Stefan Jordan

Javier Leceta

Rosa Del Campo

Christoph Siegfried Niki Klose

Immunoregulation at Mucosal Surfaces

Markus G. Manz

Henrik Paul Einwächter

Alexander Frank Heiseke

Andreas Bernhard Schlitzer

Georg Gasteiger

Heiko Adler

David Vöhringer

Zsolt Ruzsics

Lars Dölken

Ulrich H. Koszinowski

Tim Dominik Sparwasser

Wolfgang Reindl

Abstract: Dendritic cells (DC) play a key role in the adaptive immune response due to their ability to present antigens and stimulate naïve T cells. Many bacteria and viruses can efficiently target DC, resulting in impairment of their immunostimulatory function or elimination. Hence, the DC compartment requires replenishment following infection to ensure continued operational readiness of the adaptive immune system. Here, we investigated the molecular and cellular mechanisms of inflammation-induced DC generation. We found that infection with viral and bacterial pathogens as well as Toll-like receptor 9 (TLR9) ligation with CpG-oligodeoxynucleotide (CpG-ODN) expanded an erythropoietin (EPO)-dependent TER119+CD11a+ cell population in the spleen that had the capacity to differentiate into TER119+CD11chigh and TER119−CD11chigh cells both in vitro and in vivo. TER119+CD11chigh cells contributed to the conventional DC pool in the spleen and specifically increased in lymph nodes draining the site of local inflammation. Our results reveal a so far undescribed inflammatory EPO-dependent pathway of DC differentiation and establish a mechanistic link between innate immune recognition of potential immunosuppressive pathogens and the maintenance of the DC pool during and after infection

The Innate Immune Response to Infection Induces Erythropoietin-dependent Replenishment of the Dendritic Cell Compartment

Robert Fischer

Christiane Gsänger

"Paris is still this monstrous miracle, this collection of movements, machines and thoughts that arouse nothing but amazement, the city of a hundred thousand novels, the head of the world." Balzac's observation is as valid today as it was then. The city has been praised in song, provided atmospheric backdrop for countless films and novels, served as the center for the French chanson style, and is for many stil( the "City of Love". Indeed, it is often love at first sight, sitting over a café crème or a pastis in a street café in the lively Quartier Latin, admiring the panorama from Sacré-Coeur, enjoying a romantic cruise along the Seine, taking a relaxing stroll in the Jardin du Luxembourg, or just standing in front of one of the important works of art in a museum - virtually no one can resist the charm of this metropolis. THE PARIS BOOK invites you to embark on a fascinating journey through this glorious city and reveals its endless variety in brilliant color photos and informative texts. Foldout panorama photos provide spectacular views of the metropolis, which, as a center of culture, intellectualism and savoir-vivre, has long attracted artists, scholars, adventurers and anyone with a thirst for life. Page after page you will be shown a new perspective on thé highlights of the city Hemingway described as "a moveable feast".

Highlights of a Fascinating City

The Paris Book

Diese studienpraktische Einführung erleichtert den Einstieg ins Geschichtsstudium. Sie verschafft Überblick über die Universität als Arbeitsplatz und Lebensraum, die Gliederung und Anforderungen des Fachs Geschichtswissenschaft, die grundlegenden Arbeitstechniken und Methodiken, die Arbeits- und Hilfsmittel. Wer sich damit gründlich vertraut macht, kommt schneller und sicher zum Eigentlichen: zur Geschichte und zur Geschichtsschreibung. E-Book mit Seitenzählung der gedruckten Ausgabe: Buch und E-Book können parallel benutzt werden.

Reclams Universal-Bibliothek

Einführung in das Geschichtsstudium

Sina Farzin

Hundert Grundbegriffe

Lexikon Soziologie und Sozialtheorie

Gunna Wendt

Wie wirkt sich die körperliche und seelische Grundausstattung eines Menschen auf sein Fühlen, Denken, Erleben und Handeln aus? Die Fragestellungen der Psychologie bewegen jeden. Das 'Lexikon Psychologie' liefert hundert Artikel zu den zentralen Bereichen der Psychologie, zu den wichtigsten Grundbegriffen, Krankheitsformen und aktuellen Themen. Was also genau ist gemeint, wenn von 'Angst', 'Emotion', 'Trauma' oder 'Zwang' gesprochen wird? Fachvertreter geben in einlässlichen, speziell für diesen Band verfassten Beiträgen Antwort.

hundert Grundbegriffe

Lexikon Psychologie

Stefan Jordan

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