Hans-Jörg Rheinberger

Arguing for the primacy of the material arrangements of the laboratory in the dynamics of modern molecular biology, the author develops a new epistemology of experimentation in which research is treated as a process for producing epistemic things.

Synthesizing Proteins in the Test Tube

Toward a History of Epistemic Things

J. Renn

F.L. Holmes

This is the first book that addresses the issue of research notes for writing history of science in a comprehensive manner. Its case studies range from the early modern period to present and cover a broad range of different disciplines. The contributions are based on papers presented at the workshop entitled "Reworking the Bench: Laboratory Notebooks in the History of Science", held at the Max Planck Institute for the History of Science in Berlin or written after the workshop.

Research Notebooks in the History of Science

Reworking the Bench

An Epistemology of the Concrete brings together case studies and theoretical reflections on the history and epistemology of the life sciences by Hans-Jörg Rheinberger, one of the world’s foremost philosophers of science. In these essays, he examines the history of experiments, concepts, model organisms, instruments, and the gamut of epistemological, institutional, political, and social factors that determine the actual course of the development of knowledge. Building on ideas from his influential book Toward a History of Epistemic Things, Rheinberger first considers ways of historicizing scientific knowledge, and then explores different configurations of genetic experimentation in the first half of the twentieth century and the interaction between apparatuses, experiments, and concept formation in molecular biology in the second half of the twentieth century. He delves into fundamental epistemological issues bearing on the relationship between instruments and objects of knowledge, laboratory preparations as a special class of epistemic objects, and the note-taking and write-up techniques used in research labs. He takes up topics ranging from the French “historical epistemologists” Gaston Bachelard and Georges Canguilhem to the liquid scintillation counter, a radioactivity measuring device that became a crucial tool for molecular biology and biomedicine in the 1960s and 1970s. Throughout An Epistemology of the Concrete, Rheinberger shows how assemblages—historical conjunctures—set the conditions for the emergence of epistemic novelty, and he conveys the fascination of scientific things: those organisms, spaces, apparatuses, and techniques that are transformed by research and that transform research in turn.

Twentieth-Century Histories of Life

An Epistemology of the Concrete

Staffan Müller-Wille

Few concepts played a more important role in twentieth-century life sciences than that of the gene. Yet at this moment, the field of genetics is undergoing radical conceptual transformation, and some scientists are questioning the very usefulness of the concept of the gene, arguing instead for more systemic perspectives. The time could not be better, therefore, for Hans-Jörg Rheinberger and Staffan Müller-Wille's magisterial history of the concept of the gene. Though the gene has long been the central organizing theme of biology, both conceptually and as an object of study, Rheinberger and Müller-Wille conclude that we have never even had a universally accepted, stable definition of it. Rather, the concept has been in continual flux—a state that, they contend, is typical of historically important and productive scientific concepts. It is that very openness to change and manipulation, the authors argue, that made it so useful: its very mutability enabled it to be useful while the technologies and approaches used to study and theorize about it changed dramatically.

From Genetics to Postgenomics

The Gene

Die fünf unter diesem Titel versammelten Arbeiten kreisen alle um das Moment des Suchens und des Unvorwegnehmbaren im Vorgang wissenschaftlicher Forschung. Ihre Entstehung überstreicht einen Zeitraum von zehn Jahren. Sie vermitteln so ein Bild von der Bewegung eines Denkens, das seinen Ausgangspunkt sowohl von der Erfahrung des Labors wie auch von der Textarbeit Jacques Derridas genommen hat. Seinem Andenken ist dieses Buch auch gewidmet.

Iterationen

Peter J. Beurton

Raphael Falk

Advances in molecular biological research in the latter half of the twentieth century have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? Philosophers, historians and working scientists re-evaluate the question in this volume, treating the gene as a focal point of interdisciplinary and international research. It will be of interest to professionals and students in the philosophy and history of science, genetics and molecular biology.

Historical and Epistemological Perspectives

The Concept of the Gene in Development and Evolution

Pablo Lorenzano

Eduardo Ortiz and Carlos Delfino Galles

History and Philosophy of Science and Technology is a component of Encyclopedia of Physical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The Theme on History and Philosophy of Science and Technology in four volumes covers several topics such as: Introduction to the Philosophy of Science; The Nature and Structure of Scientific Theories Natural Science; A Short History of Molecular Biology; The Structure of the Darwinian Argument In The Origin of Species; History of Measurement Theory; Episodes of XX Century Cosmology: A Historical Approach; Philosophy of Economics; Social Sciences: Historical And Philosophical Overview of Methods And Goals; Introduction to Ethics of Science and Technology; The Ethics of Science and Technology; The Control of Nature and the Origins of The Dichotomy Between Fact And Value; Science and Empires: The Geo-Epistemic Location of Knowledge; Science and Religion; Scientific Knowledge and Religious Knowledge - Significant Epistemological Reference Points; Thing Called Philosophy of Technology; Transitions from Function-Oriented To Effect-Oriented Technologies. Some Thought on the Nature of Modern Technology; Technical Agency and Sources of Technological Pessimism These four volumes are aimed at a broad spectrum of audiences: University and College Students, Educators and Research Personnel.

HISTORY AND PHILOSOPHY OF SCIENCE AND TECHNOLOGY -Volume III

David Hyder

This book is a collection of essays on Husserl's Crisis of European Sciences by leading philosophers of science and scholars of Husserl. Published and ignored under the Nazi dictatorship, Husserl's last work has never received the attention its author's prominence demands. In the Crisis, Husserl considers the gap that has grown between the "life-world" of everyday human experience and the world of mathematical science. He argues that the two have become disconnected because we misunderstand our own scientific past—we confuse mathematical idealities with concrete reality and thereby undermine the validity of our immediate experience. The philosopher's foundational work in the theory of intentionality is relevant to contemporary discussions of qualia, naive science, and the fact-value distinction. The scholars included in this volume consider Husserl's diagnosis of this "crisis" and his proposed solution. Topics addressed include Husserl's late philosophy, the relation between scientific and everyday objects and "worlds," the history of Greek and Galilean science, the philosophy of history, and Husserl's influence on Foucault.

Hans-Jörg Rheinberger

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