Alexander Zelikovsky

Ion Mandoiu

Presents algorithmic techniques for solving problems in bioinformatics, including applications that shed new light on molecular biology This book introduces algorithmic techniques in bioinformatics, emphasizing their application to solving novel problems in post-genomic molecular biology. Beginning with a thought-provoking discussion on the role of algorithms in twenty-first-century bioinformatics education, Bioinformatics Algorithms covers: General algorithmic techniques, including dynamic programming, graph-theoretical methods, hidden Markov models, the fast Fourier transform, seeding, and approximation algorithms Algorithms and tools for genome and sequence analysis, including formal and approximate models for gene clusters, advanced algorithms for non-overlapping local alignments and genome tilings, multiplex PCR primer set selection, and sequence/network motif finding Microarray design and analysis, including algorithms for microarray physical design, missing value imputation, and meta-analysis of gene expression data Algorithmic issues arising in the analysis of genetic variation across human population, including computational inference of haplotypes from genotype data and disease association search in case/control epidemiologic studies Algorithmic approaches in structural and systems biology, including topological and structural classification in biochemistry, and prediction of protein-protein and domain-domain interactions Each chapter begins with a self-contained introduction to a computational problem; continues with a brief review of the existing literature on the subject and an in-depth description of recent algorithmic and methodological developments; and concludes with a brief experimental study and a discussion of open research challenges. This clear and approachable presentation makes the book appropriate for researchers, practitioners, and graduate students alike.

Techniques and Applications

Bioinformatics Algorithms

Xuan Guo

Zhipeng Cai

Pavel Skums

Giri Narasimhan

This book constitutes the proceedings of the 16th International Symposium on Bioinformatics Research and Applications, ISBRA 2020, held in Moscow, Russia, in December 2020. The 23 full papers and 18 short papers presented in this book were carefully reviewed and selected from 131 submissions. They were organized in topical sections named: genome analysis; systems biology; computational proteomics; machine and deep learning; and data analysis and methodology.

16th International Symposium, ISBRA 2020, Moscow, Russia, December 1–4, 2020, Proceedings

Bioinformatics Research and Applications

Russell Schwartz

Jianxin Wang

Leonidas Bleris

This book constitutes the refereed proceedings of the International Symposium on Bioinformatics Research and Applications, ISBRA 2012, held in Dallas, Texas, USA, in May 2012. The 26 revised full papers presented together with five invited talks were carefully reviewed and selected from 66 submissions. The papers address issues on various aspects of bioinformatics and computational biology and their applications.

8th International Symposium, ISBRA 2012, Dallas, TX, USA, May 21-23, 2012. Proceedings

Yanqing Zhang

This book constitutes the refereed proceedings of the 5th International Symposium on Bioinformatics Research and Applications, ISBRA 2009, held in Fort Lauderdale, FL, USA, in May 2009. The 26 revised full papers presented together four invited papers were carefully reviewed and selected from a total of 55 submissions. The papers cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.

5th International Symposium, ISBRA 2009 Fort Lauderdale, FL, USA, May 13-16, 2009, Proceedings

Ion Mandoiu

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