Stanley G. Schultz

Thomas E. Andreoli

Joseph F. Hoffman

Michael J. Welsh

A.M. Brown

D.M. Fambrough

When the six of us gathered to start planning for what was to be the Third Edition of Physiology of Membrane Disorders, it was clear that since 1986, when the Second Edition appeared, the field had experienced the dawning of a new era dominated by a change in focus from phenomenology to underlying mechanisms propelled by the power of molecular biology. In 1985, detailed molecular information was available for only three membrane transporters: the lac permease, bacterial rhodopsin, and the acetylcholine receptor. During the decade that has since elapsed, almost all of the major ion channels and transport proteins have been cloned, sequenced, mutagenized, and expressed in homologous as well as heterologous cells. Few, if any, of the transporters that were identified during the previous era have escaped the probings of the new molecular technologies and, in many instances, considerable insight has been gained into their mechanisms of function in health and disease. Indeed, in some instances novel, unexpected transporters have emerged that have yet to have their functions identified. The decision to adopt the new title Molecular Biology of Membrane Transport Disorders was a natural outgrowth of these considerations.

Molecular Biology of Membrane Transport Disorders

Darrell D. Fanestil

Membrane Physiology (Second Edition) is a soft-cover book containing portions of Physiology of Membrane Disorders (Second Edition). The parent volume contains six major sections. This text encompasses the first three sections: The Nature of Biological Membranes, Methods for Studying Membranes, and General Problems in Membrane Biology. We hope that this smaller volume will be helpful to individuals interested in general physiology and the methods for studying general physiology. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL STANLEY G. SCHULTZ vii Preface to the Second Edition The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition. Yet the purpose of the second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably.

Membrane Physiology

Brenda B. Rauner

Gabriel M. Makhlouf

This volume marks the coming of age of knowledge concerning the neural and endocrine biology of the gut. It is the first volume in the Handbook of Physiology to be devoted entirely to this field. It is also the very first volume ever published that deals systematically with the biochemistry, cell biology, molecular biology, pharmacology, and physiology of hormonal and neural peptides of the gut. Written by some forty recognized experts, Neural and Endocrine Biology details the discoveries of a field that is now just twenty-five years old. The early chapters address general topics and provide a broad overview of the field, including information on immunocytochemistry of endocrine cells and enteric neurons and the physiological significance of hormonal, paracrine, and neural peptides. Fourteen of the volume's twenty-eight chapters are devoted to individual hormonal and neural peptides--their distribution, pharmacology, and physiological and cellular functions. The final chapter offers an overview of recently discovered peptides, including pancreastatin and two neural peptides, galanin and calcitonin gene-related peptide (CGRP). Neural and Endocrine Biology will be a welcome new resource for graduate students, instructors, and active researchers and clinicians who need a complete, up-to-date reference in regulatory peptides and gastrointestinal physiology and pharmacology.

Neural and Endocrine Biology

The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition . Yet the purpose ofthe second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably. THE EDITORS xi Preface to the First Edition The purpose of this book is to provide the reader with a rational frame of reference for assessing the pa thophysiology of those disorders in which derangements of membrane transport processes are a major factor responsible for the clinical manifestations of disease. In the present context, we use the term "membrane transport to refer to those molecular processes whose cardinal function, broadly speaking, is processes" in a catholic sense, the vectorial transfer of molecules-either individually or as ensembles-across biological interfaces, the latter including those interfaces which separate different intracellular compartments, the cellular and extracellular com partments, and secreted fluids-such as glomerular filtrate-and extracellular fluids.

Physiology of Membrane Disorders

Michael Field

Raymond A. Frizzell

American Physiological Society (1887- )

Here is a thorough, up-to-date survey of the physiological processes through which salt, water, and nutrients are absorbed or secreted by the intestinal tract, and of how these myriad processes are regulated. In twenty-five chapters, written by a team of leading experts, the volume addresses four main topics: the methodologies and basic principles of structure and function; intestinal ion transport; nutrient absorption; and macromolecular transport. Throughout, the contributors emphasize recent developments in the field--for example, neuroendocrine-immune cell interactions in the intestinal mucosa, the regulation of intestinal sodium transport, the cloning of the intestinal glucose carrier, the intestinal cytoskeleton, and the regulation of intestinal epithelial transport function by protein kinases and calmodulin. This is not only the fourth and final volume in the series; it is also the broadest, most contemporary approach to this important topic. As such, this book will be warmly welcomed--and often consulted--by student, scholars, professionals, and anyone researching intestinal absorptive mechanisms and their regulation.

Stanley G. Schultz

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