Robert A. Scott

R. Bruce King

Edward I. Solomon

Over the past several decades there have been major advances in ourability to computationally evaluate the electronic structure ofinorganic molecules, particularly transition metal systems. Thisadvancement is due to the Moore’s Law increase in computingpower as well as the impact of density functional theory (DFT) andits implementation in commercial and freeware programs for quantumchemical calculations. Improved pure and hybrid density functionalsare allowing DFT calculations with accuracy comparable tohigh-level Hartree-Fock treatments, and the results of thesecalculations can now be evaluated by experiment. When calculations are correlated to, and supported by,experimental data they can provide fundamental insight intoelectronic structure and its contributions to physical propertiesand chemical reactivity. This interplay continues to expand andcontributes to both improved value of experimental results andimproved accuracy of computational predictions. The purpose of this EIC Book is to provide state-of-the-artpresentations of quantum mechanical and related methods and theirapplications, written by many of the leaders in the field. Part 1of this volume focuses on methods, their background andimplementation, and their use in describing bonding properties,energies, transition states and spectroscopic features. Part 2focuses on applications in bioinorganic chemistry and Part 3discusses inorganic chemistry, where electronic structurecalculations have already had a major impact. This addition to theEIC Book series is of significant value to both experimentalistsand theoreticians, and we anticipate that it will stimulate bothfurther development of the methodology and its applications in themany interdisciplinary fields that comprise modern inorganic andbioinorganic chemistry. This volume is also available as part of Encyclopedia ofInorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007to 2010, representing areas of key developments in the field ofinorganic chemistry published in the Encyclopedia of InorganicChemistry. ahref="http://eu.wiley.com/WileyCDA/WileyTitle/productCd-1119994284.html"Findout more/a.

Computational Inorganic and Bioinorganic Chemistry

Valeria Culotta

Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.

Metals in Cells

A. Grant Mauk

One of the most heavily researched proteins in existence, cytochrome c has proved irresistible to chemists and biophysicists for decades. This volume serves as a source book to update the vast body of literature compiled on this protein over the last 40 years. Chapters from an internationally renowned group of experts provide extensive coverage of structural studies, spectroscopic properties, thermodynamic properties, electron transfer kinetics and protein modification. "... a valuable addition to the cytochrome literature; I will certainly get a copy for my group." Dr G. R. Moore, University of East Anglia "For any and all students of the science of cytochrome c, this is an indispensable text." SIM News

A Multidisciplinary Approach

Cytochrome C

Charles M. Lukehart

Modern spectroscopic and instrumental techniques are essential tothe practice of inorganic and bioinorganic chemistry. This firstvolume in the new Wiley Encyclopedia of Inorganic ChemistryMethods and Applications Series provides a consistent andcomprehensive description of the practical applicability of a largenumber of techniques to modern problems in inorganic andbioinorganic chemistry. The outcome is a text that providesinvaluable guidance and advice for inorganic and bioinorganicchemists to select appropriate techniques, whilst acting as asource to the understanding of these methods. This volume is also available as part of Encyclopedia ofInorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007to 2010, representing areas of key developments in the field ofinorganic chemistry published in the Encyclopedia of InorganicChemistry. ahref="http://eu.wiley.com/WileyCDA/WileyTitle/productCd-1119994284.html"Findout more/a.

Applications of Physical Methods to Inorganic and Bioinorganic Chemistry

Connecting inorganic chemistry to the hottest topic in materials science, this timely resource collects the contributions made by leading inorganic chemists towards nanomaterials research. The second volume in the “Wiley Encyclopedia of Inorganic Chemistry Methods and Applications Series,” this signature title concentrates on recent developments in the field and includes all key topics such as nanowires, nanotubes, biomineralization, supramolecular materials and much more. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more.

Inorganic and Bioinorganic Perspectives

Nanomaterials

Michael K. Johnson

Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Metalloprotein Active Site Assembly

The disability of blindness is a learned social role. The various attitudes and patterns of behavior that characterize people who are blind are not inherent in their condition but, rather, are acquired through ordinary processes of social learning. The Making of Blind Men is intended as a systematic and integrated overview of the blindness problem in America. Dr. Scott chronicles which aspects of this problem are being dealt with by organizations for the blind and the effectiveness of this intervention system. He details the potential consequences of blind people becoming clients of blindness agencies by pointing out that many of the attitudes, behavior patterns, and qualities of character that have been assumed to be given to blind people by their condition are, in fact, products of socialization. As the self-concepts of blind men are generated by the same processes of socialization that shape us all, Dr. Scott puts forth the challenge of reforming the organized intervention system by critically evaluating the validity of blindness workers' assumptions about blindness and the blind. It is felt that an enlightened work force can then render the socialization process of the blind into a rational and deliberate force for positive change.

The Making of Blind Men

Explores reports of Christian pilgrimages to find miracle cures for illness at medieval, early modern, and contemporary shrines.

Saints, Pilgrimage, and the Healing Powers of Belief

Miracle Cures

Robert A. Scott explores why medieval people built Gothic cathedrals, how they built them, what conception of the divine lay behind their creation and the social and political uses made of cathedrals by religious and secular leaders.

Robert A. Scott

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