Mark M. Davis

Joel Buxbaum

Animal models of some autoimmune diseases have indicated restricted T-cell receptor use and have suggested therapies based on those data. Patients with naturally occurring diseases have not shown a consistent picture of receptor utilisation. This volume discusses the spectrum of T-cell receptor use in human disease, the relationship between the human and animal findings, and the biological and therapeutic implications of the former.

T-cell Receptor Use in Human Autoimmune Diseases

Huang Huang

This volume provides a comprehensive compilation of protocols in T cell repertoire analysis, from the leading experts in the field, representing both well-established methods and cutting-edge advances. Chapters broadly cover the emerging new T cell subsets, sequencing technologies for capturing TCR repertoire, and computational tools for analyzing an ever-growing TCR repertoire, with a particular focus on how to link the sequence with TCR antigen specificity. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, T-Cell Repertoire Characterization aims to be a useful practical guide to researches to help further their study in this field.

T-Cell Repertoire Characterization

Davis, Fundamentals of Operations Management,fits the one semester course at either the undergrad or MBA market. The 1st Canadian edition addresses the increasing trend toward briefer, less quantitative and more managerial on issues that confront managers today and does so within a Canadian and global perspective. Davis also serves customers in search of a brief conceptual overview to support their own lecture notes, additional readings and/or case material.

Mark M. Davis

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