John Pollard

Leicestershire Institute for the Knitting and Allied Industries

Great Britain. Open Tech Unit

A Joint Project Between the Leicestershire Institute for the Knitting and Allied Industries and the Open Tech Unit. Yarns

Knitting Industry-project Update

Wolves and Werewolves

Birds in Greek Life and Myth

When Joseph Ratzinger chose the Papal name Benedict XVI he consciously bought into a legacy that has stretched over nearly 1500 years. From Bonosus in 575 to Bendict XV in 1914 the Benedictine legacy has been one of turmoil. Benedict XV is one of the least known Popes of the 20th century, but one of the most important. Elected in 1914 after the outbreak of the First World War he dedicated his Papacy to achieving peace throughout Europe. In August 1917 he offered a 'Peace Note' to the warring powers to bring about the cessation of hostilities, engaged in humanitarian activities and was instrumental is setting up the Save the Children Fund. Benedict sought to heal the wounds created by the 'Modernist crisis' of his predecessor, Pius X reign, but only after the end of World War I was he able to focus on matters within the church. Despite his innate conservatism he took up progressive positions on both the Easter Rite Churches and Catholicism's missionary outlook. He died relatively young yet his reign is one of the most important of any in the twentieth Century. This is the first biography of Pope Benedict XV published in English in over forty years. The author has made use of hitherto unavailable archival sources, particularly those of the Vatican previously unpublished private papers of his family.

The Unknown Pope and the Pursuit of Peace

Benedict XV

Helen of Troy

Best known for his efforts to end World War I, Benedict XV was the first contemporary pope to assume the role peacemaker, a role that has persisted in the papacy since. Although Benedict's 1917 Peace Note was rejected by officials, he went on to help establish Save the Children and to lead European efforts at humanitarian aid. His brief pontificate resulted in a positive reassessment of the Church's attitude towards colonialism and colonized peoples. Using previously unpublished correspondence and private papers from the Vatican archives, John Pollard has written the first biography on Benedict XV in almost half a century.

Benedict XV (1914-1922) and the Pursuit of Peace

The Unknown Pope

Nicola Curtin

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR. In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.

Targeting the DNA Damage Response for Anti-Cancer Therapy

John Pollard

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