Megan O'Brien

The Ride Series

Cole

Axel

Claim

Gunner (Ride

Max (Ride

Ryker

From the author of the best-selling Ride Series comes the new Talon Security series!****I didn't realize I was falling, not until my heart was lost in love with him.After years of close friendship with former Marine and security specialist, Sid Masters, Samantha McAllister finds herself grappling with feelings far beyond friendship. After a line is crossed, Sam's heart is broken in the process.When Sam gets caught up in a web of deceit and violence that brings the Russian mafia to her door, Sid will stop at nothing to protect her.Samantha belongs with Sid; she just doesn't know it yet. He's determined to show her.With the men of Talon at his back, Sid fights to protect his girl and to reclaim her heart.This is the story of Sam and Sid.Book One of the Talon Security series, can be read as a stand alone.* Due to strong language and sexual content, this book is not intended for readers under the age of 18.

Crave

Cash (Ride

Maddox (Ride

Grace

Ashleigh R. Poh

David Chisanga

Hong He

David Baloyan

Jasmin Traichel

Christine Dijkstra

Michaël Chopin

Stephen L. Nutt

Lachlan Whitehead

Louis Boon

Ashleigh Parkin

Clifford A. Lowell

Marina Pajic

Wei. Q. Shi

Mehrdad Nikfarjam

Matthias Ernst

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a low 5-year survival rate and is associated with poor response to therapy. Elevated expression of the myeloid-specific hematopoietic cell kinase (HCK) is observed in PDAC and correlates with reduced patient survival. To determine whether aberrant HCK signaling in myeloid cells is involved in PDAC growth and metastasis, we established orthotopic and intrasplenic PDAC tumors in wild-type and HCK knockout mice. Genetic ablation of HCK impaired PDAC growth and metastasis by inducing an immune-stimulatory endotype in myeloid cells, which in turn reduced the desmoplastic microenvironment and enhanced cytotoxic effector cell infiltration. Consequently, genetic ablation or therapeutic inhibition of HCK minimized metastatic spread, enhanced the efficacy of chemotherapy, and overcame resistance to anti-PD1, anti-CTLA4, or stimulatory anti-CD40 immunotherapy. Our results provide strong rationale for HCK to be developed as a therapeutic target to improve the response of PDAC to chemo- and immunotherapy

Inhibition of HCK in Myeloid Cells Restricts Pancreatic Tumor Growth and Metastasis

Megan O'Brien

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