Ram Prasad

Pranav Kumar Prabhakar

Ponnurengam Malliappan Sivakumar

As we know diabetes mellitus is the most common metabolic endocrine disorder. According to the WHO and American Diabetes Mellitus, diabetes mellitus is the 3rd leading cause of death if we were to include all secondary complications. However without including secondary complications, it is 7th place in mortality and morbidity. The point to be considered in the case of diabetes mellitus is the secondary complications caused in this condition. Almost all organs affected by diabetes and results in a potentially worse condition. The major secondary complications are neuropathy, nephropathy, retinopathy, and diabetes foot microvascular and macrovascular complications. The long term complications grow slowly in the case of diabetes. As the time living with diabetes becomes longer, controlled glucose levels will be more difficult to achieve, meaning there there will be more long term complications. The aim of the current Research Topic on the secondary complications of diabetes and their management is to publish good quality research articles as well as reviews, which should address the management of diabetes, abnormalities of secondary complications and other disease involved in diabetes. Potential Topics includes but not restricted to: • Secondary complications of diabetes mellitus • Microvascular and macrovascular complications • The role of oxidative stress in the diabetes burden • New insights in glycemic control • New strategies/ approaches to manage secondary complications such as Stearoyl CoA dismutase, Acetyl CoA Carboxylase, Adiponectin/ Adipocyte complement-related protein 30, Hormone Sensitive Lipase (HSL) Inhibitors • Recent development in the therapeutic approaches for glucose management such as Protein tyrosine phosphatase-1B (PTP1B) inhibitors, Glycogen synthase kinase-3 (GSK3) inhibitors, β3- Adrenergic receptor agonist, Retinoid X receptor, PPARα agonist, AMP activated protein kinase • Development of new target as a target for antihyperglycemic drug designing

Advanced Approaches in the Diagnosis and Treatment of Diabetes Mellitus and Secondary Complications

Shachi Shah

V. Venkatramanan

Global climate change threatens human existence through its potential impact on agriculture and the environment. Agriculture is climate-sensitive, and climate variability and climate change have net negative impact on it. Additionally, the agricultural landscape is affected by monoculture and agro-biodiversity loss, soil fertility depletion and soil loss, competition from biofuel production, crop yield plateaus and invasive species. Nevertheless, the global agricultural production system has to meet the food demands from the growing human population, which is set to exceed 10 billion by 2050. This book discusses the impacts of climate change on agriculture, animal husbandry and rural livelihoods. Further, since agriculture, forestry and other land-use sectors contribute about 10–12 gigatonnes of CO2-equivalent per year, it argues that agricultural policy must dovetail adaptation and mitigation strategies to reduce greenhouse gases emissions. This calls for a reformative and disruptive agricultural strategy like climate-smart agriculture, which can operate at all spatio-temporal scales with few modifications. The book also redefines sustainable agriculture through the lens of climate-smart agriculture in the context of the sustainability of Earth's life- support system and inter- and intra-generational equity. The climate-smart agriculture approach is gaining currency thanks to its inherent positive potential, and its goal to establish an agricultural system which includes "climate-smart food systems", "climate-proof farms", and "climate-smart soils". Climate-smart agriculture provides a pathway to achieve sustainable development goals which focus on poverty reduction, food security, and environmental health.

Agriculture Perspectives

Global Climate Change and Environmental Policy

This book provides essential insights into methods and practices of ‘Climate-smart Agriculture,’ which is driven by the principles of climate resilience and smart resource use in agricultural production. Climate-smart agriculture is a key policy instrument for achieving poverty eradication and a hunger-free world, as well as mitigating the effects of climate change. This book discusses in detail climate-smart agricultural technologies and practices that can reduce the vulnerability of agricultural systems, improve the livelihoods of farmers and other stakeholders, and reduce the greenhouse gas emissions from crop production and livestock husbandry. The agriculture, forestry and other land use (AFOLU) sector produces roughly 10–12 gigatons of CO2-equivalent per year; therefore, sustainable practices for agriculture and related land use hold immense potential to mitigate climate change. The potential impacts of climate variability and climate change on agriculture are extensively documented and articulated, especially with regard to global and national environmental agendas that call for innovation, transformation and climate-resilient advances in agriculture. As the book demonstrates, climate-smart agriculture offers an excellent tool for boosting agricultural output to feed the growing global population; for reducing greenhouse gases emissions from agriculture and other land use; and for protecting agricultural production systems from the impending dangers of climate change.

