Benjamin Lewin

Editor of Cell Benjamin Lewin

Lewin

Genes VII gives an integrated and authoritative account of the structure and function of genes. It is thoroughly up to date with the latest research and thinking in the field. Successive editions have provided an integrated account of the whole field of modern molecular genetics and thisedition continues that approach, providing a new synthesis and continuing the greater emphasis on how genes function in their biological context. In a change to all previous editions, which started with a traditional analysis of formal genetics, this seventh edition has been organised to present thesubject in the context of the eukaryotic gene as revealed in the last decade, an analysis based directly on the molecular properties of the gene itself.From the Preface: "The thesis of Genes is that only by understanding the structure and function of the gene itself will we be able in turn to understand the operation of the genome as a whole. Although the emphasis has shifted to the characterization of eukaryotic genes, and therefore to theiranalysis by the direct techniques of molecular biology rather than the subtlety of genetics, the classical approach remains intellectually penetrating. It remains an aim of this book to integrate both approaches in the context of a unified approach to prokaryotes and eukaryotes."

Genes Seven

Cells obey the laws of physics and chemistry; DNA as a store of information; Genes are metable units; DNA is the genetic material; The topology of nucleic acids; Isolating the gene; Turning genes into proteins; The assembly line for protein sysnthesis; Transfer RNA: the translational adaptor; The ribosome translation factory; The messenger RNA templlate; Controlling gene expression by transcription; RNA polymerase-promoter interactions control initiation; A panoply of operons: the lactose paradigm and others; Control at termination: attenuation and antitermination; Lytic cascades and lysogenic repression; Perpetuation of DNA; The replicon: unit of replication; The apparatus for DNA replication; Systems that safeguard DNA; Constitution of the eukaryotic genome; The extraordinary power of DNA technology; A continuum of sequences includes structural genes; The organization of interrupted genes; Clusters of relates sequences; Structural genes belond to families of various sizes; Genomes sequestered in organelles; Organization of simple sequence DNA; Reachiong maturity: RNA processing; Cutting and trimming stable RNA; RNNA as catalyst: mechanisms of splicing; Control of RNA processing; The packaging of DNA; About genomes and chromosomes; Chromatin structure: the nucleosome; The nature of active chromatin; The dynamic genome: DNA in flux; Recombination and other topological manipulations of DNA; Transposable elements in bacteria; Mobile elements in eukaryotes; Enginnering changes in the genome; Genes in development; Rearrangements and the generation of immune diversity; Changing gene organization from within and without; Gene regulation: changing patterns of expression; Oncogenes: aberrant gene expression and cancer; Landmark changes in perspectives.

Editor of Cell Benjamin Lewin

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