Muscarinic Agonists and the Treatment of Alzheimer's Disease

Details recent advances in basic, applied, and clinical sciences relevant to the etiology and treatment of Alzheimer's disease, focusing on m1 agonists. Reviews findings in the involvement of the cholinergic systems in Alzheimer's; the rationale for designing m1 agonists; and the involvement of m1 receptors in amyloid precursor proteins, neurotrophic activities, and the effects on phosphorylation of tau protein. Emphasis is on the structure-activity relationship of the interaction of agonists with muscarine receptor subtypes and m1 receptors. For researchers in molecular biology and medicine. Annotation copyright by Book News, Inc., Portland, OR