Huntington's Disease

It is now almost a decade since the identification of the Huntington's Disease gene and its mutation. Major advances in our understanding of the disorder have been made during this time. Since publication of the first two editions of this book, considerable progress has been made into understanding how the mutation causes the symptoms and brain pathology of HD. Experimental tools are in place to take this research further towards new therapeutic approaches. Due to these major advances, this well-established book has required radical updating. An international group of researchers and clinicians with specialist interests in Huntington's Disease have been commissioned to document the major recent advances in the genetics and neurobiology of the disease. Developments in our understanding of how the molecular basis of the disorder results in brain degeneration, with full coverage of transgenic animal models, neurochemical studies and advances in neuropathology are discussed in detail. The clinical sections.