Paul J. Smith

Eddy W. Yue

One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular and functional entities, their involvement in different disease processes, and their potential for pharmacological modulation. With contributions from the top international researchers in the field, the book takes a contemporary approach to study the importance of rational drug design and knowledge-based therapeutics in relation to CDKs. The first two sections of the book discuss the integration of cell cycle control pathways, opportunities for targeting, targets of inhibitors, and the evaluation of CDK inhibitors, exploring topics such as the in vivo function of CDKs in normal homeostasisand tumor development and the structural biology of CDKs. The third section examines the design, development, and chemistry of small molecule CDK inhibitors, with discussions ranging from the early-stage discovery of new chemical entities with a capacity to inhibit CDKs to late-stage compounds in clinical development. The final section assesses the current status of CDK inhibitors in clinical trials, the therapeutic deployment challenges of small molecule inhibitors, and the future development of CDK inhibitors as anticancer agents. The field of drug development is at a critical point in terms of understanding the availability, advantages, and drawbacks of CDKs as therapeutic targets for small molecules. Providing the most up-to-date, in-depth coverage available in a single volume, Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents surveys the success of the agents developed thus far, the possibility of new routes to more selective inhibitors, and the growing appreciation of critical, therapeutic issues.

Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents

Drawing on the classical concept of rhetorical dispositio, this study gives new interpretations of a number of literary texts of the French Renaissance (Rabelais, Du Bellay, Montaigne and others). The often problematic ordering of these texts is studied from a variety of perspectives, historical, theoretical and cultural.

Dispositio: Problematic Ordering in French Renaissance Literature

Edward Lucie-Smith

Shows modern folk art in the form of textiles, jewelry, clothing, ceramics, glassware, silver, ironwork, furniture, quilts, and sculpture

Poetry of the Physical

Craft Today

This work examines the scale and root causes of terrorism across Southeast Asia, including the role of al-Qaeda's ascendancy in the region. It offers an overview of the analytical and theoretical framework for discussing the subject; and examines terrorism from functional and country-specific perspectives.

Transnational Challenges to States and Regional Stability

Terrorism and Violence in Southeast Asia

Tineke Kingma-Eijgendaal

Lectures de René Char

Paul Bogaards

Johan Rooryck

Du sommaire: Ambiguite et comprehension du langage (Paul Bogaards, Johan Rooryck). - Why pluralities don't mean a thing (Crit Cremers). - Aspects of interlingual ambiguity: polyglot punning (Dirk Delabastita). - Les feux de Saint-Antoine (Sjef Houppermans). - The semantics of Dutch moeten 'must, should, have to' from a typological and a relevance-theoretical perspective (Theo Janssen). - L'ambiguite en langue et en discours (Catherine Kerbrat-Orecchioni)."

articles sur l'ambiguïté offerts à Ronald Landheer

Quitte ou double sens

Tea growing was a prosperous industry in Sichuan when Wang Anshi's New Policies created a Tea Market Agency to buy up Sichuanese tea and trade it to Tibetan tribesmaen for cavalry horses. At first the highly autonomous agency not only acquired the needed horses but made a profit. After the Junchen conquest of Noth China, however, market realities changed and the combined Tea and Horse Agency's once successful policies ruined tea farmers, failed to meet quotas for horses, and ran a deficit. Paul J. Smith details the workings of Sichuan tea farming and the tea trade, examines the geopolitical factors that forced the Song to buy horses, and graphically describes the difficulties of driving them more than a thousand miles through rugged mountains with only inexperienced conscripts as trail hands. In this study of fiscal sociology, Smith also explains how the Tea and Horse Agency transformed the Sichuan local eleite, which was notorious for its resistance to state power, into imperial civil servants eager to tax their own region. He draws on modern theories of corporate behavior to explain what made the inner workings of the Agency an extraordinary departure for the Chinese civil service; and he demonstrates how the agency put into practice the most radical New -Policies theories of state economic activism. The Agency made entrepreneurs out of bureaucrats, but ultimately became ruinously tyrannical as the system of state rewards and punishments drove its personnel to actions that crippled key sectors of the economy.

Horses, Bureaucrats, and the Destruction of the Sichuan Tea Industry 1074-1224

Taxing Heaven's Storehouse

Anne-Pascale Pouey-Mounou

The French poets Ronsard and Du Bartas enjoyed a wide but varied reception throughout early modern Europe. This volume is the first book length monograph to study the transnational reception histories of both poets in conjunction with each other.

Ronsard and Du Bartas in Early Modern Europe

Paul Julian Smith

Tea growing was a prosperous industry in Sichuan when Wang Anshi's New Policies created a Tea Market Agency to buy up Sichuanese tea and trade it to Tibetan tribesmen for cavalry horses. At first the highly autonomous Agency not only acquired the needed horses but made a profit. After the Jurchen conquest of North China, however, market realities changed and the combined Tea and Horse Agency's once successful policies ruined tea farmers, failed to meet quotas for horses, and ran a deficit. Smith details the workings of Sichuan tea farming and the tea trade, examines the geopolitical factors that forced the Song to buy horses, and graphically describes the difficulties of driving them more than a thousand miles through rugged mountains with only inexperienced conscripts as trail hands. In this study of fiscal sociology, Smith also explains how the Tea and Horse Agency transformed the Sichuan local elite, which was notorious for its resistance to state power, into imperial civil servants eager to tax their own region. He draws on modern theories of corporate behavior to explain what made the inner workings of the Agency an extraordinary departure for the Chinese civil service; and he demonstrates how the Agency put into practice the most radical New-Policies theories of state economic activism. The Agency made entrepreneurs out of bureaucrats, but ultimately became ruinously tyrannical as the system of state rewards and punishments drove its personnel to actions that crippled key sectors of the economy.

Horses, Bureaucrats, and the Destruction of the Sichuan Tea Industry, 1074-1224

Annelies Schulte Nordholt

Jeux de mots célèbre le pouvoir créateur des jeux de langage dans la littérature de Rabelais à Richard Millet. Calembour, mot-valise, bon mot, néologisme, mot-fétiche : ce volume collectif explore la productivité des mots en prose et en poésie. Jeux de mots celebrates the creative power of wordplay from Rabelais to present times. Puns, portmanteaus, ‘bon mots’, neologisms, fetish-words: this collective volume explores the productivity of words in prose and poetry.

Essais en hommage à Sjef Houppermans

Jeux de mots - enjeux littéraires

Karl A.E. Enenkel

This interdisciplinary volume aims to address the multiple connections between emblematics and the natural world in the broader perspective of their underlying ideologies – scientific, artistic, literary, political and/or religious.

Emblems and the Natural World

This bilingual (English-French) anthology of early modern fictitious catalogues presents a multitude of texts, from the genre’s beginnings (Rabelais’s satirical catalogue of the Library of St.-Victor (1532)) to its French and Dutch specimens from around 1700.

A Scholarly Anthology

Early Modern Catalogues of Imaginary Books

Karl A. E. Enenkel

This volume tries to map out the intriguing amalgam of different, partly conflicting approaches that shaped early modern zoology. It demonstrates that theology and philology played a pivotal role in the complex formation of this new science.

Paul J. Smith

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