World Health Organization

Joint FAO/WHO Expert Committee on Food Additives. Meeting

The toxicological monographs in this volume summarize the safety data on a number of food additives: asparaginase from Aspergillus niger expressed in A. niger, calcium lignosulfonate (40-65), ethyl lauroyl arginate, paprika extract, phospholipase C expressed in Pichia pastoris, phytosterols, phytostanols and their esters, polydimethylsiloxane and steviol glycosides. A monograph on the assessment of dietary exposure to sulfites is also included. Monographs on 10 groups of related flavoring agents evaluated by the Procedure for the Safety Evaluation of Flavouring Agents are also included. This volume also contains a monograph on incorporating the single portion exposure technique (SPET) into the Procedure for the Safety Evaluation of Flavouring Agents in the dietary exposure assessment of flavoring agents. This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.

Safety Evaluation of Certain Food Additives

This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventy-eight meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Geneva, Switzerland, from 5 to 14 November 2013. Four substances were evaluated for the first time--emamectin benzoate, gentian violet, lasalocid sodium and zilpaterol hydrochloride. Four additional substances were re-evaluated--derquantel, ivermectin, monepantel and recombinant bovine somatotrophins. The monographs provide information on chemical identity and properties of the compounds, pharmacokinetics and metabolism, residue depletion studies and analytical methods validated and used for the detection and quantification of the compounds. In addition, this document provides an overview of the pilot project to evaluate alternative approaches to estimate daily intakes of residues of veterinary drugs in foods and provides guidance on the extrapolation of MRLs to minor species and for the establishment of MRLs in honey. This publication and other documents produced by JECFA contain information that is useful to all those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods of animal origin.

Residue Evaluation of Certain Veterinary Drugs

Food and Agriculture Organization of the United Nations

This document is one of the three publications prepared by the forty-third session of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held in Geneva, November 1994, and dedicated exclusively to the evaluation of veterinary drug residues in food. The report of the meeting will be published in the WHO Technical Report Series, and the toxicological monographs as No. 34 in the WHO Food Additives Series. Residue monographs in this document provide information on chemical identity, properties, use, pharmacokinetics, metabolism, tissue residue depletion of, and analytical methods for substances indicated on the cover. This publication is meant for regulatory authorities, veterinary drug researchers and any other concerned persons who wish to gain information and insights into the needs and problems involved in establishing maximum limits for veterinary drug residues in food.

Monographs Prepared by the Forty-third Meeting of the Joint FAO/WHO Expert Committee on Food Additives, Geneva, 15-24 November 1994

Residues of Some Veterinary Drugs in Animals and Foods

Safety Evaluation of Certain Contaminants in Food

The toxicological monographs in this volume summarize the safety data on a number of food additives: branching glycosyltransferase from Rhodothermus obamensis expressed in Bacillus subtilis, cassia gum, ferrous ammonium phosphate, glycerol ester of gum rosin, glycerol ester of tall oil rosin, lycopene from all sources, octenyl succinic acid modified gum arabic, sodium hydrogen sulfate and sucrose oligoesters type I and type II. A monograph on the assessment of dietary exposure to cyclamic acid and its salts is also included. This volume and others in the WHO Food Additives Seriescontain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.

Joint FAO/WHO Expert Committee on Food Additives

Specifications for Identity and Purity of Buffering Agents, Salts, Emulsifiers, Thickening Agents, Stabilizers, Flavouring Agents, Food Colours, Sweetening Agents, and Miscellaneous Food Additives

This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventy-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Rome, Italy form 8 to 17 November 2011. Four substances were evaluated for the first time for the animal species concerned -- amoxicillin, apramycin, derquantel and monepantel. Three subtances were reassessed, monensin, narasin and triclabendzole. This publication and other documents produced by JECFA contain information that is useful to those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods of animal origins.

Joint FAO/WHO Expert Committee on Food Additives, 75th Meeting, Rome, Italy, 8-17 November 2011

The monographs in this volume summarize data on the veterinary drug residues that were evaluated toxicologically by the Committee, which included three antimicrobial agents (cefuroxime, flumequine and pirlimycin), two insecticides (cyhalothrin, and cypermethrin and alpha-cypermethrin) and one production aid (ractopamine). The Committee also evaluated the safety of low levels of the antimicrobial agent chloramphenicol in animal products. This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories, and universities.

