Henry O'Brien
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Henry O'Brien may refer to:Henry O'Brien, Lord Ibrackan, Irish nobleman and politician
Henry O'Brien, 5th Earl of Thomond (1588–1639), Irish peer
Henry O'Brien, 7th Earl of Thomond, Irish peer
Henry O'Brien, 8th Earl of Thomond (1688–1741), Irish peer and Member of Parliament
Henry O'Brien (1793–1866), Irish-born New South Wales politician
Henry O'Brien (classicist) (1808–1835), Irish classicist and author
Henry O'Brien (colonel), colonel of the 11th New York Volunteer Infantry Regiment killed during the New York draft riots
Henry O'Brien (cyclist) (1910–1973), American cyclist
Henry D. O'Brien (1842–-1902), Medal of Honor recipient from the American Civil War
Henry Joseph O'Brien (1896–1976), American prelate of the Roman Catholic Church
Henry L. O'Brien, American politician from New York
Henry X. O'Brien, American lawyer and judge