Fritjof Capra

Pier Luigi Luisi

The first volume to integrate life's biological, cognitive, social, and ecological dimensions into a single, coherent framework.

A Unifying Vision

The Systems View of Life

From Chemical Origins to Synthetic Biology

The Emergence of Life

Ao longo dos últimos 35 anos, uma concepção radicalmente nova da vida emergiu na linha de frente da ciência contemporânea. Essa nova visão transcende a visão mecanicista e envolve uma nova espécie de pensamento: o pensamento "sistêmico". Capra e Luisi integram, nesse livro, os muitos conceitos, modelos e teorias dessa nova compreensão científica da vida em um único arcabouço coerente. Fazendo uma ampla varredura pela história e pelas disciplinas científicas, apresentam uma visão sistêmica unificada que inclui e integra as dimensões biológica, cognitiva, social e ecológica da vida, além de discutir as implicações dessa visão para as nossas crises ecológicas e econômicas globais.

Uma Concepção Unificada E Suas Implicações Filosóficas, Políticas, Sociais E Econômicas

A Visão Sistêmica da Vida

Pasquale Stano

In the last ten years there has been a considerable increase of interest on the notion of the minimal cell. With this term we usually mean a cell-like structure containing the minimal and sufficient number of components to be defined as alive, or at least capable of displaying some of the fundamental functions of a living cell. In fact, when we look at extant living cells we realize that thousands of molecules are organized spatially and functionally in order to realize what we call cellular life. This fact elicits the question whether such huge complexity is a necessary condition for life, or a simpler molecular system can also be defined as alive. Obviously, the concept of minimal cell encompasses entire families of cells, from totally synthetic cells, to semi-synthetic ones, to primitive cell models, to simple biomimetic cellular systems. Typically, in the experimental approach to the construction of minimal the main ingredient is the compartment. Lipid vesicles (liposomes) are used to host simple and complex molecular transformations, from single or multiple enzymic reactions, to polymerase chain reactions, to gene expression. Today this research is seen as part of the broader scenario of synthetic biology but it is rooted in origins of life studies, because the construction of a minimal cell might provide biophysical insights into the origins of primitive cells, and the emergence of life on earth. The volume provides an overview of physical, biochemical and functional studies on minimal cells, with emphasis to experimental approaches. 15 International experts report on their innovative contributions to the construction of minimal cells.

The Biophysics of Cell Compartment and the Origin of Cell Functionality

The Minimal Cell

Addressing the emergence of life from a systems biology perspective, this new edition has undergone extensive revision, reflecting changes in scientific understanding and evolution of thought on the question 'what is life?'. With an emphasis on the philosophical aspects of science, including the epistemic features of modern synthetic biology, and also providing an updated view of the autopoiesis/cognition theory, the book gives an exhaustive treatment of the biophysical properties of vesicles, seen as the beginning of the 'road map' to the minimal cell - a road map which will develop into the question of whether and to what extent synthetic biology will be capable of making minimal life in the laboratory. Fully illustrated, accessibly written, directly challenging the reader with provocative questions, offering suggestions for research proposals, and including dialogues with contemporary authors such as Humberto Maturana, Albert Eschenmoser and Harold Morowitz, this is an ideal resource for researchers and students across fields including bioengineering, evolutionary biology, molecular biology, chemistry and chemical engineering.

This collection of essays highlights, in a new, critical fashion, some of the classic questions in life science. These include “what is life?”; “what is death?”; “what is consciousness?”; “why is life cellular?”; and “why are enzymes macromolecules?”. It also explores whether evolution is pre-determined, whether science and spirituality can harmonize with each other, whether artificial intelligence is at odds with the human spirit, and whether, and to what extent, we are genetically determined. In this text, some of the main conceptual tools used to tackle life’s many aspects are necessarily reviewed, such as the systems view of life, the notion of contingency, and the concept of autopoiesis. Each of the three chapters of the book contains a number of short science fiction stories which discuss aspects of the present-day development of artificial intelligence.

