Jun Sun

Yinglin Xia

This unique book addresses the bioinformatic and statistical modelling and also the analysis of microbiome data using cutting-edge QIIME 2 and R software. It covers core analysis topics in both bioinformatics and statistics, which provides a complete workflow for microbiome data analysis: from raw sequencing reads to community analysis and statistical hypothesis testing. It includes real-world data from the authors’ research and from the public domain, and discusses the implementation of QIIME 2 and R for data analysis step-by-step. The data as well as QIIME 2 and R computer programs are publicly available, allowing readers to replicate the model development and data analysis presented in each chapter so that these new methods can be readily applied in their own research. Bioinformatic and Statistical Analysis of Microbiome Data is an ideal book for advanced graduate students and researchers in the clinical, biomedical, agricultural, and environmental fields, as well as those studying bioinformatics, statistics, and big data analysis.

From Raw Sequences to Advanced Modeling with QIIME 2 and R

Bioinformatic and Statistical Analysis of Microbiome Data

Yang Liu

Grigoris Antoniou

Wei Hu

Jin Song Dong

Yuan-Fang Li

Zhe Wang

This book constitutes the thoroughly refereed proceedings of the 6th Joint International Semantic Technology Conference, JIST 2016, held in Singapore, Singapore, in November 2016. The main topics of JIST 2016 include among others ontology and reasoning; linked data; knowledge graph. The JIST 2016 conference consists of two keynotes, a main technical track, including (full and short papers) from the research and the in-use tracks, a Poster and Demo session, a workshop and two tutorials. The 16 full and 8 short papers presented were carefully reviewed and selected from 34 submissions. The papers cover the following topics: ontology and data management; linked data; information retrieval and knowledge discovery; RDF and query; knowledge graph; application of semantic technologies.

6th Joint International Conference, JIST 2016, Singapore, Singapore, November 2-4, 2016, Revised Selected Papers

Semantic Technology

This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

Evidence, Mechanisms, and Implications

Inflammation, Infection, and Microbiome in Cancers

Pradeep K. Dudeja

Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.

Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases

Ding-Geng Chen

This unique book addresses the statistical modelling and analysis of microbiome data using cutting-edge R software. It includes real-world data from the authors’ research and from the public domain, and discusses the implementation of R for data analysis step by step. The data and R computer programs are publicly available, allowing readers to replicate the model development and data analysis presented in each chapter, so that these new methods can be readily applied in their own research. The book also discusses recent developments in statistical modelling and data analysis in microbiome research, as well as the latest advances in next-generation sequencing and big data in methodological development and applications. This timely book will greatly benefit all readers involved in microbiome, ecology and microarray data analyses, as well as other fields of research.

Statistical Analysis of Microbiome Data with R

Cliff Jones

Pekka Pihlajasaari

This book constitutes the refereed proceedings of the 19th International Symposium on Formal Methods, FM 2014, held in Singapore, May 2014. The 45 papers presented together with 3 invited talks were carefully reviewed and selected from 150 submissions. The focus of the papers is on the following topics: Interdisciplinary Formal Methods, Practical Applications of Formal Methods in Industrial and Research Settings, Experimental Validation of Tools and Methods as well as Construction and Evolution of Formal Methods Tools.

Jun Sun

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