Philip Dawson

This stylishly designed book tells the fascinating story of the greatness and glamour of the ocean liner. For the first time in paperback, the history of these vessels is recounted with full exploration into their design, construction and development, along with a social history of those who worked and travelled on them. The well-known perennial favourites such as Mauretania, Olympic, Titanic, Bremen, Europa and the Cunard Queens are looked at in a fresh light in the context of emerging and changing lifestyles. The book also offers detailed information on some of the lesser known but significant ships such as l'Atlantique, Empress of Britain and Cap Arcona. The story is brought full circle with a discussion of the liner's increasing influence on cruise ship design and the Queen Mary 2, which initiated a new liner era for the twenty-first century.

Retrospective & Renaissance

The Liner

Igor L. Medintz

W. Russ Algar

This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

Concepts and Applications

Chemoselective and Bioorthogonal Ligation Reactions

Timothy Tackett

John Markoff

Gilbert Shapiro

This pathbreaking work reports on the methods, and some of the results, of a content analysis of the cahiers de doléances, the well-known lists of grievances in which, in 1789, the French people expressed their dissatisfactions with the state of their society and their hopes for a better future. The analysis is an outgrowth of a larger research project, "Quantitative Studies of the French Revolution," conducted by the authors and others over a thirty-year period. The central data of the research for this book are a coding of a national sample of documents representing the views of rural parishes, the Nobility, and the Third Estate. These codes, together with data on the economic, social, and political conditions of the regions of France under the Old Regime and data on political behavior during the revolutionary period, form a computerized data archive to be made available to researchers. The book is in four parts. Part I describes content analysis as a method and its varieties, controversies, and problems. Part II discusses the cahiers and their authenticity and usefulness as a historical source. Part III considers the coding procedures, information about the sample, and studies bearing on the evaluation of the coding process. Part IV, the largest part of the book, presents some of the authors' findings to date, including a summary of the concerns expressed by the nation in 1789, a study of the attitudes toward the monarchy, an analysis of consensus and conflict among the Estates, and the influence of social mobility upon political radicalism. Appendixes provide details of the coding, the national frequencies of many grievance categories, lists of sources of coded cahiers, and maps indicating the data's coverage of France.

A Content Analysis of the Cahiers de Doléances of 1789

Revolutionary Demands

Fernand Nicolaÿ

Dawson contributes research findings to the historical controversy over the political motives and conduct of the upper bourgeoisie during the French Revolution, treating magistrates' activities as members of corporate groups before 1790 and following many of them as individuals through the revolutionary years to 1795.

Provincial Magistrates and Revolutionary Politics in France, 1789-1795

Lei Liu

Ashraf Brik

How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.

Total Chemical Synthesis of Proteins

Their Construction and Operation. A Practical Handbook, Setting Forth ... the Modern Application of Electricity as a Motive Power for Railways and Tramways ... and Describing in Detail the Principal Installations of Europe and America

Philip Dawson

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