Michael Potter

Fire!

Fritz Melchers

The 12th Workshop on ""Mechanisms in B-Cell Neoplasia"" continues this series of meetings on intriguing new developments in human and experimental B-cell tumors. The integration of knowledge from basic B-cell biology to the clinical problems of multiple myelomas, follicular lymphoma, mantle cell lymphoma and B-CLL present the challenges that were discussed in the meeting. The discussion focusses on: - Cellular components of the "myeloma clone" - Genomic instability in B-cells and B-cell tumors - The CD5 antigen and B1 cells - Regulation of cell cycle and apoptosis - Role of IL-6, BCL-2, BCL-1, myc in B-cell development

Mechanisms in B-Cell Neoplasia 1994

Beverly Mock

The development of innovative molecular techniques such as pulse-field gel electro phoresis, cDNA subtraction libraries and chromosome hopping libraries coupled with the increasing popularity in the prospect of sequencing mammalian genomes, has triggered a resurgence of interest in finding and characterizing genes that playa role in modifying immune processes and diseases. Genetically defined strains of mice (e. g. , inbred strains and recently derived stocks of wild mice) provide ideal models for examining the genetic control of diseases as a result of their syntenic relationship with man in genetic composition as well as linkage conserva tion. Due to the relative ease of producing a specific genotype via appropriate breeding schedules, murine models may provide the only hope for unravelling those complex disease processes under mUltigenic control. This issue of CTMI is a collection of papers on the characterization and mapping of genes involved in mutations and dysregulated immune responses which produce disease phenotypes. These papers were presented at a workshop which was devoted to examining reverse genetic approaches at localizing, cloning and characterizing genes involved in a variety of developmental, autoimmune, neoplastic and infectious disease processes. In the first of three sections, a series of papers outline the most currently used methods of mapping and isolating genes whose products are unknown. The papers, following, are devoted to specific gene systems whose dysregulation is likely to produce mutant or disease phenotypes.

Genetics of Immunological Diseases

Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD,USA,March 24–26,1986

Mechanisms in B-Cell Neoplasia

Workshops on the mechanisms of B cell neoplasia have been organized alternatively in Bethesda and Basel since 1983. Prog ress in our understanding of the development and responses of B lymphocytes is presented and discussed with the aim and hope to understand what might go wrong when B lymphocytes are transformed into malignant cells. Such knowledge might lead to better diagnosis, prevention and even cure of these terri ble diseases. The presentations at the Bethesda workshops are published as papers in volumes of Current Topics in Microbiol ogy and Immunology, while the presentations and discussions in Basel were transcribed and published in Editions Roche. For the first time, a Basel workshop (held 4th-6th October 1998) that has been recorded and, in part, transcribed is being published as papers and discussions within Current Topics. This volume is the latest of a long series which documents the excitements of ground-breaking discoveries as well as the frustrations of our inability to fully understand the mechanisms leading to B cell neoplasia. The papers at the workshop are presented when possible in the sequence in which they were given. However, to facilitate the organization and reading of the book and to highlight gen eral topics and themes, the papers are organized into five sec tions: I B Cell and Plasma Cell Development II Chemokines and Chemokine Receptors III Chromosomal Translocations, DNA Rearrangements and Somatic Hypermutations IV Biology of Lymphomagenesis, B-CLL, Autoimmunity V Myeloma, Plasmacytomas and Related Subjects.

Proceedings of the Workshop held at the Basel Institute for Immunology 4th–6th October 1998

Mechanisms of B Cell Neoplasia 1998

How do we account for the truth of arithmetic? And if it does not depend for its truth on the way the world is, what constrains the world to conform to arithmetic? This text examines the progress made towards answering these questions.

Philosophies of Arithmetic from Kant to Carnap

Reason's Nearest Kin

Tom Ricketts

Gottlob Frege (1848–1925) was unquestionably one of the most important philosophers of all time. He trained as a mathematician, and his work in philosophy started as an attempt to provide an explanation of the truths of arithmetic, but in the course of this attempt he not only founded modern logic but also had to address fundamental questions in the philosophy of language and philosophical logic. Frege is generally seen (along with Russell and Wittgenstein) as one of the fathers of the analytic method, which dominated philosophy in English-speaking countries for most of the twentieth century. His work is studied today not just for its historical importance but also because many of his ideas are still seen as relevant to current debates in the philosophies of logic, language, mathematics and the mind. The Cambridge Companion to Frege provides a route into this lively area of research.

The Cambridge Companion to Frege

Peter Sullivan

This volume of newly written chapters on the history and interpretation of Wittgenstein's Tractatus represents a significant step beyond the polemical debate between broad interpretive approaches that has recently characterized the field. It makes a strong case that close investigation, both biographical and textual, into the composition of the Tractatus, and into the various influences on it, still has much to yield in revealing the complexityand fertility of Wittgenstein's early thought. The themes explored range across the breadth of Wittgenstein's book, and include his accounts of ethics and aesthetics, as well as issues in metaphysics and the philosophyof mind, and aspects of the logical framework of his account of representation. By approaching Wittgenstein's thought through the various first-level issues that give rise to it, rather than from entrenched schematic positions, the contributors demonstrate the possibility of a more inclusive, constructive and fruitful mode of engagement with Wittgenstein's text and with each other.

