Wen T. Shen

Sanziana A. Roman

Julie Ann Sosa

This book provides a practical, evidence-based approach to controversies in the management of thyroid nodules and differentiated thyroid cancer (DTC). Thyroid nodules are a commonly encountered clinical entity, identified in 2-6% of the population by palpation, and 20-35% by ultrasound. DTC is the solid organ cancer with the most rapidly increasing incidence (>50,000 new cases in the U.S. annually). Despite extensive research and multiple published comprehensive practice guidelines, numerous controversies remain within this field covering a wide range of issues, including incidence and epidemiology, radiographic evaluation, criteria for needle biopsy, cytopathologic and molecular diagnostics, active surveillance vs. operation for low-risk tumors, extent of surgery, indications for radioactive iodine treatment and external beam radiation, and optimal protocols for follow-up. The book takes a case-based approach: each chapter will begin with a patient presentation highlighting a particular controversial subject in thyroid nodules and DTC. The remainder of the chapter discusses the controversy within the context of current scientific understanding and clinical practice, using the latest evidence-based practice guidelines. Chapters conclude with a final review and discussion of the opening case, with options and recommendations for next steps provided. The recommendations are evidence-based and practical, intended to help guide practitioners in their ongoing care of patients with thyroid nodules and DTC. Each chapter was written by a recognized expert in the area of controversy, including endocrine surgeons, endocrinologists, radiologists, medical oncologists, and nuclear medicine specialists. Controversies in Thyroid Nodules and Differentiated Thyroid Cancer: A Case-Based Approach is an excellent guide for oncologists, endocrinologists, otorhinolaryngologists, surgeons, and practitioners of all types that care for patients with thyroid nodules and DTC.

A Case-Based Approach

Controversies in Thyroid Nodules and Differentiated Thyroid Cancer

Martha A. Zeiger

Erin A. Felger

Endocrine surgery - the subspecialty of general surgery involving diseases of the thyroid, parathyroid, and adrenal glands as well as the endocrine pancreas - is a rapidly growing field of medicine that has a rich and fascinating history. As recently as the mid-19th Century, surgery for thyroid goiter was described as "horrid butchery" and believed by many to be too dangerous for any surgeon to attempt. Through the ingenuity and tireless efforts of surgeons in Europe and the U.S., thyroidectomy became a safe and even elegant operation, one that renowned Johns Hopkins surgeon William Halsted would describe in 1926 as representing "the supreme triumph of the surgeon's art." In this unique and captivating book, these and other seminal stories from the history of endocrine surgery are vividly retold by the current leaders in the field.

Wen T. Shen

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