Paolo Brambilla

Andrea Marini

This book provides a comprehensive review of new developments in the study of language processing and related neural networks in schizophrenia by addressing the complex link between psychopathology, language and evolution at different levels of analysis. Psychopathological symptoms in schizophrenia are mainly characterized by thought and language disorders, which are strictly intertwined. In particular, language is the distinctive dimension of human beings and is ontologically related to brain development. Although normal at the levels of segmental phonology and morphological organization, the speech of patients suffering from schizophrenia is often characterized by flattened intonation and word-finding difficulties. Furthermore, research suggests that the superior temporal gyrus and specific prefrontal areas which support language in humans are altered in people with schizophrenia. Brambilla and Marini bring together international contributors to explore the link between brain evolution and the psychopathological features of schizophrenia, with a focus on language and its neural underpinnings. Divided into three sections the book covers: • brain evolution and language phylogenesis • brain abnormalities in schizophrenia • psychopathology and schizophrenia. This theoretical approach will appeal to professionals including clinical psychologists, cognitive neuroscientists, neuropsychiatrists, neuropsychologists, neurolinguists, and researchers considering the links between brain evolution, language and psychopathology in schizophrenia.

Brain Evolution, Language and Psychopathology in Schizophrenia

Alfredo Carlo Altamura

Massimo Carlo Mauri

This book presents state of the art knowledge on the psychopathology, clinical symptomatology, biology, and treatment of hallucinations in patients with psychoses and affective disorders. The opening section describes and examines the origins of the hallucinatory symptoms associated with schizophrenia, bipolar disorders, and drug- or substance-induced psychoses. In addition, progress in understanding of hallucinations in children and adolescents and chronic hallucinatory disorder is reviewed, and the value of a Research Domain Criteria approach in elucidating the emergence of auditory hallucinations is explained. The biological basis of hallucinations is then closely scrutinized with reference to recent genetic research, neurochemical studies, and functional and structural neuroimaging data. Outcomes of a meta-analysis of diffusion tensor imaging studies regarding the association between white matter integrity and auditory verbal hallucinations are highlighted. The closing chapters focus on the roles of drug treatment and electric and magnetic brain stimulation techniques. The book will be of wide interest to psychiatrists and clinical psychologists.

A Clinical and Biological Approach

Hallucinations in Psychoses and Affective Disorders

Jair Soares

Consuelo Walss-Bass

Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness. Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomics Examines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorder Explores the interaction between genomic and environmental influences that shape behavior

Perspectives from Pediatric and High-Risk Populations

Bipolar Disorder Vulnerability

This case series book offers a practical and accessible approach to psychiatry, addressing major clinical problems ranging from psychosis to aging effects, each of which is tackled as it arises in everyday settings. With its emphasis on everyday practice strongly linked to underlying theory, the book combines clinical knowledge with the realities of managing clinical problems, and will provide a basis for developing sound analytical and confident decision-making skills. Presenting different visions of clinical psychiatry and expanding psychiatrists' interventions by integrating innovative neuroscience approaches such as neuroimaging, neuropsychology, TMS and cognitive rehabilitation, it will help clinicians and students alike gain a sound understanding of the wide range of signs and symptoms that indicate psychiatric disorders, and how the diagnosis, management and treatment options can differ from those in other medical specialties. The volume includes learning activities, with questions on each clinical case followed by detailed explanatory answers, and self-assessment exercises to assist with learning and revision. Throughout the book, tips and key features are highlighted with boxes, algorithms, tables and figures, which the reader can refer back to for exam revision and well into her/his career.

Integrating Translational Neuroscience Approaches

Clinical Cases in Psychiatry

This case series book offers a practical and accessible approach to psychiatry, addressing major clinical problems ranging from psychosis to aging effects, each of which is tackled as it arises in everyday settings. With its emphasis on everyday practice strongly linked to underlying theory, the book combines clinical knowledge with the realities of managing clinical problems, and will provide a basis for developing sound analytical and confident decision-making skills. Presenting different visions of clinical psychiatry and expanding psychiatrists’ interventions by integrating innovative neuroscience approaches such as neuroimaging, neuropsychology, TMS and cognitive rehabilitation, it will help clinicians and students alike gain a sound understanding of the wide range of signs and symptoms that indicate psychiatric disorders, and how the diagnosis, management and treatment options can differ from those in other medical specialties. The volume includes learning activities, with questions on each clinical case followed by detailed explanatory answers, and self-assessment exercises to assist with learning and revision. Throughout the book, tips and key features are highlighted with boxes, algorithms, tables and figures, which the reader can refer back to for exam revision and well into her/his career.

Clinical Cases in Psychiatry: Integrating Translational Neuroscience Approaches

Sudhakar Selvaraj

Jair C. Soares

Offering up-to-date information on brain imaging in mood disorders, this book is an invaluable resource for mental health professionals.

Paolo Brambilla

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