Nick Lane

One of the deepest, most illuminating books about the history of life to have been published in recent years. The Economist"

Energy, Evolution, and the Origins of Complex Life

The Vital Question

Nick Lane expertly reconstructs the history of life by describing the ten greatest inventions of evolution (including DNA, photosynthesis, sex, and sight), based on their historical impact, role in organisms today, and relevance to current controversies.

The Ten Great Inventions of Evolution

Life Ascending

Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. 'An extraordinary account of groundbreaking modern science... The book abounds with interesting and important ideas.' Mark Ridley, Department of Zoology, University of Oxford

Mitochondria and the Meaning of Life

Power, Sex, Suicide

Oxygen takes the reader on an enthralling journey, as gripping as a thriller, as it unravels the unexpected ways in which oxygen spurred the evolution of life and death. The book explains far more than the size of ancient insects: it shows how oxygen underpins the origin of biological complexity, the birth of photosynthesis, the sudden evolution of animals, the need for two sexes, the accelerated ageing of cloned animals like Dolly the sheep, and the surprisingly long lives of bats and birds. Drawing on this grand evolutionary canvas, Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it.

The Molecule that Made the World

Oxygen

Transformer - the Deep Chemistry of Life and Death

Draws on cutting-edge scientific findings to chronicle the history of biological life, exploring a wide range of clues from gene sequences to the atomic structures of proteins to identify 10 key evolutionary developments that enabled consciousness, the creation of DNA and other building blocks. Reprint. A Scientific American Book Club and BOMC2 selection.

Life Ascending: The Ten Great Inventions of Evolution

Vital Question

From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.

Transformer: The Deep Chemistry of Life and Death

الأكسجين

Энергия, секс, самоубийство. Митохондрии и смысл жизни

evrimin on büyük icadı

Yaşamın Yükselişi

Michael J. Russell

Earnest Di Mauro

How Did Life Begin? There are two scientific views on the origins of life: 1) Earthly-Abiogenesis which argues life on Earth began on Earth, and 2) Extraterrestrial Abiogenesis the position of which is life has an ancestry which predates the origins of Earth, and is pervasive throughout the cosmos. Thus, both theories embrace abiogenesis" and both argue that life may have begun on innumerable planets via the same mechanisms. In this ground-breaking, revolutionary text, over 30 top scientists from around the world, explain how life began and if there is life on other worlds, in over 20 paradigm busting chapters. PART I: Earthly Abiogenesis & the Origins of Life 1. Why Does Life Start, What Does It Do, Where Will It Be, And How Might We Find It? Michael J. Russell, Ph.D., and Isik Kanik, Ph.D., 2. Just Like the Universe the Emergence of Life had High Enthalpy and Low Entropy Beginnings, Wolfgang Nitschke, Ph.D., and Michael J. Russell, Ph.D. 3. Polyphosphate-Peptide Synergy and the Organic Takeover at the Emergence of Life. E. James Milner-White, Ph.D., and Michael J. Russell, Ph.D. 4. The Alkaline World and the Origin of Life. Anthony Richard Mellersh, Ph.D., and Paul Michael Smith, 5. Amino Acid Homochirality and the RNA World: Necessities for Life on Earth, Koji Tamura, Ph.D., 6. The RNA World and the Origin of Life: An Ancient Protein Fold Links Metal-Based Gas Reactions with the RNA World. Anne Volbeda, Ph.D., Yvain Nicolet, Ph.D., and Juan C. Fontecilla-Camps, Ph.D. 7. Evolutionary Steps to the Origin of Life on Earth. Andrew J. Pratt, D. Phil. 8. Vesicles First and the Origin of Self-Reproductive Life: Metabolic Energy, Replication, and Catalysis. Arthur L. Koch, Ph.D., 9. Chance or Necessity? Bioenergetics and the Probability of Life. Nick Lane, Ph.D. 10. Disequilibrium First: The Origin of Life Christof B. Mast, Ph.D., Natan Osterman, Ph.D., and Dieter Braun, Ph.D. 11. Life's Origins: Potential for Radical Mediated Cyanide Production on the Early Earth, Shawn E. McGlynn, Ph.D., Trevor E. Beard, Joan B. Broderick, Ph.D., and John W. Peters, Ph.D. 12. The Emergence of Life: Thermodynamics of Chemical Free Energy Generation in Off-Axis Hydrothermal Vent Systems & Consequences for Compartmentalization & Life's Origins. Eugenio Simoncini, Ph.D., Axel Kleidon, Ph.D., Enzo Gallori, Ph.D. 13. How Life Began: The Emergence of Sparse Metabolic Networks, Shelley D. Copley, Ph.D., Eric Smith, Ph.D., and Harold J. Morowitz, Ph.D., 14. Redox Homeostasis in the Emergence of Life. On the Constant Internal Environment of Nascent Living Cells, John F. Allen, Ph.D. 15. Reconstruction of the Molecular Origin of Life. Edward N. Trifonov, Ph.D., 16. How Primordial Cells Assembled Biosynthetic Pathways, Marco Fondi, Ph.D., Giovanni Emiliani, Ph.D., Renato Fani, Ph.D., 17. On the Emergence of Pre-Genetic Information. Ernesto Di Mauro, Ph.D., 18. Implications For An RNA-Clay World: Interaction Of Cytosine With Clay Minerals, A. Pucci, Ph.D., et al. 19. Viruses and Life: Can There Be One Without the Other? Matti Jalasvuori, Ph.D., and Jaana K.H. Bamford, Ph.D., 20. The Origin of Eukaryotes: Archae, Bacteria, Viruses and Horizontal Gene Transfer, R. Joseph, Ph.D. 21. What Can the Origin of Life on Earth Tell Us About the Cosmos? Stephen Freeland, Ph.D., and Gayle K. Philip, Ph.D. PART II: Extra-Terrestrial Abiogenesis 22. 1. Biological Cosmology and the Origins of Life in the Universe, R. Joseph, Ph.D., Rudolf Schild, Ph.D 23. First Life in the Oceans of Primordial-Planets: The Biological Big Bang. C.H. Gibson, Ph.D., N.C. Wickramasinghe, Ph.D., R.E. Schild, Ph.D 24. Genetics Indicates Extra-Terrestrial Origins of Life: the First Gene. R. Joseph, Ph.D., Rudolf Schild, Ph.D., N.C. Wickramasinghe, Ph.D.,

