David Thorne

Teresa K. Attwood

Stephen R. Pettifer

This innovative book provides a completely fresh exploration of bioinformatics, investigating its complex interrelationship with biology and computer science. It approaches bioinformatics from a unique perspective, highlighting interdisciplinary gaps that often trap the unwary. The book considers how the need for biological databases drove the evolution of bioinformatics; it reviews bioinformatics basics (including database formats, data-types and current analysis methods), and examines key topics in computer science (including data-structures, identifiers and algorithms), reflecting on their use and abuse in bioinformatics. Bringing these disciplines together, this book is an essential read for those who wish to better understand the challenges for bioinformatics at the interface of biology and computer science, and how to bridge the gaps. It will be an invaluable resource for advanced undergraduate and postgraduate students, and for lecturers, researchers and professionals with an interest in this fascinating, fast-moving discipline and the knotty problems that surround it.

Mind the Gap

Bioinformatics Challenges at the Interface of Biology and Computer Science

David J. Parry-Smith

Bioinformatics, the application of computers in biological sciences and especially analysis of biological sequence data, is becoming an essential tool in molecular biology as genome projects generate vast quantities of data. This text provides an introduction to the subject for undergraduates (final year), focussing on two key areas, genojmics and protein sequence analysis. It provides an overview of primary, composite and secondary databases, and gives a brief introduction to the Internet and the World Wide Web.

Introduction to Bioinformatics

Paul G. Higgs

In the current era of complete genome sequencing, Bioinformatics and Molecular Evolution provides an up-to-date and comprehensive introduction to bioinformatics in the context of evolutionary biology. This accessible text: provides a thorough examination of sequence analysis, biological databases, pattern recognition, and applications to genomics, microarrays, and proteomics emphasizes the theoretical and statistical methods used in bioinformatics programs in a way that is accessible to biological science students places bioinformatics in the context of evolutionary biology, including population genetics, molecular evolution, molecular phylogenetics, and their applications features end-of-chapter problems and self-tests to help students synthesize the materials and apply their understanding is accompanied by a dedicated website - www.blackwellpublishing.com/higgs - containing downloadable sequences, links to web resources, answers to self-test questions, and all artwork in downloadable format (artwork also available to instructors on CD-ROM). This important textbook will equip readers with a thorough understanding of the quantitative methods used in the analysis of molecular evolution, and will be essential reading for advanced undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics courses.

Teresa K. Attwood

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