S. R. Pandi-Perumal

Ahmed BaHammam

Haitham Jahrami

This book examines the correlation of the coronavirus disease-19 [CE1] [AAS2] (COVID-19) infection with sleep, circadian rhythm, and sleep disorders. The chapters of the book explore sleep problems during the COVID-19 pandemic and its association with psychological distress and also review the prevalence of clinical cases of insomnia, anxiety, and depression in COVID-19 patients. The book further presents the correlation between sleep, circadian rhythms, and immunity that contributes toward more severe COVID-19. It summarizes the evidence on the interplay between circadian biology, sleep, and COVID-19. The chapters of the book discuss the relationship between obstructive sleep apnea (OSA) and adverse COVID-19 outcomes. Towards the end, the book presents studies on the anti-inflammatory, antioxidant, and immunotropic properties of melatonin and provides mechanistic insights into the potential therapeutic use of melatonin during the SARS-CoV-2 infection. The last chapter describes the publication output of sleep-related research during the pandemic and provides an overview and trends on sleep and covid-19 publication output. This book is an excellent source for neurologists, sleep specialists, and public health specialists.

COVID-19 and Sleep: A Global Outlook

David L. Streiner

Joris C. Verster

Many patients experience sleep disturbances secondary to their primary illness and this often has a negative effect on their quality of life. This book provides an evidence-based introduction to the interface between sleep wide range of medical disorders. A clinically focused, comprehensive review for physicians and other health providers, this state-of-the-art reference can also serve as a textbook for those who wish to become familiar with the impact of sleep on quality of life.

Sleep and Quality of Life in Clinical Medicine

Daniel P. Cardinali

S. R Pandi-Perumal

Georgios Chrousos

This timely work reflects the growing importance of research into the nature of sleep and its medical aspects. One of the first of its kind, this work on the neuroimmunology of sleep provides an introduction to the interplay between these two key and interlinked areas. Written both from a basic and a clinical perspective, the volume is an invaluable information resource for biomedical professionals and students of the human biology. Highly practical guide written from both a basic and clinical perspective.

Neuroimmunology of Sleep

Jaime M. Monti

Eric Murillo-Rodriguez

This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol (Δ9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.

Cannabinoids and Neuropsychiatric Disorders

Michael J. Thorpy

Meeta Goswami

Narcolepsy serves as a prototype of how the interaction of high quality clinical research and groundbreaking basic science can collaborate to defne the cause of a disease and change forever how we evaluate and treat it. There is scarcely a topic in this book that would have been covered in the same way 10 years ago as it is d- cussed today. We are also fortunate that many of the players in this dramatic tu- around have contributed to this volume, so that the result is a tapestry of the events that have transformed the feld over the last decade that is both authentic and detailed. The frst section of the book provides much of the basic science background. As described in the frst two chapters, the dramatic convergence of lines of evidence from two different laboratories frst demonstrated in 1999 that narcolepsy is a disease of loss of neurotransmission by lateral hypothalamic neurons making the peptides that have been called orexins or hypocretins. These fndings did much to clarify and unify a feld that had puzzled for decades over the fundamental nature of this puzzling disease, as refected in the chapters that review its epidemiology and neuroanatomical and imaging fndings.

A Clinical Guide

Narcolepsy

Timo Partonen

Seasonal affective disorder is a mood disorder related to the change in the seasons and lack of exposure to daylight. This text presents a review of our understanding of the disorder focusing on clinical aspects as well as research issues.

Practice and Research

Seasonal Affective Disorder

James F. Pagel

Primary Care Sleep Medicine – A Practical Guide was among the first books to address sleep medicine for a primary care audience. It remains the primary text oriented to the primary care physician with an interest in sleep disorders medicine. Since this title published, there have been many changes in the sleep field. A new text oriented towards supporting the primary care physician in the practice of sleep medicine is needed; an updated second edition of Primary Care Sleep Medicine – A Practical Guide could fill this knowledge gap. This second edition will include updated information on insomnia medications, post-traumatic stress disorders, home sleep testing protocols, complex sleep apnea and the defined role for primary care physicians in sleep medicine.

A Practical Guide

Primary Care Sleep Medicine

Malcolm Lader

Many recent discoveries in both laboratory and clinical settings have greatly increased our understanding of sleep medicine and the relevant psychopharmacology. This timely book serves to present updated information about the neuropsychopharmacology of sleep as this field enters mainstream psychiatry, neurology and medicine This volume has assembled articles that summarize and review carefully, a chosen selection of the latest discoveries concerning sleep medicine, sleep physiology and sleep pharmacology. Outstanding contributions have been sought from acknowledged experts in their respective fields. The goal of the volume is to present the more recent developments and advances in the fields of sleep and neuropsychopharmacology, as well as to provide a context for considering them both in depth and from multidisciplinary perspectives. This volume brings together the collective expertise of clinicians and basic researchers who represent a range of interests in neuroscience, neuropharmacology, sleep physiology, and biological rhythms. Presenting a thoughtful balance of basic experimental and clinical facts and viewpoints, this book will serve as a foundation for understanding, and ultimately treating, sleep disorders.

A Neuropsychopharmacological Approach

Sleep and Sleep Disorders:

S. Chokroverty

This book offers a comprehensive but highly readable compilation of papers on the role of dopamine in sleep and sleep disorders. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from established theories to the latest research advances. Accordingly, it represents an interdisciplinary, cutting-edge guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, pulmonologists, psychologists, and behavioral sleep medicine specialists.

