David A. Sinclair

Matthew D. LaPlante

A NEW YORK TIMES BESTSELLER A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Why We Age—and Why We Don't Have To

Lifespan

Welcome to the biggest, fastest, deadliest science book you'll ever read. The world's largest land mammal could help us end cancer. The fastest bird is showing us how to solve a century-old engineering mystery. The oldest tree is giving us insights into climate change. The loudest whale is offering clues about the impact of solar storms. For a long time, scientists ignored superlative life forms as outliers. Increasingly, though, researchers are coming to see great value in studying plants and animals that exist on the outermost edges of the bell curve. As it turns out, there’s a lot of value in paying close attention to the “oddballs” nature has to offer. Go for a swim with a ghost shark, the slowest-evolving creature known to humankind, which is teaching us new ways to think about immunity. Get to know the axolotl, which has the longest-known genome and may hold the secret to cellular regeneration. Learn about Monorhaphis chuni, the oldest discovered animal, which is providing insights into the connection between our terrestrial and aquatic worlds. Superlative is the story of extreme evolution, and what we can learn from it about ourselves, our planet, and the cosmos. It's a tale of crazy-fast cheetahs and super-strong beetles, of microbacteria and enormous plants, of whip-smart dolphins and killer snakes. This book will inspire you to change the way you think about the world and your relationship to everything in it.

The Biology of Extremes

Superlative

¿Y si envejecer fuera una enfermedad y fuese tratable como tal? El libro escrito por un aclamado científico de la facultad de Medicina de Harvard y una de las personas más influyentes de según Time, que cambiará paradigmas sobre el envejecimiento. Que envejecer es inevitable es una verdad aparentemente innegable. pero, ¿qué pasaría si todo lo que se nos ha dicho hasta ahora sobre el envejecimiento resultase incierto?, ¿qué sucedería si pudiéramos elegir nuestra esperanza de vida? En este libro innovador y asombroso, el Dr. David Sinclair, autoridad mundial y líder en genética y longevidad, revela una nueva y audaz teoría. Como él explica, el envejecimiento es una enfermedad y es una enfermedad tratable. Experimentos recientes en la reprogramación genética sugieren que, en un futuro cercano, no solo podremos sentirnos más jóvenes, sino serlo. Mediante estas páginas, el Dr. Sinclair nos invita al proceso de descubrimiento científico y revela algunas tecnologías emergentes y algunos cambios simples en el estilo de vida que nos ayudarán a sentirnos más jóvenes y a estar más saludables por más tiempo como el ayuno intermitente, la exposición al frío, hacer ejercicio con la intensidad adecuada y comer menos carne. Alarga tu esperanza de vida cambiará para siempre nuestra idea sobre por qué envejecemos y qué podemos hacer al respecto. El doctor David Sinclair es profesor de genética en la Harvard Medical School y ha sido nombrado por la revista Time como una de las 100 personas más influyentes. Su trabajo ha aparecido ampliamente en los medios de comunicación y ha fundado y codirigido nueve compañías de biotecnología desde 2005.

Matthew D. LaPlante

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