Learn-Han Lee

Om V. Singh

Nurul-Syakima Ab Mutalib

Marta López

A question raised by many individuals today – “How Safe is Our Food Consumed Today?” Food safety has become a hot topic and an important public issue due to the increasingly widespread nature of foodborne illnesses in both developed and developing countries. As food is biological in nature and supplies consumers with nutrients, it is also equally capable of supporting the growth of microorganisms from the environmental sources. A precise method of monitoring and detecting of foodborne pathogens including Salmonella sp., Vibrio sp., Listeria monocytogenes, Campylobacter and Norovirus is needed to prevent and control human foodborne infections. Clinical treatments of infection caused by foodborne pathogens are becoming tougher with the increase number of multidrug resistant pathogens in the environment. This situation creates a huge healthcare burden – e.g. prolonged treatment for infections, decrease in the efficacy of antibiotic, delay in treatment due to unavailability of new antibiotics, and increased number of deaths. As such, continuous investigation of the foodborne pathogens is needed to pave the way for a deeper understanding on the foodborne diseases and to improve disease prevention, management and treatments.

Food Safety and Foodborne Pathogen – A Global Perspective on the Diversity, Combating Multidrug Resistance and Management

Kok-Gan Chan

Bey-Hing Goh

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Actinobacteria: Prolific Producers of Bioactive Metabolites

Sunny Hei Wong

Siok-Fong Chin

Vishal Singh

Human Microbiome: Symbiosis to Pathogenesis

Jem Stach

Elizabeth M. H. Wellington

There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers. Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar.

The Search for Biological Active Agent(s) From Actinobacteria, 2nd Edition

Pendru Raghunath

Vibrio are Gram-negative bacteria that naturally inhabit riverine, estuarine and marine aquatic environments. Some Vibrio are known to be capable of causing gastroenteritis, wound infections, cholera and fatal septicemia in severe cases. Over the past decades, research on Vibrio has increased and has caused a great development in our knowledge of these pathogens. Focus of this research includes the discovery of emerging epidemic clones, the traits of new strains, and the occurrence of multidrug resistant strains in the ecology. Moreover, improved understandings of the prevalence, pathogenesis and evolution of Vibrio have revealed the significant role of these pathogens in enhancing disease transmission. The complete genomic sequences of Vibrio have been determined in providing a rich set of data illuminating the metabolic versatility of the species. This book is dedicated to improving our knowledge and understanding, not solely focusing into the prevalence, detection, pathogenesis, virulence, pandemic clones and multidrug resistance, but also looking at the management of the multidrug resistance through different strategies such as non-antibiotic resistant strategies that involved the application of knowledge in bacteriophages.

Vibrionaceae Diversity, Multidrug Resistant and Management

Learn-Han Lee

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