Molecular, Functional, and Clinical Aspects

Dopamine and Sleep

David N. Neubauer

Ravi Gupta (MD)

This book explores the intricate links between sleep and neuropsychiatric diseases. In clinical settings, understanding the development, treatment, and management of neuropsychiatric diseases poses a substantial challenge. Neuropsychiatric disorders place a significant cost on society, affecting the health of people affected, care providers, and the general community. Sleep and neuropsychiatric disease are inextricably linked. Sleep disorders are widespread in these populations and are frequently overlooked in neurology and psychiatry. The book offers readers up-to-date information on different facets of the bidirectional connections between sleep and neuropsychiatric diseases. Following the initial fundamental science part, a unique series of chapters concentrate on the behavioural manifestations of sleep problems, a hitherto unexplored field. Additional chapters include patient evaluation techniques as well as public health implications of sleep disorders. The individual chapters cover all main mental and neurological diseases where a change in sleep is evident, and recent concepts in pathogenesis, presentation, evaluation, and treatment. Neuropsychotropic drugs must be seen as a double-edged sword when it comes to sleep and sleep disorders. Overall, this book is an excellent resource for learning about neuropsychiatric diseases and how they affect sleep while simultaneously being impacted by sleep.

Sleep and Neuropsychiatric Disorders

Milton Kramer

This comprehensive volume provides clinicians with a better understanding of the correlation between sleep and mental illness.

Sleep and Mental Illness

Pablo Torterolo

This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.

Molecular, Functional and Clinical Aspects

Melanin-Concentrating Hormone and Sleep

As the title suggests, and unlike other existing books on sleep medicine, Neuroendocrine Correlates of Sleep/Wakefulness will be devoted primarily to endocrine regulation of the behavioral state control. It will address a wide spectrum of sleep./wakefulness phenomena (both animals and humans), including pathogenesis, diagnosis, and management. From molecular biology to applied clinical therapy, sleep research has been transformed in the last few years from a research backwater to an important interdisciplinary field. Anyone who regularly reads the literature on sleep, biological rhythms, or neuroendocrinology is aware that one of the subspecialties within sleep medicine, the neuroendocrine correlates of sleep/wakefulness, has in particular experienced a growth rate that is even faster than that of the field as a whole. To a significant extent this has been due to the introduction of new research technologies. The widespread adoption of a range of new methods in sleep research has opened a window into activities at the cellular and molecular level, which previously had been tightly closed. Consequently these activities are being characterized with a degree of precision and sensitivity that is without precedent. This volume invites the reader to explore the new vistas that have been opened onto the neuroendocrine frontier of sleep medicine. The editors have selectively identified a number of key articles having a citation frequency, which is considerably above the norm or which otherwise have contributed importantly to defining the neuroendocrine perspective. This new volume on Neuroendocrine Correlates of Sleep/Wakefulness is an up-to-date resource of research summaries and reviews written by major contributors to the fields of sleep, biological rhythms and neuroendocrinology. Its coverage is broad and its basic and clinical science reviews are detailed. In this volume, an international team of experts discuss their latest ideas, concepts, methods, and interpretations with supporting examples. This volume is intended for advanced students and specialists in psychobiology, neuroscience, neuroendocrinology, and psychiatry but might also be interest to anyone concerned with understanding the Neuroendocrine correlates of sleep/wakefulness. The contributions are directed more towards providing an integrated view of the field from the perspective of the authors, rather than being a compendium of recent results. The intent is to provide a reference book for recent and future workers in this and related areas of medicine and biology. Each topic in this volume has received the attention of a panel of authors who have responded to our request to review and place into perspective the major issues, which will undoubtedly confront newcomers to the field. The topics dealt with in Neuroendocrine correlates of Sleep/wakefulness are both diverse and complex. The editors hope that this volume will provide an authoritative summary of important issues in the neuroendocrine correlates of sleep/wakefulness. We also hope that it will motivate new researchers to join the quest for solutions to the problems that have been identified by our contributing authors.

Neuroendocrine Correlates of Sleep/Wakefulness

David J. Nutt

Barry L. Jacobs

This book focuses on the neuropsychopharmacology of serotonin and its role in sleep and wakefulness, presenting neurochemical, electrophysiological, and neuropharmacological approaches to understand the mechanisms of serotonin and related substances. Covering core and contemporary topics in the area, this volume is valuable for all researchers interested in interdisciplinary studies concerning drugs affecting the central nervous system.

Serotonin and Sleep: Molecular, Functional and Clinical Aspects

Andrew A. Monjan

Sleep disorders cause considerable morbidity and distress in the aging population. By highlighting the clinical diagnosis and management of sleep disorders, this volume provides a valuable resource for all those involved in health care of older individuals. The changes in sleep patterns that occur during normal aging are described, followed by authoritative chapters on the presentation of various age-related sleep disorders. The book deals with the range of therapeutic measures available for managing these disorders and gives insight to potential areas of research that have emerged in the last few years, such as the study of circadian rhythms in later life, sleep patterns associated with co-morbidities and the use of quality-of-life measurement tools to determine sleep quality as we age. This volume is relevant to sleep disorders specialists, psychiatrists, geriatricians and gerontologists, and any professionals and researchers working in the interdisciplinary areas of sleep and aging.

Principles and Practice of Geriatric Sleep Medicine

This is a concise and comprehensive review of geriatric sleep medicine from a multidisciplinary viewpoint.

The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.

S. R. Pandi-Perumal

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