Mike S. Lee

Wenkui Li

An informative and comprehensive book on the applications andtechniques of dried blood spot sampling Dried blood spot (DBS) sampling involves the collection of asmall volume of blood, via a simple prick or other means, from astudy subject onto a cellulose or polymer paper card, which isfollowed by drying and transfer to the laboratory for analysis. Formany years, this method of blood sample collection has beenextensively utilized in some important areas of human healthcare(for example, newborn screening for inherited metabolic disordersand HIV-related epidemiological studies). Because of its advantagesover conventional blood, plasma, or serum sample collection, DBSsampling has been valued by the pharmaceutical industry in drugresearch and development. Dried Blood Spots: Applications and Techniques featurescontributions from an international team of leading scientists inthe field. Their contributions present a unique resource on thehistory, principles, procedures, methodologies, applications, andemerging technologies related to DBS. Presented in three parts, the book thoroughly examines: Applications of DBS sampling and associated procedures andmethodologies in various human healthcare studies Applications and perspectives of DBS sampling in drug researchand development, and therapeutic drug monitoring New technologies and emerging applications related to DBSsampling and analysis Dried Blood Spots: Applications and Techniques is avaluable working guide for researchers, professionals, and studentsin healthcare, medical science, diagnostics, clinical chemistry,and pharmaceuticals, etc.

Applications and Techniques

Dried Blood Spots

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

Integrated Strategies for Drug Discovery Using Mass Spectrometry

Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

Mass Spectrometry Handbook

Mingshe Zhu

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

Mike S. Lee

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