Yashwant V. Pathak

Karam F.A. Soliman

The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas. Key Features: Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals Presents flavonoid-based functional foods Discusses the flavonoid nutraceuticals market and future trends Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2

Flavonoids and Anti-Aging

Jayvadan K. Patel

Govindan Parayil

Sustainable Nanotechnology A robust examination of the use of nanotechnology in the manufacture of sustainable products In Sustainable Nanotechnology: Strategies, Products, and Applications, a team of distinguished researchers delivers a comprehensive and up-to-date exploration of nanotechnology applications in environmental, pharmaceutical, and engineering products in the context of global sustainability. The book offers balanced coverage of the benefits and risks of nanotechnology. Divided into three parts, the editors have included contributions from leading scholars discussing sustainability, toxicological impacts, and nanomaterial-based adsorbents. This edited volume helps readers understand how nanotechnology and nanomaterials apply in different global sustainability challenges. It also discusses models for understanding the lifecycle and risk assessments of manufactured nanomaterials. Case studies are included to explore such topics as design, remediation, and technology assessment. The book also provides: Thorough introductions to nanotechnology-based research priorities for global sustainability and the challenges and opportunities of modern, sustainable nanotechnology Comprehensive explorations of improving the sustainability of bio-based products with nanotechnology and the improvement of the environmental sustainability of biopolymers using nanotechnology Practical discussions of nanotechnology-based polymers for drug delivery applications In-depth examinations of green nanotechnology-driven drug delivery systems Perfect for nanotechnology-focused professionals, sustainability experts, biomedical experts, and pharmaceutical industry practitioners, Sustainable Nanotechnology: Strategies, Products, and Applications will also earn a place in the libraries of neuroscientists, bioengineering professionals, and those involved in neuroprosthetic engineering.

Strategies, Products, and Applications

Sustainable Nanotechnology

Malay K. Das

This book reviews the application of Nanobiotechnology in the development of Nanomedicine, while also discussing the latest trends and challenges in the clinical translation of Nanomedicine. Nanomedicine refers to the application of Nanotechnology to medicine and holds tremendous potential for achieving improved efficiency, bioavailability, dose response, personalized medicine and enhanced safety as compared to conventional medicines. The book first introduces readers to the basic concepts of Nanomedicine, and to technological advances in and applications of Nanotechnology in treatment, diagnosis, monitoring, and drug delivery. In turn, it reviews the current status of multi-functionalization strategies for using Nanoparticles in the targeted delivery of therapeutic agents. The book’s third and final section focuses on the regulatory and safety challenges posed by Nanomedicine, including industry and regulatory agencies’ efforts to address them.

Recent Trends and Clinical Evidences

Nano Medicine and Nano Safety

This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges. .

Emerging Technologies for Nanoparticle Manufacturing

Somdat Mahabir

Although health claims for nutraceuticals range from the fantastic to the sublime, most of these claims are based on cell culture studies and have not been validated in humans, making them inadequate for public health recommendations. Focusing on human population-based research (epidemiology studies), Nutraceuticals and Health: Review of Human Evidence explores the role of nutraceuticals in human health, disease prevention, health promotion, and as an adjunct to disease treatment. The editors and their team of recognized experts deliver a comprehensive scientific review of the latest research. The book opens with a general background of nutraceuticals and human health, then covers health and disease areas such as cancer, lipidermia and cardiovascular disease, metabolic syndrome with obesity, diabetes and hypertension, respiratory health, the gut microbiome, and cognitive decline. It then concludes by addressing the methodological issues that must be addressed in the conduct of epidemiological research on nutraceuticals in health and disease. Although nutraceuticals hold significant promise in alleviating the suffering from disease, for this potential to be fulfilled, much more research is needed to document safety and disease risks in humans. Addressing important knowledge gaps, the book includes cutting-edge summaries that highlight both the biological and epidemiological findings of relevant studies of nutraceuticals in health and disease. Taking an unusual, yet crucial epidemiological focus, it examines whether, and what kinds of, evidence exist to support a role for nutraceuticals in disease risk, prevention, and treatment.

Yashwant V. Pathak

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