History and Interpretation

Wittgenstein's Tractatus

Joseph H. Nadeau

Michael P. Cancro

The present volume of "Current Topics in Microbiology and Immunology" is a series of papers on subjects that are relevant to the growing use of 'wild mice' in immunological, microbiological and genetical research. 'Wild mice' is a jargonistic term that is used chiefly in the laboratory to refer to the naturally living forms of house mice (Mus musculus) and also other species closely related to M. musculus. This group of species is designated by systematists as the genus Mus. Immunologists began 20 years ago to study the polymorphisms of 1mmunoglobulins and major histocompatibility complex antigens in wild mice. An extrordinary extension of the highly polymorphic array of phenotypes known in inbred mice was encountered. Breeding stocks of wild mice were brought into the laboratory. This included not only M. musculus but a)so many of the available species in the genus Mus-from Southeast Asia ~nd Europe. This availability led to other comparisons of 'wild' and inbred mice and the discovery of other new and interesting phenotypes and genotypes. It became apparent that inbred strains of mice provided only a limited window for viewing the genetic diversity of Mus musculus.

The Wild Mouse in Immunology

Workshop at the Basel Institute for Immunology, March 29-31, 1989

Mechanisms of B Cell Neoplasia 1989

This volume of newly written chapters on the history and interpretation of Wittgenstein's Tractatus represents a significant step beyond the polemical debate between broad interpretive approaches that has recently characterized the field. Some of the contributors might count their approach as 'new' or 'resolute', while others are more 'traditional', but all are here concerned primarily with understanding in detail the structure of argument that Wittgenstein presents within the Tractatus, rather than with its final self-renunciation, or with the character of the understanding that renunciation might leave behind. The volume makes a strong case that close investigation, both biographical and textual, into the composition of the Tractatus, and into the various influences on it, still has much to yield in revealing the complexity and fertility of Wittgenstein's early thought. Amongst these influences Kant and Kierkegaard are considered alongside Wittgenstein's immediate predecessors in the analytic tradition. The themes explored range across the breadth of Wittgenstein's book, and include his accounts of ethics and aesthetics, as well as issues in metaphysics and the philosophy of mind, and aspects of the logical framework of his account of representation. The contrast of saying and showing, and Wittgenstein's attitude to the inexpressible, is of central importance to many of the contributions. By approaching this concern through the various first-level issues that give rise to it, rather than from entrenched schematic positions, the contributors demonstrate the possibility of a more inclusive, constructive and fruitful mode of engagement with Wittgenstein's text and with each other.

The papers in this book were presented at the 14th Mechanisms in B-cell Neoplasia meeting that was held in Bethesda, Maryland October 21-23, 1996. In 1995 the organizers decided that the format of the meeting would be changed and that specific topics relevant to B-cell neoplasia would be discussed. This year's topic is on the c-myc oncogene in B-cell neoplasia which has been discussed in virtually every previous meeting. Some of the presentations announced for the first time dramatic advances in our understanding of c-myc and because this subject has become highly complex it was thought that devoting the whole meeting to this theme would be appropriate. The book, therefore, repre sents a review of many aspects of the myc problem but by no means is truly comprehensive. In a recent Medline search there were 8,505 references to myc, fully illustrating the magnitude of the interest and depth of this field. The organizers of the meeting have each contributed review chapters that summarize different aspects of the meeting. We thank the National Cancer Institute for sponsoring this workshop and the staff of Cygnus, Inc. , for their outstanding organizational assistance. The organizers are most grateful to Vickie Rogers for assembling the book and dealing with the edi torialization of the manuscripts. MICHAEL POlTER FRITZ MELCHERS Table of Contents M. POlTER and K. B. MARCU The c-myc Story: Where We've Been, Where We Seem to be Going. With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . I F.

14th Workshop on Mechanisms in B-Cell Neoplasia

C-Myc in B-Cell Neoplasia

How do we account for the truth of arithmetic? And if it does not depend for its truth on the way the world is, what constrains the world to conform to arithmetic? Reason's Nearest Kin is a critical examination of the astonishing progress made towards answering these questions from the late nineteenth to the mid-twentieth century. In the space of fifty years Frege, Dedekind, Russell, Wittgenstein, Ramsey, Hilbert, and Carnap developed accounts of the content of arithmeticthat were brilliantly original both technically and philosophically. Michael Potter's innovative study presents them all as finding that content in various aspects of the complex linkage between experience, language, thought, and the world. Potter's reading places them all in Kant's shadow since it was hisattempt to ground arithmetic in the spatio-temporal structure of reality that they were reacting against; but it places us in Gödel's shadow since his incompleteness theorems supply us with a measure of the richness of the content they were trying to explain. This stimulating reassessment of some of the classic texts in the philosophy of mathematics reveals many unexpected connections and illuminating comparisons, and offers a wealth of ideas for future work in the subject.

This is the first book-length study of Wittgenstein's first philosophical work, The Notes on Logic . Since Wittgenstein is one of the most important figures in the history of philosophy, and one of the few who attracts the interest of non-philosophers, the book is likely to be of unusually wide interest. Using a challenging blend of biography and philosophy, it draws new conclusions about the nature of the Notes , about the genesis of theTractatus (which draws on material from them), and about Wittgenstein's highly individualistic working methods.

Michael Potter

About

Books

Join the club