Global Climate Change: Resilient and Smart Agriculture

Sustainable development is the most important challenge facing humanity in the 21st century. The global economic growth in the recent past has indeed exhibited marked progress in many countries. Nevertheless, the issues of income disparity, poverty, gender gaps, and malnutrition are not uncommon in the global landscape, in spite of the upward growth of the economy and technological advances. This grim picture is further exacerbated by our growing human population, unmindful resource use, ever-increasing consumption trends, and changing climate. In order to protect humanity and preserve the planet, the United Nations issued the “2030 agenda for sustainable development,” which includes but is not limited to sustainable production and consumption practices, e.g. in a sustainable bioeconomy. The hallmark of the sustainable bioeconomy is a paradigm shift from a fossil-fuel-based economy to a biological-based one, which is driven by the virtues of sustainability, efficient utilization of resources, and “circular economy.” As the sustainable bioeconomy is based on the efficient utilization of biological resources and societal transformations, it holds the immense potential to achieve the UN’s Sustainable Development Goals. This book shares valuable insights into the linkages between the sustainable bioeconomy and Sustainable Development Goals, making it an essential read for policymakers, researchers and students of environmental studies.

Pathways to Sustainable Development Goals

Sustainable Bioeconomy

Inamuddin

Mohd Imran Ahamed

This comprehensive edited book on microbial prospective discusses the innovative approaches and investigation strategies, as well as provides a broad spectrum of the cutting-edge research on the processing, properties and technological developments of microbial products and their applications. Microbes finds very important applications in our lives including industries and food processing. They are widely used in the fermentation of beverages, processing of dairy products, production of pharmaceuticals, chemicals, enzymes, proteins and biomaterials; conversion of biomass into fuel, fuel cell technology, health and environmental sectors. Some of these products are produced commercially, while others are potentially valuable in biotechnology. Microorganisms are considered invaluable in research as model organisms. This is a useful compilation for students and researchers in microbiology, biotechnology and chemical industries.

Application of Microbes in Environmental and Microbial Biotechnology

Microbial Nanobionics: Volume 1, State of the Art, discusses a wide range of microbial systems and their utilization in biogenic synthesis of metallic nanoparticles. The rich biodiversity of microbes makes them excellent candidates for potential nanoparticle synthesis biofactories. Through a better understanding of the biochemical and molecular mechanisms of the microbial biosynthesis of metal nanoparticles, the rate of synthesis can be better developed and the monodispersity of the product can be enhanced. The characteristics of nanoparticles can be controlled via optimization of important parameters, such as temperature, pH, concentration and pressure, which regulate microbe growth conditions and cellular and enzymatic activities. Large scale microbial synthesis of nanoparticles is a sustainable method due to the non-hazardous, non-toxic and economical nature of these processes. The applications of microbial synthesis of nanoparticles are wide and varied, spanning the industrial, biomedical and environmental fields. Biomedical applications include improved and more targeted antimicrobials, biosensing, imaging and drug delivery. In the environmental fields, nanoparticles are used for bioremediation of diverse contaminants, water treatment, catalysis and production of clean energy. With the expected growth of microbial nanotechnology, this volume will serve as a comprehensive and timely reference.

Volume 1, State-of-the-Art

Microbial Nanobionics

Ajit Varma

Bhoopander Giri

The book ‘Root Biology’ written by experts in the field, covers latest research on cellular, genetic, physiological and ecological developmental facets of root growth as well as the interaction of root with an array of microbes whether for the establishment of symbiosis, increasing plant growth or protecting plant from pathogens/attackers. Plant roots provide an excellent model to study physiological, developmental and metabolic processes at a system level. Root system architecture - an excellent creation of nature, is closely interconnected with the availability of soil nutrients. Several strategies including biotechnological interventions are gaining interest and importance for sustainable food production and enhanced resource acquisition. Such strategies have largely focused on root traits for efficient utilization of soil resources. The biotechnological application of root biology is expected to promote the production of food while maintaining ecologically and economically sustainable production systems. With a fortune of information on technical and experimental aspects useful in the laboratory, this extensive book is a valuable resource for researchers, academician and students in the broad field of microbiology, plant and fungal biology.

