Jianping Wang

王建平

The most comprehensive glossary to date of Hui Muslim terms and the first to fully match the Chinese term (stated in Chinese script and pinyin) to its Arabic or Persian counterpart (stated in Arabic script with Latin transcription).

中国伊斯兰教词汇表

Hua Zhang

Chronic administration of interferon-alpha (IFN-alpha, a type of I IFN) as an anti-viral or anti-cancer therapy in humans has frequently been found to result in severe psychiatric side effects, especially anxiety and depression. Type I IFN has also been implicated in neuropsychiatric dysfunction in systemic lupus erythematosus (SLE). Nevertheless, the role of type I IFN signaling in regulation of emotional behaviors is poorly defined because of limited access to the human brain. In this regard, behavioral impact of direct IFN-alpha treatment on animals remains highly controversial. The overall hypothesis tested is that the activation of type I IFN signaling directly contributes to emotional behavior dysfunction. First, behavioral evaluation in the mice with central nervous system (CNS)-targeted expression of IFN-alpha transgene revealed unaltered anxiety or depression profile. Second, using lupus-prone female NZBWF1 and NZB mice as animal models of human SLE, we demonstrated that (i) lupus-prone mice displayed anxiety-like behavior, and such behavioral dysfunction is correlated with their serum anti-nuclear autoantibody levels; (ii) repeated IFN-alpha treatment aggravated the anxiety-like behavior in lupus-prone NZBWF1 mice, but not that in the control NZW mice; and (iii) molecular dissection identified a significantly enhanced expression of interferon-stimulated genes in both brain and kidney in NZBWF1 mice compared with control NZW mice in response to repeated IFN-alpha treatment. Finally, ablation of type I IFN receptor did not reduce the anxiety-like behavior in autoimmune NZB female mice; however, such disruption of type I IFN signaling significantly attenuated the lupus-like kidney disease and splenomegaly in these mice. In conclusion, these findings indicated that up-regulated type I IFN signaling contribute to the behavioral dysfunction associated with autoimmune disease. However, activation of type I IFN signaling alone is not sufficient in inducing behavioral abnormality, suggesting that other factors are required for the development of IFN-alpha-triggered behavioral dysfunction in lupus-prone mice. The interactions between type I IFN and those uncharacterized contributing factors in the development of psychopathology following chronic INF-alpha treatment remain to be defined. Together, our studies demonstrate the complexity of type I IFN in behavioral regulation and provide new information regarding the CNS actions of type I IFN signaling.

Type I Interferon Signaling and Emotional Behavior Regulation

Stig Uggerhøj Andersen

Pascal Ratet

The legume-rhizobia symbiosis is a remarkable biological phenomena, which is critically important for sustainable agriculture. In the past decades, significant progress has been made to understand the mechanisms of the symbiotic processes. In this eBook, we present the most recent researches focusing on the molecular mechanisms of legume-rhizobia symbiosis including rhizobium characters, plant response to different types of bacteria, phytohormones involved in the symbiosis, SYM pathway signals, and R genes and specificity of rhizobia infection. This eBook will be a great reference book highlighting the research frontiers in legume-rhizobia symbiosis.

Jianping Wang

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