Min Li

Ovidiu Daescu

Zhipeng Cai

This book constitutes the proceedings of the 13th International Symposium on Bioinformatics Research and Applications, ISBRA 2017, held in Honolulu, HI, USA, in May/June 2017. The 27 full papers presented together with 18 short papers and 24 invited abstracts were carefully reviewed and selected from 131 submissions. They cover topics such as: biomarker discovery; biomedical databases and data integration; biomedical text mining and ortologies; biomolecular imaging; comparative genomics; computational genetic epidemiology; computational proteomics; data mining and visualization; gene expression analysis; genome analysis; high-performance bio-computing; metagenomics; molecular evolution; molecular modelling and simulation; next-generation sequencing data analysis; pattern discovery and classification; population genetics; software tools and applications; structural biology; and systems biology.

13th International Symposium, ISBRA 2017, Honolulu, HI, USA, May 29 – June 2, 2017, Proceedings

Bioinformatics Research and Applications

Yi Pan

Jianxin Wang

Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics An in-depth look at the latest research, methods, and applications in the field of protein bioinformatics This book presents the latest developments in protein bioinformatics, introducing for the first time cutting-edge research results alongside novel algorithmic and AI methods for the analysis of protein data. In one complete, self-contained volume, Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics addresses key challenges facing both computer scientists and biologists, arming readers with tools and techniques for analyzing and interpreting protein data and solving a variety of biological problems. Featuring a collection of authoritative articles by leaders in the field, this work focuses on the analysis of protein sequences, structures, and interaction networks using both traditional algorithms and AI methods. It also examines, in great detail, data preparation, simulation, experiments, evaluation methods, and applications. Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics: Highlights protein analysis applications such as protein-related drug activity comparison Incorporates salient case studies illustrating how to apply the methods outlined in the book Tackles the complex relationship between proteins from a systems biology point of view Relates the topic to other emerging technologies such as data mining and visualization Includes many tables and illustrations demonstrating concepts and performance figures Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics is an essential reference for bioinformatics specialists in research and industry, and for anyone wishing to better understand the rich field of protein bioinformatics.

Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics

Xianhua Song

Zeguang Lu

Hongzhi Wang

Beiji Zou

Wei Xie

This two volume set (CCIS 727 and 728) constitutes the refereed proceedings of the Third International Conference of Pioneering Computer Scientists, Engineers and Educators, ICPCSEE 2017 (originally ICYCSEE) held in Changsha, China, in September 2017. The 112 revised full papers presented in these two volumes were carefully reviewed and selected from 987 submissions. The papers cover a wide range of topics related to Basic Theory and Techniques for Data Science including Mathematical Issues in Data Science, Computational Theory for Data Science, Big Data Management and Applications, Data Quality and Data Preparation, Evaluation and Measurement in Data Science, Data Visualization, Big Data Mining and Knowledge Management, Infrastructure for Data Science, Machine Learning for Data Science, Data Security and Privacy, Applications of Data Science, Case Study of Data Science, Multimedia Data Management and Analysis, Data-driven Scientific Research, Data-driven Bioinformatics, Data-driven Healthcare, Data-driven Management, Data-driven eGovernment, Data-driven Smart City/Planet, Data Marketing and Economics, Social Media and Recommendation Systems, Data-driven Security, Data-driven Business Model Innovation, Social and/or organizational impacts of Data Science.

Third International Conference of Pioneering Computer Scientists, Engineers and Educators, ICPCSEE 2017, Changsha, China, September 22–24, 2017, Proceedings, Part I

Data Science

Du Feng

Yusong Guo

Laura Lackner

Liang Ge

Marta Giacomello

Nuno Raimundo

Timothy Wai

Keeping in Touch: The Role of Organelle Dynamics and Contacts in Health and Disease

A thought-provoking book on archaeology of power, knowledge, social memory, and the emergence of classical tradition in early China.

Social Memory and State Formation in Early China

Pavel Skums

This book constitutes the proceedings of the 15th International Symposium on Bioinformatics Research and Applications, ISBRA 2019, held in Barcelona, Spain, in June 2019. The 22 full papers presented in this book were carefully reviewed and selected from 95 submissions. They were organized in topical sections named: genome analysis; systems biology; computational proteomics; machine and deep learning; and data analysis and methodology.

15th International Symposium, ISBRA 2019, Barcelona, Spain, June 3–6, 2019, Proceedings

The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.

Organic Chemistry of Drug Degradation

Min Li

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