Root Biology

Manoj Kaushal

This edited volume is a comprehensive account of plant diseases and insect pests, plant protection and management for various crops using microbial and biotechnological approaches. The book elucidates the role of biotechnology for the enhancement of crop productivity and management of bacterial and fungal diseases via eco-friendly methods. It discusses crop–pest⁄ pathogen interaction and utilizing this interaction in a beneficial and sustainable way. This book is of interest to teachers, researchers, plant scientists and plant pathologists. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences.

Microbial Biotechnology in Crop Protection

Vivek Kumar

Manoj Kumar

This book highlights the implications of nanotechnology and the effects of nanoparticles on agricultural systems, their interactions with plants as well as their potential applications as fertilizers and pesticides. It also discusses how innovative, eco-friendly approaches to improve food and agricultural systems lead to increased plant productivity. Further, it offers insights into the current trends and future prospects of nanotechnology along with the benefits and risks and their impact on agricultural ecosystems. Nanomaterials in agriculture reduce the amount of chemical products sprayed by means of smart delivery of active ingredients; minimize nutrient losses in fertilization; and increase yields through optimized water and nutrient management. There is also huge potential for nanotechnology in the provision of state-of-the-art solutions for various challenges faced by agriculture and society, both today and in the future.

An Agricultural Paradigm

Nanotechnology

Bioremediation is the use of microorganisms' metabolism to degrade waste contaminants (sewage, domestic, and industrial effluents) into non-toxic or less toxic materials by natural biological processes. Remediation through fungi—or mycoremediation—has multifarious possibilities in applied remediation engineering and the future of environmental sustainability. Fungi have the biochemical and ecological capability to degrade environmental organic chemicals and to decrease the risk associated with metals, semi-metals, noble metals, and radionuclides, either by chemical modification or by manipulating chemical bioavailability. Additionally, the capability of these fungi to form extended mycelia networks, the low specificity of their catabolic enzymes, and their using pollutants as a growth substrate make these fungi well suited for bioremediation processes. Their mycelia exhibit the robustness of adapting to highly limiting environmental conditions often experienced in the presence of persistent pollutants, which makes them more useful compared to other microbes. However, despite dominating the living biomass in soil and being abundant in aquatic ecosystems, fungi have not been exploited for the bioremediation of such environments. This book covers the various types of fungi and associated fungal processes used to clean up waste and wastewaters in contaminated environments and discusses future potential applications.

Volume 1

Mycoremediation and Environmental Sustainability

Devendra K. Choudhary

This book explores the role of in silico deployment in connection with modulation techniques for improving sustainability and competitiveness in the agri-food sector; pharmacokinetics and molecular docking studies of plant-derived natural compounds; and their potential anti-neurodegenerative activity. It also investigates biochemical pathways for bacterial metabolite synthesis, fungal diversity and plant-fungi interaction in plant diseases, methods for predicting disease-resistant candidate genes in plants, and genes-to-metabolites and metabolites-to-genes approaches for predicting biosynthetic pathways in microbes for natural product discovery. The respective chapters elaborate on the use of in situ methods to study biochemical pathways for bacterial metabolite synthesis; tools for plant metabolites in defence; plant secondary metabolites in defence; plant growth metabolites; characterisation of plant metabolites; and identification of plant derived metabolites in the context of plant defence. The book offers an unprecedented resource, highlighting state-of-the-art research work that will greatly benefit researchers and students alike, not only in the field of agriculture but also in many disciplines in the life sciences and plant sciences.

In Silico Approach for Sustainable Agriculture

Shyambhavee Behera

Basanta Kumara Bahera

Basic principles of applied life sciences such as recombinant DNA technology is used in most life sciences industries marketing bio-formulations for designing more effective protein-based drugs, such as erythropoietin and fast-acting insulin etc. In recent times genetically engineered host cells from mammal, animal and plants are also being used in life sciences industries to manufacture biologics. This book discusses the most basic as well advanced issues on biological products for successfully managing a life sciences industry. It elucidates the life cycle of biological molecules, right from the conceptual development of different types of biopolymers, and their subsequent transfer from the conical flasks in laboratory to life sciences industries for large scale production and marketing. It focuses on sustainable longevity in the life cycle of commercial biopolymers. Cumulative facts and figures in this volume would immensely help in inspiring life sciences industry promoters to monitor value chain transfer process of biologics for better profitability. Additionally, it would serve as a perusal document for the students and researchers interested in entrepreneurial ventures or having their own start-up projects for the commercialization of biologics.

