbythe FondationIPSENinDecember 2007. Whatisthekeytounderstandingtherationaleofhormonalsubstratesofbehavior? Evolution, of course. Higher manifestations of social behavior have evolved from - productivebehavior,characterizedbyErnstMayras“theleadingedgeofevolutionary change.” As formulated by one contributor to thisvolume, however, “the evolutionary increase in neocortex seen in primates has induced a signi?cant emancipation of - havior from hormonal determinants, and in parallel, an increasing role for intelligent socialstrategies”(Keverne 2008). In so-called “lower” mammalian animals, many social behaviors are closely - pendent upon the olfactory system, a component of autonomous regulation of such importancethatitexpressesalargeproportionofallreceptorgenespresentinthebrain. Whenonelooksat“higher”mammalssuchasprimates,olfactorycontrolbecomesless stringent. Olfactory structures exhibit the same number of receptor genes, but a large number are transformed into non-coding “pseudogenes.” In parallel, hormones i- tially targeted on physiological functions become increasingly associated with more diversi?edcognitivefunctions.

Hormones and Social Behavior

Robert H. Rubin

A single volume of 41 articles, Hormone/Behavior Relations of Clinical Importance is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP July 2009). The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of hormone-brain function, hormone-behavior relations, sex differences, and the impact on various diseases/pathologies. Many basic human behavioral functions are subject to the influence of hormones - sexual orientation, the experience of pain, fertility, immunity - as are clinical conditions such as diabetes, substance abuse disorder, eating disorders, PTSD, TBI, pain, Alzheimer's, stress/anxiety, affective disorders, and more. There is considerable commercial clinical potential in the study of hormones - drug companies are currently developing a Cholecystokinin (hormonal peptide) booster to reduce appetite in those who suffer from sever obesity, and catamenial epilepsy (features seizure exacerbation in relation to the menstrual cycle) is resistant to treatment by standard antiepileptic medications, but may be hormonally controlled. These issues and more are covered, and there is simply no other current single-volume reference with such comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 150 figures (50 in color). A collection of articles reviewing our fundamental knowledge of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area. - Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 25% of chapters are written by international contributors (7 countries represented) - Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions - Heavily illustrated with 150 figures, approximately 50 in color, presenting the material in the most visually useful form for the reader - Fully explores various clinical conditions associated with the hormones and the brain (PTSD, TBI, Stress & Anxiety, eating disorders, diabetes, addictive disorders, Alzheimer's, affective disorders) - Broad coverage of disorders makes the volume relevant to clinicians as well as researchers and basic scientists

Endocrine Systems Interacting with Brain and Behavior

Hormone/Behavior Relations of Clinical Importance

Nora D. Volkow

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

From Basic to Clinical

Neuroscience in the 21st Century

John L. Rubenstein

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its third edition serves as a comprehensive resource to students and researchers alike.

Genes and environment interact inside and outside the brain to produce hormonal and neuroanatomical and neurochemical differences between men and women. These factors dictate small differences in ability and large sex differences in feelings, in pain and in suffering.

An Inside Story

Man and Woman

M. Ian Phillips

Robert T Rubin

This text introduces underlying principles of the endocrine regulation of behavior in animals and humans. Every chapter begins by stating a principle, followed by specific examples of hormone actions derived from scientific experiments and clinical observations, and concludes with a few challenging unanswered questions. The reference source Hormones, Brain & Behavior identified this field as rapidly expanding within neurobiology and endocrinology. Now, this well-illustrated and referenced text will serve students from undergraduate school to medical school as they learn this new discipline. * Uniform presentation of material across all chapter, with each chapter addressing a key principle, illustrated by basic experimental and clinical examples * Includes user-friendly features such as boxed figures with extended captions and references, numerous clinical notes, and a comprehensive list of abbreviations * Illustrations highlight both the clinical and basic science information

Principles of Hormone/Behavior Relations

Wade H. Berrettini

Tong H. Joh

Stephen C. Maxson

Utilizing the flood of information derived from the Human Genome Project and corresponding efforts to elucidate the mouse genome, Genetic Influences on Neural and Behavioral Functions provides a scholarly catalog, organized logically, of relations between the expression of specific genes, nerve cell biology and behavior, normal and abnormal, in animals AND humans. Sample topics include genes in relation to schiziphrenia, panic disorder, epilepsy, alcoholism, sleep, eating disorders, and more.

Genetic Influences on Neural and Behavioral Functions

This book concentrates on two major topics: firstly, the molecular and neural biology of hormone actions relevant to normal social behaviors; and secondly, the clinical treatment of human patients in whom these behaviors have gone wrong.

David S. Pisetsky

Karin Schenck-Gustafsson

Paula R. DeCola

A new vision to understanding medicine Gender medicine is an important new field in health and disease. It is derived from top-quality research and encompasses the biological and social determinants that underlie the susceptibility to disease and its consequences. In the future, consideration of the role of gender will undoubtedly become an integral feature of all research and clinical care. Defining the role of gender in medicine requires a broad perspective on biology and diverse skills in biomedical and social sciences. When these scientific disciplines come together, a revolution in medical care is in the making. Covering twelve different areas of medicine, the practical and useful Handbook of Clinical Gender Medicine provides up-to-date information on the role of gender in the clinical presentation, diagnosis, and management of a wide range of common diseases. The contributing authors of this handbook are all experts who, in well-referenced chapters, cogently and concisely explain how incorporation of gender issues into research can affect the medical understanding and treatment of heart disease, osteoporosis, arthritis, pain, violence, and malaria among other conditions. This intriguing and unique medical textbook provides readers with a valuable new perspective to understand biology and incorporate gender issues into the different branches of medicine.

Handbook of Clinical Gender Medicine

Hormones, Brain and Behavior

Richard J. Bodnar

Kathryn Grace Commons

"Explores the authors' novel and provocative hypothesis that neural mechanisms controlling reproductive behavior and pain are intricately intertwined." -- Karen J. Berkley, Ph.D., Florida State University

Donald W. Pfaff

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