Scott L. Rauch

Darin D. Dougherty

The past decade has witnessed tremendous progress in psychiatric neuroimaging research. Investigators have developed, in tandem with significant advances in imaging technology, innovative strategies for exploiting the awesome potential of these new tools. This volume brings you up to date on the latest developments by providing insight into the methodology of experimental design of the numerous neuroimaging articles being published in today's peer-reviewed journals. Revealing the remarkable wealth of neuroimaging's potential contributions to psychiatry, 49 distinguished contributors use accounts of their own research to illustrate the power of particular paradigmatic techniques. These techniques hold promise not only for delineating pathophysiology and advancing neuroscience, but also for yielding discoveries of direct clinical significance, such as diagnostic testing, predictors of treatment response, and new medications. Focused specifically on applications in psychiatry, these chapters are uniquely organized around experimental paradigms rather than psychiatric disorders: Using magnetic resonance imaging (MRI) to detect and characterize subtle, easily overlooked abnormalities in schizophrenia and schizotypal personality disorder. Testing specific hypotheses regarding the functional integrity of implicated neural systems within the brain as part of cognitive activation studies of schizophrenia and obsessive-compulsive disorder (OCD). Assessing the roles of the amygdala and striatum in anxiety disorders, including masked stimuli and other task manipulation methods to assay nonconscious brain activity. Investigating the neural correlates of psychiatric symptoms in anxiety disorders, using script-driven imagery and in vivo exposure to experimentally manipulate study conditions. Capturing the often elusive symptoms of hallucinations and psychomotor tics using innovative imaging techniques. Using transcranial magnetic stimulation (TMS) to investigate how the brain regulates mood. Other fascinating topics include using positron emission tomography (PET) and single photon emission computed tomography (SPECT) to discern the therapeutic mechanisms of psychotropic medications and enhance the development of new medications; integrating structural and functional imaging to treat major depression; using magnetic resonance spectroscopy (MRS) to quantify brain concentrations of exogenous compounds; using MRI to visualize circuits implicated in developmental disorders such as attention-deficit/hyperactivity disorder (ADHD) and anxiety, including ground-breaking studies of children; using functional MRI in animals and its applications in psychiatric research; and exploring the use of neuroimaging methods to investigate genetic contributions to normal cognitive function. Specialists and general clinicians alike will find much of interest in this definitive look at the exciting developments in neuroimaging today and how they can enhance our understanding and treatment of psychiatric disorders. This comprehensive text with its extensive illustrations and annotations will also prove a welcome addition to any course in the neurosciences.

Contemporary Strategies

Psychiatric Neuroimaging Research

David H. Zald

The Orbitofronal cortex plays a critical role in emotion, smell, and personality. This is the definitive volume on a brain region hitherto neglected in the neuroscience literature. It brings together world leaders in neuroscience to provide a comprehensive, integrative account of this region - one that will be the standard source for years to come.

The Orbitofrontal Cortex

Theodore A. Stern

Maurizio Fava

Jerrold F. Rosenbaum

Joseph Biederman

The Massachusetts General Hospital is widely respected as one of the world's premier psychiatric institutions. Now, preeminent authorities from MGH present a reference that is carefully designed to simplify your access to the current clinical knowledge you need! A remarkably user-friendly organization - with abundant boxed summaries, bullet points, case histories, and algorithms - speeds you to the answers you need. In short, this brand-new reference delivers all the authoritative answers you need to overcome any clinical challenge, in a format that's easier to consult than any other source! Peerless, hands-on advice from members of the esteemed MGH Department of Psychiatry helps you put today's best approaches to work for your patients. The book's highly templated format - with abundant boxed overviews, bulleted points, case histories, algorithms, references, and suggested readings - enables you to locate essential information quickly.

Massachusetts General Hospital Comprehensive Clinical Psychiatry

The use of neuroimaging studies in psychiatry is exploding -- and offers tremendous potential for practicing clinicians. Yet if you're like many psychiatrists, you're sometimes uncertain about which studies to use in specific situations. Until now, you've had to sort through the only information available -- technical reviews in the literature -- for guidance. But no more. Essentials of Neuroimaging for Clinical Practice is an all-in-one resource that explains how to use these powerful techniques to improve outcomes. It demystifies neuroimaging with clear, concise, and practical advice on using today's most advanced applications in the diagnostic workup of patients. This practical clinical guide will help you achieve a solid understanding of the full range of neuroimaging modalities: Structural techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) Functional techniques such as positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), and magnetic resonance spectroscopy (MRS) Other techniques such as electroencephalography (EEG) -- including quantitative EEG and event-related potentials -- and magnetoencephalography. For each modality, you'll find: A basic review of the technique -- trace the development of each modality, and become familiar with its underlying technology. Guidance on when to use it -- learn which techniques are best to use in specific clinical situations. Tips for ordering studies -- discover how to write up orders to obtain the most accurate and detailed information from each study, including when to use contrast and how to determine the best acquisition parameters. A look at its future potential in practice and research -- explore the current capabilities of each modality and the most promising strategies for improving diagnostic results. Filled with examples of real-life imaging studies, Essentials of Neuroimaging for Clinical Practice is a must-have tool for all practicing psychiatrists and psychologists. In addition, it will serve as an excellent clinical guide for residents -- and an outstanding text for courses in clinical neuroimaging for psychiatrists.

Essentials of Neuroimaging for Clinical Practice

Benjamin D. Greenberg

Joan A. Camprodon

This volume covers the gamut of surgical and device-based treatments for psychiatric disorders. Written by experts in the field, this book covers neuroscience advances in the neurobiological underpinnings of psychiatric diseases, emerging surgical and device-based treatments, and advances in the field. Topics include electroconvulsive therapy, transcranial magnetic stimulation, Vagus nerve stimulation (VNS), and many other cutting-edge treatments and techniques. Psychiatric Neurotherapeutics is a valuable resource for psychiatrists, neurosurgeons, neurologists, researchers, and all other medical professionals interested in surgical and device-based treatments of psychiatric disorders.

Scott L. Rauch

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