From Laboratories to Commercialization of Research

Life Sciences Industry

Microbial biosurfactant compounds are a group of structurally diverse molecules produced by microorganisms, and are mainly categorized according to their chemical structure. The diversity of microbial biosurfactants makes them versatile and means that they offer a range of capabilities, while at the same time being economically sustainable. As such, they have potential applications in environmental processes, as well as in food, biomedicine and other industries. This book discusses innovative approaches and cutting-edge research that utilize the various properties of biosurfactants. Drawing on research from around the globe, it provides an up-to-date review of biosurfactant applications and their importance in fields such as medicine, gene therapy, immunotherapy, antimicrobial bioremediation and agriculture. It also discusses their anti-adhesive properties. The book will appeal to academics and researchers in the field of microbiology, as well as policymakers. It also serves as additional reading material for undergraduate and graduate students of agriculture, ecology, soil science, and environmental sciences.

Preparation, Properties and Applications

Microbial Biosurfactants

Plant Nanobionics, Volume 2 continues the important discussion of nanotechnology in plants, but focuses with a focus on biosynthesis and toxicity. This book discusses novel approaches to biosynthesis of nanoparticles for the increase of plant production systems, controlled release of agrochemicals and management of plant biotic stress. Green biosynthesis of metallic nanoparticles from bee propolis, artificial photosynthesis and hybrid structures are presented. Although engineered nanoparticles have great potential for solving many agricultural and societal problems, their consequences on the ecosystems and environment must be responsibly considered. This volume aims to contribute to the limited literature on this topic through its comprehensive examination of nanoparticle toxicity on plants, microbes and human health. Environmental risks with recent data are discussed as well as risks associated with the transfer of nanoparticles through the food chain. This volume highlights the study of a mechanistic approach and the study of nanoparticles towards nanobionics. The application of polymeric materials for smart packing in the food industry and agriculture sector as well as the future of nanomaterials in detecting soil microbes for environmental remediation are also included.

Volume 2, Approaches in Nanoparticles, Biosynthesis, and Toxicity

Plant Nanobionics

Qiang-Sheng Wu

This book provides a comprehensive overview of the benefits of biofertilizers as an alternative to chemical fertilizers and pesticides. Agricultural production has increased massively over the last century due to increased use of chemical fertilizers and pesticides, but these gains have come at a price. The chemicals are not only expensive; they also reduce microbial activity in agricultural soils and accumulate in the food chain, with potentially harmful effects for humans. Accordingly, it is high time to explore alternatives and to find solutions to overcome our increasing dependence on these chemicals. Biofertilizers, which consist of plant remains, organic matter and microorganisms, might offer an alternative. They are natural, organic, biodegradable, eco-friendly and cost-effective. Further, the microbes present in the biofertilizers are important, because they produce nutrients required for plant growth (e.g., nitrogen, phosphorus, potassium), as well as substances essential for plant growth and development (e.g., auxins and cytokinins). Biofertilizers also improve the physical properties, fertility and productivity of soil, reducing the need for chemical fertilizers while maintaining high crop yield. This makes biofertilizers a powerful tool for sustainable agriculture and a sustainable environment. The book covers the latest research on biofertilizers, ranging from beneficial fungal, bacterial and algal inoculants; to microbes for bioremediation, wastewater treatment; and recycling of biodegradable municipal, agricultural and industrial waste; as well as biocontrol agents and bio-pesticides. As such, it offers a valuable resource for researchers, academics and students in the broad fields of microbiology and agriculture.

Biofertilizers for Sustainable Agriculture and Environment

Swati Tripathi

This book highlights recent advances in the field of plant-biotic interactions and explores current serious issues in the crop production industry. It is intended to attract more attention to these important, but often overlooked areas, and to stimulate new ideas for future research. Plants are constantly under attack by pathogens, pests, and parasites, which can significantly impact worldwide food production and human health. While pathogens and pests attack and interconnect with their hosts in a variety of ways, plants have developed sophisticated immune systems to fight infections. In the field of plant-biotic interactions, most of the studies to date have focused on the function and signaling pathways of plant disease resistance proteins and pattern recognition receptors, as well as pathogen effector proteins. In contrast, this book presents new and emerging research areas, and introduces students, researchers, academics, and policy advisors to the latest trends in e.g. microbial technology, environmental microbiology, agricultural science, the health sciences, biological sciences and other related disciplines.

