Eric Nguyen

"This is a Borzoi Book published by Alfred A. Knopf"--Title page verso.

A Novel

Things We Lost to the Water

Rick Remender

Originally published in single magazine format by Image Comics as Strange Girl issues 1-18, in 2005.

Strange Girl Omnibus

Duane Swierczynski

Patrick Thorpe

Dark Horse

X Volume 2

Dogs of War

Big Bad

Daniel Knauf

Charles Knauf

Manifest Destiny

Eternals

Mike Hollingshead

This book follows Hollingshead and Nguyen on 17 storm chases through Tornado Alley, illustrating the unfolding events with sequential photographs and featuring a running commentary that relays the fear and fascination implicit of the chasers themselves.

The Storm Chasers

Adventures in Tornado Alley

From surreal skyscapes to wholesale destruction: the most dramatic scenes from the natural world. The destructive power of nature has always been a source of fear and fascination, and never more so than now, when climate change and extreme weather conditions are constantly in the news. Across the central United States, the infamous storms of Tornado Alley are fueled by the collision of cold fronts from Canada and warm fronts from the Gulf of Mexico. People have been chasing these storms for decades in pursuit of thrilling experiences, but now a new generation of storm chasers is combining scientific knowledge with powerful images. This book follows Mike Hollingshead and Eric Nguyen on seventeen chases through Colorado, Iowa, Kansas, Nebraska, New Mexico, Oklahoma, and South Dakota, illustrating the unfolding events with sequential shots and a running commentary by the chasers themselves. These spectacular storm portfolios are expanded with special features on weather phenomena like hail and mammatus clouds plus insights into forecasting and research.

Features dramatic photography of tornadic systems as captured by the authors during seventeen storm chases throughout the American Midwest, in a series of weather portfolios that features sequential shots, running commentary, and complementary information about such phenomena as hail, mammatus clouds, and forecasting technology. Original.

Fred Van Lente

Pascal Alixe

Sara Pichelli

Daniel Acuña

Une silhouette gigantesque apparaît dans la baie de San Francisco. Il s'agit de celle d'un membre d'une race extraterrestre responsable de l'évolution sur notre planète et de la création des Éternels, des êtres puissants et immortels. Vénérés comme des dieux depuis des siècles, les Éternels avaient disparu. Mais ils sont désormais de retour, tout comme les Célestes. Le jour du jugement approche pour l'humanité. Ikaris et Théna sont à la recherche de leur famille dans une course contre le temps désespérée, contée par Charles et Daniel Knauf, et illustrée par Daniel Acuña et Eric Nguyen.

Les Éternels (2008) : Braver l'apocalypse

RNA-binding proteins play a number of important roles throughout the cell. In order to more closely investigate their activity, we have adapted high-throughput techniques to characterize their activity across the transcriptome. We have previously identified heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 as a potential adaptor protein for interactions between the chromatin silencing complex PRC2 and the RNA HOTAIR. We used enhanced cross- linking immunoprecipitation (eCLIP) to map the complete set of direct interactions between hnRNP A2/B1 and RNA in breast cancer cells. Surprisingly, a strong A2/B1 binding site occurs in the third intron of HOTAIR, which interrupts a known RNA- RNA interaction hotspot and is retained at a higher frequency than other HOTAIR introns. In vitro eCLIP experiments suggest that A2/B1 may redistribute to exonic binding sites once this intron is spliced. A2/B1 associates with multiple lncRNAs at regions that may contribute to regulation. Finally, we performed cellular fractionation to characterize the pattern of RNA association of A2/B1 in chromatin, nucleoplasm, and cytoplasm. We also examined the potential relevance of hnRNP A2/B1 in myogenesis. As A2/B1 has been associated with a number of muscle diseases, we performed eCLIP on A2/B1 in both undifferentiated mouse myoblasts and differentiated myotubes. We found that A2/B1 binds the 3′ UTR of transcripts in differentiated cells, and that these transcripts tended to be protein-coding. We also performed eCLIP on another protein, TDP-43, that has been shown to directly interact with A2/B1 and be dysregulated in many of the same diseases. This experiment identified a number of exonic binding sites in myogenesis-associated transcripts, indicative of a role for TDP-43 in the nuclear export of long RNAs during myogenesis. Comparison of A2/B1 and TDP-43-bound transcripts shows some overlap, suggesting that they may act cooperatively in RNA regulation during myogenesis. Finally, we developed a novel method to investigate heterochromatin- associated RNA called hmRIP-seq, which was designed to differentiate between RNA-enzyme interactions leading to heterochromatin formation, and those that do not. This method identified a potential heterochromatin-interacting noncoding RNA, MTRNR2L12, that may direct silencing towards repetitive elements with similar sequence.

Eric Nguyen

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