Essays on Life Sciences, with Related Science Fiction Stories

Stefano Colonna

Gail R. Fleischaker

How did life begin on the Earth? The units of life are cells, which can be defined as bounded systems of molecules that capture energy and nutrients from the environment -- systems that expand, reproduce, and evolve over time, often into more complex systems. This book is the proceedings of a unique meeting, sponsored by NATO and held in Maratea, Italy, that brought together for the first time an international group of investigators who share an interest in how molecules self-assemble into supramolecular structures, and how those structures may have contributed to the origin of life. The book is written at a moderately technical level, appropriate for use by researchers and by students in upper-level undergraduate and graduate courses in biochemistry and molecular biology. The overall interest of its subject matter provides an excellent introduction for students who wish to understand how the foundational knowledge of chemistry and physics can be applied to one of the most fundamental questions now facing the scientific community. The editors are pioneers in defining what we mean by the living state, particularly the manner in which simple molecular systems can assume complex associations and functions, including the ability to reproduce. Each chapter of the book presents an up-to-date report of highly significant research. Two of the authors received medals from the National Academy of Science USA in 1994, and other research reported in the book has been featured in internationally recognized journals such Scientific American, Time, and Discover.

From Synthetic Structures to Models of Minimal Living Systems

Self-Production of Supramolecular Structures

Cristiano Chiarabelli

Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.

Chemical Synthetic Biology

Over the past thirty years, a new systemic conception of life has emerged at the forefront of science. New emphasis has been given to complexity, networks, and patterns of organisation leading to a novel kind of 'systemic' thinking. This volume integrates the ideas, models, and theories underlying the systems view of life into a single coherent framework. Taking a broad sweep through history and across scientific disciplines, the authors examine the appearance of key concepts such as autopoiesis, dissipative structures, social networks, and a systemic understanding of evolution. The implications of the systems view of life for health care, management, and our global ecological and economic crises are also discussed. Written primarily for undergraduates, it is also essential reading for graduate students and researchers interested in understanding the new systemic conception of life and its implications for a broad range of professions - from economics and politics to medicine, psychology and law.

This fully updated and expanded edition addresses the origins of biological and synthetic life from a systems biology perspective.

Zara Houshmand

For over a decade, a small group of scientists and philosophers& mdash;members of the Mind and Life Institute& mdash;have met regularly to explore the intersection between science and the spirit. At one of these meetings, the themes discussed were both fundamental and profound: can physics, chemistry, and biology explain the mystery of life? How do our philosophical assumptions influence science and the ethics we bring to biotechnology? And how does an ancient spiritual tradition throw new light on these questions? Pier Luigi Luisi not only reproduces this dramatic, cross-cultural dialogue, in which world-class scientists, philosophers, and Buddhist scholars develop a holistic approach to the scientific exploration of reality, but also adds scientific background to their presentations, as well as supplementary discussions with prominent participants and attendees. Interviews with His Holiness the Karmapa, the Buddhist monk Matthieu Ricard, and the actor and longtime human rights advocate Richard Gere take the proceedings into new directions, enriching the material with personal viewpoints and lively conversation about such topics as the origin of matter, the properties of cells, the nature of evolution, the ethics of genetic manipulation, and the question of consciousness and ethics. A keen study of character, Luisi incorporates his own amusing observations into this fascinating dialogue, painting a very human portrait of some of our greatest& mdash;and most intimidating& mdash;thinkers. Deeply textured and cleverly crafted, Mind and Life is an excellent opportunity for any reader to join in the debate surrounding this cutting-edge field of inquiry.

Discussions with the Dalai Lama on the Nature of Reality

Mind and Life

The origin of life from inanimate matter has been the focus of much research for decades, both experimentally and philosophically. Luisi takes the reader through the consecutive stages from prebiotic chemistry to synthetic biology, uniquely combining both approaches. This book presents a systematic course discussing the successive stages of self-organisation, emergence, self-replication, autopoiesis, synthetic compartments and construction of cellular models, in order to demonstrate the spontaneous increase in complexity from inanimate matter to the first cellular life forms. A chapter is dedicated to each of these steps, using a number of synthetic and biological examples. With end-of-chapter review questions to aid reader comprehension, this book will appeal to graduate students and academics researching the origin of life and related areas such as evolutionary biology, biochemistry, molecular biology, biophysics and natural sciences.

Pier Luigi Luisi

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