Robert Marcus

Kenneth C. Anderson

Stephen A. Schey

Kwee L. Yong

Myeloma is the second-most common hematologic cancer, accounting for approximately 1 percent of all cancers and 2 percent of all deaths from cancer. In recent years there have been major and significant advances in the diagnosis, imaging, molecular pathogenesis, and therapy of myeloma. This book describes these advances in a single, practical volume, placing them in the context of daily clinical practice. Different myeloma subtypes are discussed in individual chapters, integrating etiology, pathogenesis, molecular pathology, histology, and therapy in a single place for each condition. The book begins by discussing epidemiology, imaging techniques, pathogenesis, and other general considerations. Conditions covered in detail include multiple myeloma, POEMS syndrome, Castleman's syndrome, Waldenstrom's macroglobulinemia, amyloidosis and MGUS. Featuring color illustrations, and written and edited by leading authorities in the field, Myeloma provides readers with the information they need to diagnose and manage these complex disorders.

Pathology, Diagnosis, and Treatment

Myeloma

Michael A. Levine

John P. Bilezikian, MD

Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians. Key Features * Offers objective and authoritative reviews on controversial clinical issues * Written by world experts on parathyroid hormone and its disorders * Superb, state-of-the-art compendium in one convenient volume * Bridges basic science of parathyroid hormone to major clinical disorders * Practical information on clinical management of parathyroid hormone disorders

Basic and Clinical Concepts

The Parathyroids

John P. Bilezikian

John T. Potts Jr.

Claudio Marcocci

Shonni J Silverberg

The third edition of The Parathyroids, led by a new stellar editorial team, has been thoroughly updated to reflect the considerable advances in just about every aspect of PTH biology over the past decade. It continues to be the authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium. This translational resource is invaluable to graduate students, fellows, researchers, and research clinicians in the fields of endocrinology, bone biology, osteology, and rheumatology. Contains chapters and information on noninvasive imaging, fracture healing, secondary diseases such as CKD, Vitamin D, cell signaling pathways, vascular calcification, as well as advances in genetics/genomics Includes essential updates on the critical importance of Vitamin D insufficiency and its relationship to secondary hyperparathyroidism Offers new insights into the underlying mechanisms of parathyroid hormone actions on osteocytes and sclerostin Examines essential updates in the understanding of secondary hyperparathyroidism associated with chronic kidney disease, facture healing, and vascular disease

David Feldman

Dorothy Nelson

Clifford Rosen

Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year. NEW TO THIS EDITION: *Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere

Osteoporosis

Rogerio A. Lobo

Jennifer Kelsey

Menopause: Biology and Pathobiology is a comprehensive volume covering all aspects of the biology, anatomy, physiology, pathobiology, and pharmacology of menopause, as well as its diagnosis and management. The book is divided into four sections: Basic Biology, Epidemiology, Menopausal Systems Pathophysiology, and Intervention. Basic Biology covers such fundamentals as ovarian anatomy and physiology, mechanisms of steroid hormone action, chronobiological effects, and premature menopause. Epidemiology includes, among others, chapters on methodology challenges in the study of menopause, how to distinguish the effects of age from those of menopause, and a discussion of the key differences in demographics, environmental factors, and ethnicity in the menopause experience. The Pathophysiology section contains chapters on menopause and its various effects on the body, including sexuality, skin, brain, the cardiovascular system, cancers, and mood. The final section includes detailed chapters on intervention and management techniques, with topics including alternative therapies to hormone replacement, exercise, and estrogens and osteoporosis. * Well-referenced to allow easy look up of anything related to menopause * Presents the latest thinking on basic science and clinical topics * Exposes what the current gaps in our knowledge are * Presents current expert opinions

Biology and Pathobiology

Menopause

Emerging Technology Strategies and the Great Global Grid The next generation of the Internet will produce dramatic economic and social changes exceeding even the World Wide Web. Several emerging technologies are converging to create a Great Global Grid infrastructure where universal connectivity to large computing resources will be available for consumers and enterprises. The goal of this book is to provide a systematic survey of the full spectrum of Great Global Grid technologies from an enterprise viewpoint. The Great Global Grid - The range of technologies comprising the Great Global Grid is very wide. One of the main contributions of the book is to categorize these technologies in detail and to explain the dependencies among them. The technologies include: Application Servers and Portals Enterprise Application Integration and B2B Middleware Web Services and XML Messaging Peer-to-Peer Collaboration Pervasive Computing: Middleware and Software Platforms Distributed Resource Managers, Clusters and Grids Global Grid Middleware Conclusions for the Future Emerging Technology Strategies - The book does not hype these technologies or their benefits. Section 1 of the book describes examples of past emerging technologies that failed to realize their initial vision. Based on the lessons learned from these experiences, a pragmatic technology evaluation template is created that includes: Overview of the technology Relationships to other technologies Important technical and business trends Specific applications Industry and official standards Vendor overview by application area Leading implementation approaches Advice on deployment Future technical and business directions Recommendations Audience - The information collected in this book is not available from any other single source. The broad range of technologies, standards and vendors covered is necessary to understand the future enterprise applications of the Internet. The following groups should find the contents of this book especially valuable. Decision makers for the evaluation strategy and discussions of current products, standards and open issues Developers and architects for the overview of many advanced software technologies and their relationships Consultants for the industry analysis of vendors and business applications Futurists for the trends and research that are the basis of the next generation Internet Students for the industrial applications and open source projects

Emerging Technology Strategies

Great Global Grid

David W. Dempster

Jane A. Cauley

Marjorie Luckey

Now in its fourth edition, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic fractures in the United States reach up to $18 billion each year. Worldwide, 200 million women ages 60 to 80 suffer from osteoporosis and have a lifetime risk of fracture between 30% and 40%, continuing to make osteoporosis a critical challenge in medicine. Recognizes the critical importance of the Wnt signaling pathway for bone health Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone Examines essential updates on estrogen prevention and treatment and the recent results from the WHO Discusses the controversial topics of screening and clinical trial design for drug registration Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics

Robert Marcus

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