Aboul Ella Hassanien

Jerzy W. Grzymala-Busse

Guoyin Wang

Hong Yu

Ryszard Janicki

Tianrui Li

Hung Son Nguyen

This book constitutes the refereed proceedings of the 7th International Conference on Rough Sets and Knowledge Technology, RSKT 2012, held in Chengdu, China during August 2012, as one of the co-located conferences of the 2012 Joint Rough Set Symposium, JRS 2012. The 63 revised papers (including 42 regular and 21 short papers) were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on rough sets and its generalizations, rough sets in data and knowledge processing, knowledge technology, advances in granular computing (AGC 2012 workshop), decision-theoretic rough set model and applications (special session), intelligent decision making and granular computing (special session), rough set foundations (special session).

7th International Conference, RSKT 2012, Chengdu, China, August 17-20, 2012, Proceedings

Rough Sets and Knowledge Technology

Yu Hong is a Chinese artist who, influenced by the shifting social, cultural, and political landscape of her home country, seeks to portray the everyday experiences and challenges of women in China. This volume brings together images from Yu Hong's latest solo exhibition, 'Golden Horizon'.

Golden Horizon

Yu Hong

Yiyu Yao

Qinghua Hu

This book constitutes the refereed conference proceedings of the 15th International Conference on Rough Sets, Fuzzy Sets, Data Mining and Granular Computing, RSFDGrC 2015, held in Tianjin, China in November 2015 as one of the co-located conference of the 2015 Joint Rough Set Symposium, JRS 2015. The 44 papers were carefully reviewed and selected from 97 submissions. The papers in this volume cover topics such as rough sets: the experts speak; generalized rough sets; rough sets and graphs; rough and fuzzy hybridization; granular computing; data mining and machine learning; three-way decisions; IJCRS 2015 data challenge.

15th International Conference, RSFDGrC 2015, Tianjin, China, November 20-23, 2015, Proceedings

Rough Sets, Fuzzy Sets, Data Mining, and Granular Computing

Mu Yang

Annotation This text provides a focused analysis of the main Chinese industrial sectors through case studies, data analysis and review of new state-initiated policies.

China's Industrial Development in the 21st Century

Catalase-peroxidase (KatG) of Mycobacterium tuberculosis is a bifunctional heme enzyme that has been shown to play an important role in the activation of a first line drug, isoniazid (INH), used in the treatment of tuberculosis infection. Mutations in the katG gene have been found to be associated with INH resistance. The most commonly encountered mutation is the Ser315Thr point mutation. In this dissertation, the x-ray crystallographic structures of MtbKatG and the mutant enzyme KatG[S315T] are presented to explore the molecular basis of the INH activation and resistance. The structure is dimeric and contains a heme cofactor in each subunit of the dimer. The most important change in KatG[S315T] is due to the presence of the methyl group of the threonine 315 side chain, which is located at the narrowest part of the substrate channel. The protruding methyl group effectively constricts the accessibility to the heme by closing down the dimensions of the channel, constraining the substrate entrance. VirB11 of Brucella abortus is a hexameric ATPase that belongs to the type IV secretion system. The crystal structure of BaVirB11 was found to contain six molecules per asymmetric unit. The Walker A (P loop), His box, and Glu box from the C-terminal domain are located at the interface of the N- and C-terminal domain. A large conformational change was found in the linker region when compared with that of HP0525 structure, the VirB11 analogous from H. pylori. To elucidate the functional role of each domain, seven functional mutations were generated and used for biochemical studies. The GER motif and the linker region were found to be crucial for ATP hydrolysis activity of BaVirB11. Mutations in the GER motif (R101Q) and the linker region (R120E) of BaVirB11 completely abolish the ATP hydrolysis activity of the enzyme. The binding affinities of the two mutants to the ATP; however, are similar to that of the wild-type enzyme, indicating that mutation in the GER motif or the linker region has no effect on ATP binding.

Hong Yu

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