Toxicological Evaluation of Certain Veterinary Drug Residues in Food

This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavoring agents with a view to recommending acceptable daily intakes (ADIs) and to preparing specifications for identity and purity. The Committee also evaluated the risk posed by two food contaminants with the aim of advising on risk management options for the purpose of public health protection. Annexed to the report are tables summarizing the Committee's recommendations for intakes and toxicological evaluations of the food additives and contaminants considered.

Sixty-eighth Report of the Joint FAO/WHO Expert Committee on Food Additives

Evaluation of Certain Food Additives and Contaminants

This volume contains monographs prepared at the fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Five mycotoxins or groups of mycotoxins that contaminate food commodities were evaluated at the meeting: aflatoxin M1, fumonisins B1, B2, and B3, ochratoxin A, deoxynivalenol, and T -2 and HT -2 toxins. The monographs in this volume summarize the data that were reviewed on these contaminants, including information on metabolism and toxicity, epidemiology, analytical methods for their measurement in food commodities, sampling protocols, effects of processing, levels and patterns of contamination of food commodities, food consumption, and prevention and control. Based upon this information the Committee assessed the risks associated with intake of these mycotoxins.

Safety Evaluation of Certain Mycotoxins in Food

This document is one of the three publications prepared by the forty-eighth session of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held in Geneva, February 1997, and dedicated exclusively to the evaluation of, veterinary drug residues in food. The report of the meeting will be published in the WHO Technical Report Series, and the toxicological monographs as No. 39 in the WHO Food Additives Series. Residue monographs in this document provide information on chemical identity, properties, use, pharmacokinetics, metabolism, tissue residue depletion of, and analytical methods for substances indicated on the cover. This publication is meant for regulatory authorities, veterinary drug researchers and any other concerned persons who wish to gain information and insights into the needs and problems involved in establishing maximum limits for veterinary drug residues in food.

Monographs

Monographs Prepared by the Thirty-Fourth Meeting of the Joint FAO/WHO Expert Committee on Food Additives, Geneva, 30 January-8 February 1989

This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives and a food contaminant with a view to concluding as to safety concerns and to preparing specifications for identity and purity. The first part of the report contains a general discussion of the principles governing the toxicological evaluation of and assessment of dietary exposure to food additives. A summary follows of the Committee's evaluations of technical toxicological and dietary exposure data for seven food additives (advantame; glucoamylase from Trichoderma reesei expressed in Trichoderma reesei; glycerol ester of gum rosin; glycerol ester of tall oil rosin; glycerol ester of wood rosin; nisin; and octenyl succinic acid modified gum arabic) and an assessment of dietary exposure to cadmium from cocoa and cocoa products. Specifications for the following food additives were revised: annatto extracts (solvent-extracted bixin and solvent-extracted norbixin); Benzoe tonkinensis; food additives containing aluminium and/or silicon; mineral oil (medium viscosity); modified starches; paprika extract; phosphates (analytical methods for the determination of phosphorus and revision of specifications); 3-phytase from Aspergillus niger expressed in Aspergillus niger; potassium aluminium silicate; and potassium aluminium silicate-based pearlescent pigments. Annexed to the report are tables summarizing the Committee's recommendations for dietary exposures to and toxicological evaluations of the food additives and contaminant considered.

Thirty-seventh Report of the Joint FAO/WHO Expert Committee on Food Additives

On cover: Deltamethrin, Dihydrostreptomycin, Doramectin, Estradiol-17B, Neomycin, Phoxim, Porcine somatotropins, Progesterone, Streptomycin, Testosterone, Thiamphenicol

International Program on Chemical Safety

The toxicological monograph's in this volume summarize the safety data on a number of food additives: Beeswax Candelilla wax Quillaia extract Type 1 and 2 Phospholipase from fusarium venenatum expressed in Aspergillus oryzae Calcium L-5 methyltetrahydrofolate (L-5_MTHF) and Pulllulan (Pullulan P1-20). Monograph's on seven groups of related flavouring agents evaluated by the Procedure for the Safety Evaluation of Flavouring Agents are also included.

Joint FAO/WHO Expert Committee on Food Additives. Meeting

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