Origins of Life How Life Began Abiogenesis, Astrobiology

For decades, biology has been dominated by information - the power of genes. Yet there is no difference in information content between a living cell and one that died a moment ago. A better question goes back to the formative years of biology: what processes animate cells and set them apart from lifeless matter? In Transformer, Nick Lane turns the standard view upside down, capturing an extraordinary scientific renaissance that is hiding in plain sight. At its core is an amazing cycle of reactions that uses energy to transform inorganic molecules into the building blocks of life - and the reverse. To understand this cycle is to fathom the deep coherence of the living world. It connects the origin of life with the devastation of cancer, the first photosynthetic bacteria with our own mitochondria, sulfurous sludges with the emergence of consciousness, and the trivial differences between ourselves with the large-scale history of our planet.

The Deep Chemistry of Life and Death

Transformer

Energie und Evolution

Der Funke des Lebens

"It is the Valley of Fear, the Valley of Death. The terror is in the hearts of the people from the dusk to the dawn" ﻿Crammed full of adventure, mystery and of course one or two rather brilliant deductions, The Valley Of Fear is Sir Arthur Conan Doyle's thrilling final Sherlock Holmes novel, brought to life in this spectacular new stage adaptation. A mysterious, coded message is received, a warning of imminent danger, drawing Sherlock Holmes and the faithful Dr Watson into a tale of intrigue and murder stretching from 221B Baker Street to an ancient moated manor house to the bleak Pennsylvanian Vermissa Valley. Faced with a trail of bewildering clues, Holmes begins to unearth a darker, wider web of corruption, a secret society and the sinister work of one Professor Moriarty. Following the huge success of Blackeyed Theatre's 2018/19 international tour of The Sign of Four, the great detective is back in another gripping stage adaptation by Nick Lane, combining original live music, stylish theatricality and magical story-telling for an unforgettable theatrical experience. The game is afoot!

Sherlock Holmes - The Valley of Fear - Stage Adaptation

Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.

Mitochondria and the meaning of life

The Valley of Fear

L. R. Stevenson

"Doctor Henry Jekyll is a good man. Successful within his field and respected by his peers, hes close to a neurological discovery that will change the face of medical science forever. However, his methods are less than ethical, and when a close friend and colleague threatens to expose and destroy his work, Jekyll is forced to experiment on himself, whereupon something goes very wrongor very right. And suddenly Jekyll has a new friend, the brutal Edward Hyde. A thrilling adaptation of Robert Louis Stevensons dark psychological fantasy, The Strange Case of Dr Jekyll And Mr Hyde immerses you in the myth and mystery of 19th century Londons fog-bound streets where love, betrayal and murder lurk at every chilling twist and turn. Gripping, stylish and thought-provoking, this is unmissable theatre. Go on. Treat your dark side!"

Nick Lane

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