The Gene
Complex
Educational

The Gene An Intimate History

Selected as a Book of the Year by The New York Times, The Economist, Independent, Observer and Mail on Sunday THE NEW YORK TIMES NUMBER ONE BESTSELLER SHORTLISTED FOR THE WELLCOME BOOK PRIZE 2017 ‘Dramatic and precise... [A] thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time... He is a natural storyteller... A page-turner... Read this book and steel yourself for what comes next’ Bryan Appleyard, Sunday Times The Gene is the story of one of the most powerful and dangerous ideas in our history, from bestselling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a ‘unit of heredity’. It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.
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Reviews

Photo of Rohit Khanduri
Rohit Khanduri@johnnydrama
4 stars
Apr 8, 2024

The Gene: An Intimate History is a comprehensive and thoroughly researched exploration of genetics and its impact on humanity. The book is lengthy, but the depth of information and engaging storytelling make it a worthwhile read. Mukherjee masterfully weaves together scientific discoveries, personal stories, and ethical dilemmas to provide a nuanced understanding of genetics. Although some sections may be dense for readers unfamiliar with biology, the author's ability to explain complex ideas in accessible language makes this book a valuable resource for anyone interested in the history and future of genetics.

Photo of Q
Q@qontfnns
5 stars
Mar 13, 2024

what a ride

Photo of Wynter
Wynter@wynter
4 stars
May 4, 2023

An exhaustive (and exhausting) book on history of genetics. I'm glad I read it, but boy oh boy, am I ever glad I am done. My brain is overloaded with amazing information that will take a long while to digest. Some people find the author's constant digressions to his own family's history distracting and unnecessary, but I really enjoyed those. It created a personal narrative among the piles of tedious scientific data. Read it if you are seriously looking into the subject, but skip it in favour of something more casual, if passing interest is your only motivation.

Photo of Bouke van der Bijl
Bouke van der Bijl@bouk
5 stars
Mar 1, 2023

Genes are fucking wild. They have a much bigger impact than I was aware of, and we know much more about them than I expected. This book thought me a lot about how life and DNA works, and is an incredible history of genetic biology. It also makes me incredibly excited/terrified of what we will be capable of in the future. Just a random example, but one of the craziest things is the existence of Eutelies, which are organisms like C. Elegans that have an exactly fixed number of cells at adulthood. An adult C. Elegans has 1031 cells when it reaches maturity, and scientists have traced the course every individual one of those cells goes through until it lands in its final position. Wild!!!

Photo of Matthew Serrano
Matthew Serrano@mserrano
4 stars
Jan 21, 2023

Great overall survey but a little repetitive.

Photo of Summer Stanley
Summer Stanley@sgs
3 stars
Apr 26, 2022

A little too long and repetitive, but I learned some very cool stuff! Loved the sections on old theories of genetics and the history of the human genome project.

+2
Photo of Ivan Vega
Ivan Vega@ivanyv
5 stars
Apr 15, 2022

I found the narrative surprisingly riveting.

Photo of Hazal Özlem
Hazal Özlem@sirunmanug
5 stars
Apr 4, 2022

** spoiler alert ** Yazarın “Tüm Hastalıkların Şahı” kitabında da olduğu gibi bu kitapta da “gen” kavramının ilk ortaya çıktığı zamanlardan kitabın yazıldığı güne kadar gelinen noktayı; gen, genetik, genom tanımlarını, ne olduğumuzu ne yapabileceğimizi anlatıyor. Nedenleri anlayabilmek için mükemmel bir rehber. Çok yol aldığımızın ama aynı zamanda tıpkı kanser konusunda olduğu gibi aldığımız yolun bir arpa boyu olmadığının ispatı. Konu hakkında bilgisi olan veya olmayan herkes için harika bir bilimsel kitap.

Photo of Omar Fernandez
Omar Fernandez@omareduardo
4 stars
Dec 10, 2021

What I love most about this book is how it took me through the history of how humans came to understand the gene, trying to answer fundamental questions around evolution, heredity and more. Once enthralled by the success of human beings in discovering the source of instructions that affect all aspects of our development as individuals and as a species, it then takes us into the new paradigm. What is the opportunity, and the danger, humans have now that we have tools that can fundamentally change the most fundamental set of instructions that guides our development.

Photo of Igor T
Igor T@igor
5 stars
Sep 13, 2021

Awesome book

Photo of Christine Liu
Christine Liu@christineliu
5 stars
Sep 1, 2021

The Gene made me feel like I took a semester long seminar on the history of genetics. This book is truly astonishing in its scope. From Mendel's experiments breeding pea plants in a monastery to mapping the full human genome and cloning, this book is a brilliant and highly readable journey through the field as well as an exploration of the difficult ethical issues we still have to contend with as our scientific and technological capabilities expand at an exponential rate. I enthusiastically recommend this book to anyone interested in learning more about what makes us us. It's an undertaking for sure, but so worth it.

Photo of Jeremy Cote
Jeremy Cote@cote
5 stars
Aug 7, 2021

What an amazing book. As a physics student, I've never been too attracted to biology, but this author writes so well that I just loved the book. I was a bit apprehensive at first, since the book is so long, but it is well worth the effort and reading the book is a breeze. The author packs in a huge amount of detail for someone like myself who knows a lot about science, but has never delved into the specifics of biology. It frankly makes me excited for the future and interested in taking more classes in genetics. Fantastic writing. Read this book. You won't regret it.

Photo of Udit Desai
Udit Desai@uydesai
3.5 stars
Dec 9, 2022
Photo of Timeo Williams
Timeo Williams@timeowilliams
4 stars
Jun 5, 2024
Photo of Richu A Kuttikattu
Richu A Kuttikattu@richuak
4 stars
Mar 26, 2024
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Brendan M@bmaclean05
4 stars
Feb 19, 2024
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adcv@adcv
5 stars
Feb 2, 2024
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Olivia@owalsh2
5 stars
Jan 4, 2024
Photo of D VA
D VA@pneumatic
3 stars
Dec 25, 2023
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Jayme Cochrane@jamesco
5 stars
Dec 20, 2023
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Geetika @geetening
5 stars
Dec 18, 2023
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Heiki Riesenkampf@hrk
4 stars
Dec 18, 2023
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Beth Seaton@bethseaton
5 stars
Nov 7, 2023
Photo of Jeffrey Jose
Jeffrey Jose@jeffjose
5 stars
Oct 17, 2023