State of the Art

Plant Biotic Interactions

Sarvajeet Singh Gill

Narendra Tuteja

Crop Improvement through Microbial Biotechnology explains how certain techniques can be used to manipulate plant growth and development, focusing on the cross-kingdom transfer of genes to incorporate novel phenotypes in plants, including the utilization of microbes at every step, from cloning and characterization, to the production of a genetically engineered plant. This book covers microbial biotechnology in sustainable agriculture, aiming to improve crop productivity under stress conditions. It includes sections on genes encoding avirulence factors of bacteria and fungi, viral coat proteins of plant viruses, chitinase from fungi, virulence factors from nematodes and mycoplasma, insecticidal toxins from Bacillus thuringiensis, and herbicide tolerance enzymes from bacteria. Introduces the principles of microbial biotechnology and its application in crop improvement Lists various new developments in enhancing plant productivity and efficiency Explains the mechanisms of plant/microbial interactions and the beneficial use of these interactions in crop improvement Explores various bacteria classes and their beneficial effects in plant growth and efficiency

Crop Improvement through Microbial Biotechnology

New and Future Developments in Microbial Biotechnology and Bioengineering

This is the fourth updated and revised edition of a well-received book that emphasises on fungal diversity, plant productivity and sustainability. It contains new chapters written by leading experts in the field. This book is an up-to-date overview of current progress in mycorrhiza and association with plant productivity and environmental sustainability. The result is a must hands-on guide, ideally suited for agri-biotechnology, soil biology, fungal biology including mycorrhiza and stress management, academia and researchers. The topic of this book is particularly relevant to researchers involved in mycorrhiza, especially to food security and environmental protection. Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the pre sence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.

Mycorrhiza - Eco-Physiology, Secondary Metabolites, Nanomaterials

Devarajan Thangadurai

Jeyabalan Sangeetha

This book focuses on the application of nanotechnology in medicine and drug delivery, including diagnosis and therapy. Nanomedicine can contribute to the development of a personalized medicine both for diagnosis and therapy. By interacting with biological molecules at nanoscale level, nanotechnology opens up an immense field of research and applications. Interactions between artificial molecular assemblies or nanodevices and biomolecules can be understood both in the extracellular medium and inside human cells. Operating at nanoscale allows exploitation of physical properties different from those observed at microscale, such as the volume to surface area ratio. A number of clinical applications of nanobiotechnology, such as disease diagnosis, target-specific drug delivery, and molecular imaging are being investigated. Some promising new products are also undergoing clinical trials. Such advanced applications of this approach to biological systems will undoubtedly transform the foundations of diagnosis, treatment, and prevention of disease in the future. Nanomedicine sales reached $16 billion in 2015, with a minimum of $3.8 billion in nanotechnology R&D being invested each year. Global funding for emerging nanotechnology increased by 45% per year in recent years, with product sales exceeding $1 trillion in 2013. As the nanomedicine industry continues to grow, it is expected to have a significant impact on the global economy. This book provides clear, colorful and simple illustrations, tables, and case studies to clearly convey the content to a general audience and reader. This book also discusses the development of nanobiomaterials from biogenic (biological sources) systems for healthcare and disease therapies. This book, therefore, is useful for researchers and academicians in the fields of nanotechnology, medicine, nano-biotechnology and pharmacology.

From Biomolecules to Nanoparticles

Functional Bionanomaterials

This book addresses “phyto-microbiome mediated stress regulation”. Fundamentally speaking, the microbial community’s importance for the survival of plants under stress conditions has already been confirmed. This book focuses on the roles of those rhizospheric microbiomes that are advantageous to plant developmental pathways. Gathering contributions by authors with specialized expertise in plant growth and health under stress conditions, as well as opportunistic pathogenic bacteria, the book reviews the functional aspects of rhizospheric microorganisms and how they impact plant health and disease. It offers a compendium of plant and microbial interactions at the level of multitrophic interactions, and identifies gaps between future demand and present research on plant stress. In closing, the authors highlight several directions for reshaping rhizosphere microbiomes in favor of microorganisms that are beneficial to plant growth and health.

Ram Prasad

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