Andreas J.R. Habenicht

Gotthard Schettler

Atherosclerosis still affects over 50 % of the population in the highly industrialized countries. This book is an update of the treatment of hyperlipidemia, necessary due to the identification in recent years of molecular mechanisms of atherogenesis. Emphasis is on the disease etiology of arteriosclerosis, the treatment of associated or causing diseases and treatment by dietary means or hypolipidemic drugs.

Principles and Treatment of Lipoprotein Disorders

Heiner Greten

International experts review the molecular biology of ion channels, diseases of the central nervous system including Alzheimer's disease, the molecular biology of atherogenesis, plasma lipproteins, lipid transport, long chain fatty acid transport and metabolism, and lipoprotein receptors. Future directions and perspectives and common features in these important areas are discussed.

Selected Aspects

Cellular Metabolism of the Arterial Wall and Central Nervous System

Adam Schneeweiss

Cardiovascular drug therapy has markedly progressed in the recent decades. Not only have new drugs been introduced to clinical practice, but new classes of drugs have been developed. While in 1960 the practicing cardiolo gist had a selection of about only ten drugs, in 1987 about 150 drugs are routinely used in cardiovascular diseases. Elderly patients, however, usually do not enjoy the full benefit of this progress. This might be due to lack of knowledge, a conservative approach, or the worldwide tendency not to try new drugs in the elderly. It is now clear that the majority of patients that will be treated in car diovascular clinics will be, in the near future, elderly patients. Even now, elderly patients form about one-third of the patients with cardiovascular diseases. These patients are approached, however, according to criteria devel oped for younger populations. This is despite the fact that elderly patients differ from younger ones in most aspects, including pathology, epidemiol ogy, pathophysiology, diagnostic approach, management, pharmacology, pharmacokinetics, rehabilitation, and supportive treatment. It is the purpose of this book to present to the clinician all drugs with which there is clinical experience in the elderly or which might be potentially useful for the elderly with cardiovascular diseases. The data are presented without the authors taking a position. This should allow the clinicians to make their own selection and individualize treatment, vii viii Preface based on a wide data base. Comparative data are presented only when specific comparative studies were performed.

Cardiovascular Drug Therapy in the Elderly

Leonore Arab

Marion Wittler

The limited resources available for chemical analyses of components of interest in food has forced scientists to bor row data from published food composition works of other countries. Due to language barriers, this is often undertaken without due knowledge of the background and the instruc tions for use. This collection of introductions, translated in to English, of frequently cited, published food tables has been compiled with the assistance and cooperation of many collaborators throughout the world. We hope that the result will facilitate a more appropriate and extensive use of foreign food tables for scientific purposes. Lenore Arab Marion Wittler Gotthard Schettler Introduction The following is a compilation of the introductory material included in the most recent edition of 19 of the published food composition tables of 14 European countries. In most cases these translations were graciously provided by the pro ducers of the tables or native-speaking people working closely with the information concerned. Recognition of the authors is given on each of the title pages. The title page also includes full publication details of the various tables and summary information on the number of foods contained in the latest edition as well as the number of food components within the tables. It should be noted that a complete list of components is not always given for each food, either because the component is not present, or data is not avail able.

European Food Composition Tables in Translation

Ätiologie, Pathologie, Klinik und Therapie

Arteriosklerose

Dieter Marme

Die Pathogenese der Arteriosklerose ist immer noch weitgehend ungeklärt. In jüngster Zeit zeichnet sich jedoch ein wesentlicher Fortschritt im Verständnis der zugrundeliegenden kausalen Ereignisse ab. Das Entstehen arteriosklerotischer Läsionen beruht mit hoher Wahrscheinlichkeit auf einer Fehlsteuerung der interzellulären Kommunikation, die zum Verlust der Gefäßwandhomöostase führt. In einem komplexen Wechselspiel sind hieran hauptsächlich Wachstums- und Differenzierungsfaktoren beteiligt, deren biologische Funktion derzeit intensiv erforscht wird. Dieses Buch enthält eine Bestandsaufnahme über die zentrale Rolle dieser Wachstums- und Differenzierungsfaktoren beim Entstehen der Arteriosklerose. Es vermittelt Anstöße für grundlegende Forschungen auf diesem Gebiet, um zu neuen Therapiekonzepten im Kampf gegen die Arteriosklerose zu gelangen.

Wachstumsfaktoren und Onkogenprodukte bei Entstehung und Regression der Arteriosklerose

Konrad Beyreuther

Molecular Mechanisms of Aging

The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the pathological process of atherosclerosis. The topics included cover: lipoproteins and lipoprotein receptors; growth factors; endocytosis and exocytosis; ONC Genes and proliferative disease; white blood cells; prostaglandins and leukotrienes; and the biology of smooth muscle and endothelium. The volume provides a complete summary of the most important developments in the field with great impact for arteriosclerosis research.

Gotthard Schettler

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