George Poste

Gregory Gregoriadis

Judith Senior

Targeting of drugs via carrier systems to sites in the body in need of pharmacologic intervention is a rapidly growing area of research in the treatment or prevention of disease. It has evolved from the need to preferentially deliver drugs, enzymes, vitamins, hormones, antigens, etc. to target cells and organs so as to avoid toxicity, waste of drugs through premature secretion or inactivation and at the same time render treatment more convenient and cost-effective. A wide assortment of naturally occ urring or semi-synthetic drug carriers (e. g. antibodies, glycoproteins, lectins, peptide hormones, cells and liposomes), their inter action with relevant receptors and mediation of optimal pharmacological action were discussed in the two previous NATO Advanced Studies Institutes (ASI) of this series, "Targeting of Drugs" and "Receptor-Mediated Targeting of Drugs", the proceedings of wh ich were published by Plenum in 1982 and 1984 respectively. This book contains the proceedings of the 3rd NATO ASI "Targeting of Drugs with Synthetic Systems" held as be fore at Cape Sounion, Greece during 24 June-5 July 1985. It deals mostly with man-made carriers such as a variety of polymers, matrices, liposomes and other colloidal micro particles. The twenty chapters discuss the interaction of such carriers with the biological milieu, approaches to bypass the reticuloendothelial system (or, when needed, take advantage of its interception of carriers to optimally deliver drugs to phagocytes) and ways to improve delivery to specific cells, often with the help of carrier-linked ligands.

Targeting of Drugs With Synthetic Systems

Sixty contributions on liposomes and their uses in drug delivery. Conventional use of drugs suffers from indiscriminate drug action leading to side effects; failure of drugs to reach areas in need of pharmacological intervention; and premature drug inactivation and secretion. This book describes how liposomes incorporating drugs can direct these to diseased areas (in isolation from non-target biological areas) and introduce drugs to areas otherwise inaccessible. Discusses the interaction of liposomes with the biological milieu in vitro and in vivo, ways of optimizing liposomal behavior by manipulation of the carrier, applications related to antimicrobial and cancer therapy, vaccines, enzyme therapy, metal detoxification, diagnostics, and more.

Recent Trends and Progress

Liposomes as Drug Carriers

Brenda McCormack

Anthony C. Allison

Proceedings of a NATO ASI held at Cape Sounion Beach, Greece, June 24-July 5, 1992.

The Role of Basic Immunology

New Generation Vaccines

Liposome Technology, Second Edition, is an updated, expanded new edition of a classic volume in the field. It covers all aspects of liposome technology, including liposome preparation and analysis, drug entrapment, and techniques used for in vivo and in vitro evaluation of liposomes. Leading authorities have contributed 70 chapters to create what is destined to be the standard liposome technology book for the 1990s. Many of the chapters describe methodologies practiced in authors' laboratories and provide specific examples of how these methodologies are applied in specific circumstances. Liposome Technology, Second Edition will be an essential reference volume for academic and industrial researchers in pharmacology, pharmacy, medicine, biochemistry, and immunology. What's new in the 2nd Edition? The 2nd Edition covers significant developments in liposome technology that have occurred since the publication of the 1st Edition in 1982. These developments include the following: New preparative procedures Special approaches to accommodate the incorporation of certain drugs New targeting techniques Large scale production of liposomes, patents, and clinical trials

Liposome Technology, Second Edition

Alkinoos, an Athenian boy, is growing up in the shadow of Parthenon, in his own innocent world. It is the 1930s and Greece is ruled by the dictator Ioannis Metaxas. In October 1940 Mussolini demands passage of his armies through Greece. Metaxas refuses and Italy declares war. The Greeks are victorious, pushing the Italians back. Seeing his Axis ally Mussolini humiliated, Hitler invades Greece. The dreamy world of Alkinoos turns into one of brutal occupation, of famine and executions. This is a story of the boy’s coming of age, of romance with the enemy, a German girl, a Circe with violet eyes. It is a story of things that are not what they seem to be. Of daring undertakings under the nose of the Gestapo, of Odyssean heroism, wiliness and wisdom… and of eventual tragedy. An ancient Hellenic world of pathos and nobleness revisited and relived. Still the Cicadas Sing is the story of a boy’s spirited survival within a world of darkness and pervading death. It is a literary novel that will take the reader on a fascinating journey in Nazi occupied Athens, blending the history of Greece of that period, a little known chapter of the War, with adolescent love, with passion and intrigue.

Gregory Gregoriadis

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